Results 41 to 50 of about 5,663,878 (222)

Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis

HYPERTENSION, 2022
Background: Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear. Methods: We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials.
A. Leung, C. Symonds, G. Hundemer, P. Ronksley, D. Lorenzetti, J. Pasieka, A. Harvey, G. Kline   +7 more
semanticscholar   +1 more source

Screening Rates for Primary Aldosteronism among Individuals with Hypertension plus Hypokalemia: A Population-Based Retrospective Cohort Study

HYPERTENSION, 2021
Supplemental Digital Content is available in the text. Primary aldosteronism is a common, yet highly underdiagnosed, cause of hypertension that leads to disproportionately high rates of cardiovascular disease. Hypertension plus hypokalemia is a guideline-
G. Hundemer, Haris Imsirovic, A. Vaidya, Nicholas Yozamp, R. Goupil, F. Madoré, M. Agharazii, G. Knoll, M. Sood   +8 more
semanticscholar   +1 more source

Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism [PDF]

, 2020
Context!#!Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.!##!Patients and methods!#!We assessed bone turnover in
Braun, Leah T., Bidlingmaier, Martin, Heinrich, Daniel A., Sturm, Lisa, Schneider, Holger, Künzel, Heike, Handgriff, Laura, Adolf, Christian, Fuss, Carmina T., Hahner, Stefanie, Reincke, Martin   +10 more
core   +1 more source

Genetics of Primary Aldosteronism

HYPERTENSION, 2022
Primary aldosteronism is considered the commonest cause of secondary hypertension. In affected individuals, aldosterone is produced in an at least partially autonomous fashion in adrenal lesions (adenomas, [micro]nodules or diffuse hyperplasia). Over the
U. Scholl
semanticscholar   +1 more source

Diagnosis and Treatment of Primary Aldosteronism in 2017: Did We Achieve Our Goals? [PDF]

, 2017
For many decades primary aldosteronism (PA) was dismissed as a rare endocrine condition, but is nowadays widely accepted as the most frequent endocrine cause of hypertension, largely due to the widespread use of the aldosterone-to-renin ratio as a ...
Tracy Ann Williams, Beuschlein, Felix, Felix Beuschlein, Martin Reincke, Beuschlein, Felix; https://orcid.org/, Williams, Tracy Ann, Reincke, Martin; https://orcid.org/, Williams, Tracy Ann; https://orcid.org/, Reincke, Martin   +8 more
core   +1 more source

The Unrecognized Prevalence of Primary Aldosteronism

Annals of Internal Medicine, 2020
Background: Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease. Objective: To characterize the prevalence of nonsuppressible renin-independent aldosterone production, as
Jenifer M. Brown, M. Siddiqui, D. Calhoun, R. Carey, P. Hopkins, G. Williams, A. Vaidya   +6 more
semanticscholar   +1 more source

Outcomes of a Specialized Clinic on Rates of Investigation and Treatment of Primary Aldosteronism.

JAMA Surgery, 2021
Importance Primary aldosteronism (PA) is one of the most common causes of secondary hypertension but remains largely unrecognized and untreated. Objective To understand the outcomes of a specialized clinic on rates of evaluation and treatment of PA in ...
Yuan-yuan Liu, J. King, G. Kline, R. Padwal, J. Pasieka, Guanmin Chen, Benny So, A. Harvey, A. Chin, A. Leung   +9 more
semanticscholar   +1 more source

The Primary Aldosteronism Surgical Outcome Score for the Prediction of Clinical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism [PDF]

, 2019
MINI: Clinical remission after unilateral adrenalectomy to treat unilateral primary aldosteronism is achieved in less than half of patients. A linear discriminant model with 6 presurgical predictors of clinical remission was used to build a 25-point ...
Quinkler, Marcus, Lenders, Jacques W. M., Prejbisz, A., Nishikawa, T., Burrello, J., Stowasser, M., Mulatero, P., Williams, T.A., Mulatero, Paolo, Reincke, M., Satoh, Fumitoshi, Burrello, A., Prejbisz, Aleksander, Burrello, Jacopo, Stowasser, Michael, Lenders, J.W.M., Satoh, F., Nishikawa, Tetsuo, Quinkler, M., Lenders, Jacques W M, Burrello, Alessio, Williams, Tracy Ann, Reincke, Martin   +22 more
core   +1 more source

Primary Aldosteronism: Where Are We Now? Where to From Here?

HYPERTENSION, 2022
Primary aldosteronism, the most common secondary form of hypertension, is thought to be present in ≈5% to 10% of hypertensive adults. However, recent studies indicate that its prevalence may be at least 3-fold higher based on the identification of renin ...
J. Funder, R. Carey
semanticscholar   +1 more source

Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism [PDF]

, 2020
Importance Most patients with primary aldosteronism, a major cause of secondary hypertension, are not identified or appropriately treated because of difficulties in diagnosis and subtype classification. Applications of artificial intelligence combined
Lenders, Jacques W. M., Eisenhofer, Graeme, Beuschlein, F., Burrello, J., Januszewicz, Andrzej, Mulatero, P., Peitzsch, M., Cannistraci, Carlo Vittorio, Buffolo, Fabrizio, Januszewicz, A., Durán, Claudio, Burrello, Jacopo, Riester, Anna, Cannistraci, Carlo, Williams, Tracy Ann, Peitzsch, Mirko, Williams, T. A., Prejbisz, A., Williams, T.A., Buffolo, F., Mulatero, Paolo, Reincke, M., Cannistraci, C.V., Prejbisz, Aleksander, Beuschlein, Felix, Riester, A., Lenders, J.W.M., Eisenhofer, G., Lenders, Jacques W M, Reincke, Martin, Durán, C.   +30 more
core   +1 more source