Results 61 to 70 of about 4,504,450 (222)

Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism [PDF]

, 2019
Primary aldosteronism is a common form of endocrine hypertension mainly caused by a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH).
Nirschl, Nina, Williams, T. A., Bidlingmaier, Martin, Burrello, J., Philippe, Aurélie, Yang, Yuhong, Hübener, Christoph, Rank, Petra, Beuschlein, Felix, Burrello, Jacopo, Sturm, Lisa, Jaquin, Diana, Williams, Tracy Ann, Dragun, Duska, Reincke, Martin   +14 more
core   +1 more source

Predictive score for the diagnosis of primary aldosteronism.

, 2022
Predictive score for the diagnosis of primary aldosteronism.
Pichitchai Atthakomol (7878608), Natthanan Tacharearnmuang (13205863), Worapaka Manosroi (2296279)   +2 more
core   +1 more source

New advances in the diagnosis of primary aldosteronism

Chronic Diseases and Translational Medicine, 2020
Primary aldosteronism (PA) is a common form of endocrine hypertension. The diagnostic process of PA includes a screening test, confirmatory test, and subtype classification.
Hang Shen, Zhi-Xin Xu, Qi-Fu Li
doaj   +1 more source

Histopathological stratification of primary aldosteronism using the CYP11B2 size ratio: first evaluation in clinical routine

Histopathology, EarlyView.
CYP11B2 immunohistochemistry identifies aldosterone‐producing nodules and enables objective subtyping using the B2 ratio (B2R), defined as the size ratio between the largest and second‐largest CYP11B2‐positive nodules. A B2R ≥8.1 indicates classical histology with a dominant lesion and high likelihood of cure, whereas B2R <8.1 reflects non‐classical ...
Adam Stenman, Tim Nilsson, Henrik Falhammar, C. Christofer Juhlin   +3 more
wiley   +1 more source

Activation of aldosterone secretion in primary aldosteronism [PDF]

Journal of Clinical Investigation, 1969
Angiotensin infusion evokes marked increases in aldosterone secretion in primary aldosteronism and little change in secondary aldosteronism. The low plasma renin activity of primary aldosteronism and the elevated plasma renin activity of secondary aldosteronism are thought to account for this differential response.
R F, Spark, S L, Dale, P C, Kahn, J C, Melby   +3 more
openaire   +2 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Primary aldosteronism in pregnancy

Reviews in Endocrine and Metabolic Disorders, 2022
AbstractPrimary aldosteronism (PA) is the most common form of secondary hypertension. Although hypertensive disorders seem to affect around 5–10% of pregnancies worldwide, literature counts less than 80 cases of PA diagnosed during the peri-partum period.
Forestiero, Vittorio, Sconfienza, Elisa, Mulatero, Paolo, Monticone, Silvia   +3 more
openaire   +2 more sources

Primary aldosteronism: Novel insights

, 2020
Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher than hypertensive individuals with equal blood pressure levels.
Faselis, C., Stavropoulos, K., Imprialos, K., Papademetriou, V., Doumas, M., Tsioufis, K., Dimitriadis, K.   +6 more
core   +1 more source

Primary aldosteronism and obstructive sleep apnea: What do we know thus far?

Frontiers in Endocrinology, 2022
Both primary aldosteronism and obstructive sleep apnea are well-known causes of hypertension and contribute to increased cardiovascular morbidity and mortality independently.
Huai Heng Loh, Huai Heng Loh, Norlela Sukor   +2 more
doaj   +1 more source

Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK Biobank

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT Medication use is common in large‐scale population cohorts, and can modify phenotypic traits of interest. This can potentially bias effect estimates in genome‐wide association studies (GWAS) and impact downstream analyses such as Mendelian randomisation (MR). The best approach to account for medication use in GWAS is unclear. In this study, we
Aaron Jun Yi Yap, Aimee L. Hanson, Gareth J. Griffith, Eleanor Sanderson   +3 more
wiley   +1 more source