Results 101 to 110 of about 103,321 (345)

Hypertriglyceridemia: new approaches in management and treatment

Current Opinion in Lipidology, 2020
Purpose of review Hypertriglyceridemia (HTG), a form of dyslipidemia characterized by elevated plasma of triglycerides (TG), is associated with an increased risk for acute pancreatitis.
A. Wolska, Zhi-Hong Yang, A. Remaley
semanticscholar   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

Asparaginase-Induced Hypertriglyceridemia Presenting as Pseudohyponatremia during Leukemia Treatment

Case Reports in Pediatrics, 2014
Asparaginase is a chemotherapeutic agent used to induce disease remission in children with acute lymphoblastic leukemia (ALL). We describe the cases of two females with ALL who developed pseudohyponatremia as a presentation of hypertriglyceridemia ...
Ashley Hinson, Dorothee Newbern, Corinne M. Linardic   +2 more
doaj   +1 more source

Histogram-based Sub-classification of Serum Triglycerides and Hypertriglyceridemia Prevalence Across Gender and Age Groups: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The ICMR-Indiab study (2014) and National Centres for Environmental Prediction (NCEP) (2001) guidelines recommended a healthy cut-off for serum triglycerides of
Chekkara Muthu Shaima, Jose Jacob
doaj   +1 more source

Does A Short, Thick Neck Predict Obstructive Sleep Apnea?: The Role of Physical Examination in OSA Screening [PDF]

, 2016
Purpose: The purpose of this study was to determine whether a short neck, alone or together with a thick neck, can predict obstructive sleep apnea (OSA).
Daskalakis, Sc.D., Constantine, Grewal, MD, Ritu G., Mangione, MD, Salvatore, Punati, MD, Ramya, Saxena, MD, Shivan   +4 more
core   +1 more source

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. [PDF]

, 2016
PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age
Allen, Shelly, DuBois, Steven G, Gustafson, W Clay, Hollinger, Fabienne, Karski, Erin E, Long-Boyle, Janel R, Matthay, Katherine K, Nasholm, Nicole M, Shiboski, Stephen, Vo, Kieuhoa T   +9 more
core   +1 more source

Plasmapheresis in Acute Hypertriglyceridemia‐Induced Pancreatitis—The PHIP‐JuGa‐Study

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The incidence of acute pancreatitis is increasing in the Western world. About 10% of cases are caused by hypertriglyceridemia. Plasmapheresis was shown to reduce serum triglyceride (TG) levels, and current apheresis guidelines recommend its use in severe acute hypertriglyceridemia‐induced pancreatitis (HIP).
Jonas J. Staudacher, Elisabeth Blüthner, Katharina Murillo, Manja Boldt, Karim Hamesch, Leah Kruse, Sabrina Sulzer, Christoph Ammer‐Herrmenau, Yvonne Huber, Julia Weinmann‐Menke, Charlotte Kramer, Jakob Garbe, Rene Wilke, Marcus M. Mücke, Myriam W. Heilani, Elisabeth Orgler‐Gasche, Marlies Vornhülz, Georg Beyer, Lara Wiesehahn, Annekatrin Schwanstecher, Marcus Hollenbach, Hendrik Luxenburger, Dominik Bettinger, Sophie Schlosser‐Hupf, for the JuGa study group   +24 more
wiley   +1 more source

Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats [PDF]

, 2010
We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total ...
Bradamante, Vlasta, Lucić Vrdoljak, Ana, Macan, Marija, Radić, Božica, Vrkić, Nada   +4 more
core  

Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis [PDF]

, 2017
Background The objective of this systematic review was to determine the effectiveness and safety of propranolol compared to placebo or usual care for improving clinical relevant outcomes in severely burned patients (TBSA \u3e20%).
Ferrada, Paula, Foianini, Jorge Esteban, García-Perdomo, Herney Andrés, Gomez, Diego Andrés, Manzano-Nunez, Ramiro, Ordoñez Delgado, Carlos Alberto   +5 more
core   +3 more sources

Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Genetic determinants of severe hypertriglyceridemia include both common variants with small effects (assessed using polygenic risk scores) plus heterozygous and homozygous rare variants in
J. Dron, A. Dilliott, Arden Lawson, A. McIntyre, Brent D. Davis, Jian Wang, H. Cao, I. Movsesyan, M. Malloy, C. Pullinger, J. Kane, R. Hegele   +11 more
semanticscholar   +1 more source