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Science, 1992
In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine leads to stress-induced deaths and devalued meat products. Abnormalities in the Ca
D H, MacLennan, M S, Phillips
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In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine leads to stress-induced deaths and devalued meat products. Abnormalities in the Ca
D H, MacLennan, M S, Phillips
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ASA Refresher Courses in Anesthesiology, 1980
In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability.
Gerald A. Gronert, Bryan E. Marshall
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In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability.
Gerald A. Gronert, Bryan E. Marshall
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Journal of Toxicology: Clinical Toxicology, 1996
Animal and human laboratory studies suggest marijuana may cause hyperthermia. However, there are no clinical case reports of life-threatening hyperthermia associated with use of marijuana alone.We report a patient who developed severe hyperthermia after smoking a marijuana cigarette and jogging on a warm day.
F G, Walter +3 more
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Animal and human laboratory studies suggest marijuana may cause hyperthermia. However, there are no clinical case reports of life-threatening hyperthermia associated with use of marijuana alone.We report a patient who developed severe hyperthermia after smoking a marijuana cigarette and jogging on a warm day.
F G, Walter +3 more
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Annals of Emergency Medicine, 1987
Malignant hyperthermia is a hereditary trait characterized by hypercatabolic reactions induced by anesthetic drugs, or physical or emotional stress. Patients must be treated quickly and efficiently in order to prevent irreversible organ damage and death.
J L, Tomarken, B A, Britt
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Malignant hyperthermia is a hereditary trait characterized by hypercatabolic reactions induced by anesthetic drugs, or physical or emotional stress. Patients must be treated quickly and efficiently in order to prevent irreversible organ damage and death.
J L, Tomarken, B A, Britt
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American Journal of Critical Care, 1997
Malignant hyperthermia is a pharmacogenetic disease of skeletal muscle characterized by hypermetabolism that occurs on exposure to a triggering agent or agents. The most common agents are halogenated inhalational anesthetics and succinylcholine, a depolarizing muscle relaxant.
A D, Miranda +3 more
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Malignant hyperthermia is a pharmacogenetic disease of skeletal muscle characterized by hypermetabolism that occurs on exposure to a triggering agent or agents. The most common agents are halogenated inhalational anesthetics and succinylcholine, a depolarizing muscle relaxant.
A D, Miranda +3 more
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Southern Medical Journal, 1983
Malignant hyperthermia, a rapidly progressive, frequently lethal syndrome was not described until quite recently. Although treatment with the drug dantrolene has changed its face, a clear understanding and deep respect for the syndrome are necessary to keep fatalities and tragic sequelae to a minimum.
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Malignant hyperthermia, a rapidly progressive, frequently lethal syndrome was not described until quite recently. Although treatment with the drug dantrolene has changed its face, a clear understanding and deep respect for the syndrome are necessary to keep fatalities and tragic sequelae to a minimum.
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Hyperthermia-induced seizures: Development of hyperthermia-prone and hyperthermia-resistant rats
Epilepsy Research, 2013Febrile seizures (FS), as a multifactorial and genetic disease, are the most common type of convulsive event in infants and young children. Their genetic basis, however, remains elusive. To investigate the genetic mechanisms involved in FS and to identify novel susceptibility genes, we developed two new strains of rats that are hyperthermia-prone (HP ...
Jian, Xu +9 more
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Malignant Hyperthermia or Not Malignant Hyperthermia
ICU Director, 2013In an acute event, the diagnosis of malignant hyperthermia (MH) in patients in the ICU can be challenging. Initial presentation may be attributed to a gamut of causes, making the diagnosis complicated. This example is the case of a 46-year-old African American man who was admitted to the Stroke Service and intubated for respiratory distress.
Alexander F. Bautista +1 more
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Hyperthermia and thermochemotherapy
1993The combination of anticancer drugs with hyperthermia was only recently introduced as an experimental clinical strategy. This approach within the field of medical oncology is based on the convincing evidence that hyperthermia enhances the therapeutic effect of several chemotherapeutic agents, even in drug-resistant cells. Such a combined modality is of
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The Italian Journal of Neurological Sciences, 1992
We describe the pathogenesis and the typical clinical and laboratory features of the hyperthermia syndromes that may develop during neuroleptic drug treatment, environmental exposure or following the use of inhalational anesthetics. Since the features are similar and confusion is possible we emphasize the need for prompt diagnosis so that appropriate ...
AMORE, MARIO, CERISOLI M.
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We describe the pathogenesis and the typical clinical and laboratory features of the hyperthermia syndromes that may develop during neuroleptic drug treatment, environmental exposure or following the use of inhalational anesthetics. Since the features are similar and confusion is possible we emphasize the need for prompt diagnosis so that appropriate ...
AMORE, MARIO, CERISOLI M.
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