Results 81 to 90 of about 5,663,878 (222)

Mineralocorticoid receptor antagonists: Efficacy and safety in chronic kidney disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3568-3581, May 2026.
Abstract The mineralocorticoid receptor (MR) has a multifaceted role in normal physiologic functions. However, research has uncovered the deleterious consequences of overactivation of the MR. It has been implicated in chronic kidney disease (CKD) via its strong association with glomerulosclerosis, interstitial fibrosis, proteinuria, and decline in ...
Amy K. Mottl, Kamlesh Khunti, Chantal Mathieu   +2 more
wiley   +1 more source

Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]

, 2009
<b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Freel, E.M., Latini, R., Connell, J.M.C., Tsorlalis, I.K., Lewsey, J.D., McMurray, J.J.V., Pitt, B., Maggioni, A.P., Solomon, S.   +8 more
core   +1 more source

Primary Aldosteronism in Patients in China With Recently Detected Hypertension.

Journal of the American College of Cardiology, 2020
BACKGROUND A total of 44.7% adults in China have hypertension, but the prevalence of primary aldosteronism (PA) in Chinese hypertensive patients is unknown.
Zhixin Xu, Jun Yang, Jinbo Hu, Ying Song, Wenwen He, Ting Luo, Q. Cheng, Linqiang Ma, R. Luo, P. Fuller, Jun Cai, Qifu Li, Shumin Yang   +12 more
semanticscholar   +1 more source

[Primary aldosteronism].

Revista medica de Chile, 2008
7
Fardella, Carlos E., Mosso, Lorena M., Carvajal, Cristian A.   +2 more
openaire   +5 more sources

Success Rate of Adrenal Venous Sampling and the Location of Right Adrenal Vein Orifice: A Retrospective Study

The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
ABSTRACT Adrenal venous sampling (AVS) is the gold standard for identifying aldosterone‐producing adenoma and bilateral adrenal hyperplasia. This study reports the success rate of AVS and the distribution characteristics of the right adrenal vein orifice (RAVO). The data of 166 patients with primary hyperaldosteronism who underwent AVS in Fuwai Central
Min‐Fu Bai, Jia‐Jia Dong, Xiao‐Mo Yang, Xiao‐Hui Wang, Yong‐Mei Liu, Chuan‐Yu Gao, Qiu‐Ping Zhao   +6 more
wiley   +1 more source

Within-patient reproducibility of the aldosterone: renin ratio in primary aldosteronism.

, 2010
The plasma aldosterone concentration:renin ratio (ARR) is widely used for the screening of primary aldosteronism, but its reproducibility is unknown. We, therefore, investigated the within-patient reproducibility of the ARR in a prospective multicenter ...
Letizia C., Mannelli M., Rossi E, Ferri C, Mantero F, Desideri G., Rossi GP, Caridi G, SECCIA RM, RIZZONI, Damiano, Desideri G, Giacchetti G., Mantero F. Primary Aldosteronism in the Prevalence in hYpertension Study Investigators, Seccia T.M., FABRIS, BRUNO, Seccia TM, BERNINI, GIAMPAOLO, Belfiore A., MANTERO F., Ferri C., Letizia C, Patalano A, FERRI, CLAUDIO, Rossi E., Primary Aldosteronism in the Prevalence in hYpertension Study Investigators, Palumbo G, Rossi G.P., Bernini G., Belfiore A, Mallamaci F, Rizzoni D., Patalano A., Caridi G., Mallamaci F., RIZZONI D, Mannelli M, Pessina AC, Fabris B, Palumbo G., Maccario M, Mallamaci, Pessina A.C., DESIDERI, GIOVAMBATTISTA, Bernini G, Maccario M., Giacchetti G   +45 more
core   +1 more source

The Evolution of the Primary Aldosteronism Syndrome: Updating the Approach.

Journal of Clinical Endocrinology and Metabolism, 2020
CONTEXT New approaches are needed to address the evolution of the primary aldosteronism syndrome and to increase its recognition. Herein, we review evidence indicating that primary aldosteronism is a prevalent syndrome that is mostly unrecognized, and ...
A. Vaidya, R. Carey
semanticscholar   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Treatment of Primary Aldosteronism with mTORC1 Inhibitors [PDF]

, 2019
mTORC1 activity is often increased in the adrenal cortex of patients with primary aldosteronism and mTORC1 inhibition decreases aldosterone production in adrenocortical cells, suggesting the mTORC1 pathway as a possible target for treatment of primary ...
Seelig, Eleonora, Kratschmar, Denise V, Donath, Marc Y., Trinh, Beckey, Hall, Michael N, Kratschmar, Denise V., Betz, Matthias J, Meienberg, Fabian, Swierczynska, Marta M., Hall, Michael N., Beuschlein, Felix, Donath, Marc Y, Hepprich, Matthias, Cavelti-Weder, Claudia, Betz, Matthias J., Odermatt, Alex, Beuschlein, Felix; https://orcid.org/, Swierczynska, Marta M, Burkard, Thilo, Reincke, Martin   +19 more
core   +1 more source

Prevalence of Hypokalemia and Primary Aldosteronism in 5100 Patients Referred to a Tertiary Hypertension Unit

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Primary aldosteronism (PA) was considered a rare disorder almost always associated with hypokalemia. The widespread screening of patients with hypertension unveiled an increased prevalence of PA with
J. Burrello, S. Monticone, I. Losano, Giovanni Cavaglià, F. Buffolo, M. Tetti, M. Covella, F. Rabbia, F. Veglio, B. Pasini, T. Williams, P. Mulatero   +11 more
semanticscholar   +1 more source