Results 51 to 60 of about 55,382 (272)

Understanding Hypertriglyceridemia: Integrating Genetic Insights [PDF]

Hypertriglyceridemia is an exceptionally complex metabolic disorder characterized by elevated plasma triglycerides associated with an increased risk of acute pancreatitis and cardiovascular diseases such as coronary artery disease.
Georgina Correia da Silva, Mara Alves, Laranjeira, F, Georgina Correia-da-Silva, Francisco Laranjeira, Alves, M   +5 more
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

INSIG1 influences obesity-related hypertriglyceridemia in humans [PDF]

, 2010
In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the ...
Carless, M., Blangero, J., Kissebah, A., Curran, J., Cole, R., Dyer, T. D., Curran, Joanne E., Carless, Melanie A., Olivier, M. (Michael), Dyer, T., Abraham, L., Moses, Eric, Martin, L. J. (Lisa J.), Gawrieh, S., Olivier, M., Zhang, Y., Baye, T., Smith, Edward M., Baye, T. M., Kissebah, Ahmed, Abraham, L. J., Moses, E. K. (Eric Keith), Martin, L., Smith, E.   +23 more
core   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

Hypertriglyceridemia-induced acute pancreatitis in preg- nancy

, 2012
Context Hypertriglyceridemia is a well known phenomenon of pregnancy occurring due to physiologic changes in sex hormone levels. Occasionally, it could lead to development of acute pancreatitis. Gestational hypertriglyceridemia-induced acute pancreatitis
Audrius Sileikis, Vytautas Karosas, Serpytis, Mindaugas, Jurate Dementaviciene, Mindaugas Serpytis, Sipylaite, Jurate, Sileikis, Audrius, Jurate Sipylaite, Tamosauskas, Rokas, Karosas, Vytautas, Kestutis Strupas, Rokas Tamosauskas, Strupas, Kestutis, Dementaviciene, Jurate   +13 more
core   +1 more source

A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats

Animal Models and Experimental Medicine, EarlyView.
Male Sprague–Dawley rats received a cholesterol‐rich high‐fat diet supplemented with vitamin D and propylthiouracil for 11 weeks. The model induced dyslipidemia (increased total cholesterol/low‐density lipoprotein, decreased triglycerides), inflammation (increased interleukin‐6 and serum amyloid A), hypercalcemia, and reduced circulating endothelial ...
Angélique Lewies, Vitaris Kodogo, Johannes Frederik Wentzel, Francis Edwin Smit   +3 more
wiley   +1 more source

High incidence of hypertriglyceridemia in a Brazilian cohort of people living with HIV/AIDS undergoing antiretroviral treatment in Belo Horizonte, 2001-2010

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Hypertriglyceridemia incidence should be estimated in HIV-infected patients after antiretroviral therapy (ART) initiation. METHODS: We retrospectively analyzed clinical data of HIV-infected adults at 3 public referral centers.
Cássia Cristina Pinto Mendicino, Letícia Pena Braga, Cristiane Aparecida Menezes de Pádua, Mark Drew Crosland Guimarães   +3 more
doaj   +1 more source

Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review

Archives of Endocrinology and Metabolism, 2017
SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels.
Mohammad Shafi Kuchay, Khalid J. Farooqui, Tarannum Bano, Manoj Khandelwal, Harmandeep Gill, Ambrish Mithal   +5 more
doaj   +1 more source

Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study

Journal of Translational Medicine, 2020
Background Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the risk of target organ damage ...
Yuan Zhang, Miaomiao Zhang, Xiawen Yu, Fengjiang Wei, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang, Wei-Dong Li   +8 more
doaj   +1 more source

Effect of hypertriglyceridemia on left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study

Frontiers in Cardiovascular Medicine, 2023
AimsUsing speckle tracking technology to investigate the effect of hypertriglyceridemia on the global longitudinal strain(GLS) of the left ventricle in patients with coronary heart disease in the early stage, and to explore the value of myocardial strain
Lin Na, Wenjing Cui, Xinqi Li, Jing Chang, Xin Xue   +4 more
doaj   +1 more source