Results 181 to 190 of about 85,025 (319)

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age‐declining cord‐specific enriched metabolites are identified as antiaging candidates, with a 5‐compound formula validated in proof‐of‐experiments to extend lifespan and healthspan in human cells and C. elegans.
JiaYu Liu, Shuai Jiang, YanYan Shen, RuiBo Wang, Zhi Jin, YanQing Cao, JinLiang Li, YanHong Liu, Qi Qi, Yue Guo, YunYing Wang, BoYang Xie, JunCheng Li, AiPing Cao, Yao Wang, ChunYan Yan, QiuYing Han, YingJie Zhu, Jing Peng, FangTing Dong, Xin Pan, XinHua He, Tao Zhou, AiLing Li, Kun He, Na Wang, WeiNa Zhang, Qing Xia   +27 more
wiley   +1 more source

Diabetic Ketoacidosis Unveiling Severe Hypertriglyceridemia and Acute Mild Pancreatitis: A Rare Initial Manifestation of Type 2 Diabetes Mellitus. [PDF]

Am J Case Rep
Adrejiya P, Shahi S, Lodhi A, Abubaker M, Vora J, Singh G, Anara C, Gorle S, Kanugula A.   +8 more
europepmc   +1 more source

Impact of age at first visit on glycolipid metabolism, bone metabolism, and fertility potential in patients with Klinefelter syndrome

Andrology, Volume 14, Issue 1, Page 122-131, January 2026.
Abstract Background Classic Klinefelter syndrome (KS) is characterized by one extra X chromosome (47, XXY), leading to hypergonadotropic hypogonadism and higher risk of alterations in glycolipid homeostasis, cardiovascular diseases, and low bone mineral density. Most frequently, KS is diagnosed in adulthood because of infertility.
Giordana Ferraioli, Andrea Graziani, Noemi Sagone, Andrea Di Nisio, Massimo Iafrate, Fabrizio Dal Moro, Alberto Ferlin, Andrea Garolla   +7 more
wiley   +1 more source

Multimodal Management of Extreme Hypertriglyceridemia in a Child with Recurrent Pancreatitis: Clinical Challenges and Solutions. [PDF]

J Clin Med
Spoială EL, Oltean C, Vasiliu I, Paduraru G, Danilă DC, Ghiga G, Țugui M, Butnariu LI, Cojocaru E, Trandafir LM.   +9 more
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D‐2570 in Healthy Subjects: A First‐in‐Human Phase I Study

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT D‐2570 selectively binds to the pseudokinase domain of tyrosine kinase 2, which mediates the downstream cytokine signaling pathways involved in immune regulation. The safety, tolerability, pharmacokinetics, and pharmacodynamics of D‐2570 were evaluated in a randomized, double‐blind, placebo‐controlled phase I study conducted in healthy Chinese
Meng Wang, Quanying Zhang, Zhe Shi, Ling Zhang, Jie Pan   +4 more
wiley   +1 more source

Severe Hypertriglyceridemia-Induced Pancreatitis Presenting With Diabetic Ketoacidosis in a Pediatric Patient. [PDF]

Cureus
Padilla AL, Davila Parrilla L, Agrait Gonzalez MF, Rosado A, Salcedo G.   +4 more
europepmc   +1 more source

Hypoadiponectinemia Is Associated with Insulin Resistance, Hypertriglyceridemia, and Fat Redistribution in Human Immunodeficiency Virus-Infected Patients Treated with Highly Active Antiretroviral Therapy [PDF]

, 2003
Carol Addy, Alina Gavrila, Sotirios Tsiodras, Kimberly G. Brodovicz, Adolf W. Karchmer, Christos S. Mantzoros   +5 more
openalex   +1 more source

HDL function and composition in atherothrombotic cardiovascular disease with very high HDL‐C

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
We investigated 49 individuals (mean age: 62 ± 2 years, 83% female) with very high HDL‐C (>80 mg/dL), including 23 with ASCVD. Despite matched HDL‐C levels, functional and compositional HDL features differed between groups. CEC differences became evident only after tertile stratification, with ASCVD participants overrepresented in the lowest tertile ...
Teresa Padro, Natàlia Muñoz‐García, Marta Fanlo‐Maresma, Virginia Esteve‐Luque, Paula Cabré‐Fernandez, Gemma Vilahur, Antoni Riera‐Mestre, Lina Badimon, Xavier Pintó   +8 more
wiley   +1 more source

Hypertriglyceridemia-Induced Acute Pancreatitis Associated with Ruxolitinib for Hemophagocytic Lymphohistiocytosis: A Case Report. [PDF]

Case Rep Oncol Med
Medina S, Ynalvez LA, Ali HR, Cabanillas ME, Hamzeh I, Kumar S, Palaskas N, Deswal A, Khalaf S.   +8 more
europepmc   +1 more source

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement [PDF]

, 2003
Hiraku Ono, Hitoshi Shimano, Hideki Katagiri, Naoya Yahagi, Hideyuki Sakoda, Yukiko Onishi, Motonobu Anai, Takehide Ogihara, Midori Fujishiro, Amelia Y.I. Viana, Yasushi Fukushima, Masahiko Abe, Nobuhiro Shojima, Masatoshi Kikuchi, Nobuhiro Yamada, Yoshitomo Oka, Tomoichiro Asano   +16 more
openalex   +1 more source