Results 61 to 70 of about 98,812 (291)

An open‐label, single‐arm, multicenter, phase II trial of bireociclib as monotherapy for heavily pretreated HR‐positive, HER2‐negative advanced breast cancer patients: BRIGHT‐1 trial

Cancer Communications, EarlyView.
Abstract Background Bireociclib (XZP‐3287) is a novel selective cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies. BRIGHT‐1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced, recurrent or metastatic, hormone ...
Jiayu Wang, Qingyuan Zhang, Tao Sun, Huiping Li, Ying Cheng, Zhongsheng Tong, Huihui Li, Wei Li, Jingfen Wang, Yuee Teng, Xinhong Wu, Jing Cheng, Zhendong Chen, Zhengqiu Zhu, Li Wang, Mingming Liu, Xianghui Duan, Lingmei Xu, Binghe Xu   +18 more
wiley   +1 more source

Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review

Archives of Endocrinology and Metabolism, 2017
SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels.
Mohammad Shafi Kuchay, Khalid J. Farooqui, Tarannum Bano, Manoj Khandelwal, Harmandeep Gill, Ambrish Mithal   +5 more
doaj   +1 more source

Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease [PDF]

, 2018
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines.
Adina Alazraki, Ajay K. Jain, Alan Wells, Albert Hernandez, Alex Towbin, Ali Mencin, Alice Sternberg, Ann Klipsch, Ann Scheimann, April Carr, Averell Sherker, Bradley Aouizerat, Camille Langlois, Claude Sirlin, Craig Bross, Cynthia A. Behling, Cynthia Rigsby, Daniel Podberesky, David E. Kleiner, Debra King, Diana Lopez-Graham, Edward C. Doo, Elena Reynoso, Elizabeth M. Brunt, Emily Ragozzino, Emily Rothbaum Perito, Erin Hallinan, Evelyn Hsu, Gerald Behr, Girish Subbarao, Hannah Awai, James Tonascia, Janet Freebersyser, Janis Durelle, Jay H. Hoofnagle, Jay H. Lefkowitch, Jean P. Molleston, Jeanne M. Clark, Jeffrey B. Schwimmer, Jennifer Collins, Jesse Courtier, Jessica Cruz Munos, Jinping Lai, Joan Siegner, Joel E. Lavine, Jonathan A. Africa, Jose Derdoy, Joy Ito, Kara Cooper, Karen Murray, Katherine Yates, Kathleen Lake, Kathryn E. Harlow, Kathryn Fowler, Kevin P. May, Kim Cecil, Kimberlee Bernstein, Kimberly Kafka, Kimberly P. Newton, Kristin Bramlage, Kristina Wriston, Kumar Sandrasegaran, Laura Miriel, Laura Walker, Laura Wilson, Leanel Maldonado, Linda D. Ferrell, Lisa Sharda, Lixin Zhu, Maria Cordero, Mariana Dominguez Villarreal, Mark H. Fishbein, Mark Van Natta, Matthew Yeh, Melissa Paiz, Melissa Young, Michael Middleton, Michele Donithan, Milana Isaacson, Miriam B. Vos, Molly Bozic, Natasha Feier, Nicholas Raviele, Oscar W. Cummings, Pat Osmack, Patricia H. Belt, Patricia R. Robuck, Patricia Ugalde-Nicalo, Patrika Tsai, Peter F. Whitington, Philip Rosenthal, Rajesh Krisnamurthy, Randolph Otto, Rebecca Cleeton, Rebecca Torrance, Rohit Kohli, Rory Mahabir, Ryan Gill, Ryan Himes, Saeed Mohammad, Sarah Barlow, Sarah Barlow, Saul Karpen, Sherry Brown, Simon Horslen, Sonja Williams, Stavra A. Xanthakos, Stephanie DeVore, Stephanie H. Abrams, Susan S. Baker, Susan Stewart, Susan Torretta, Theresa Cattoor   +112 more
core   +2 more sources

Actinidia spp. (Kiwifruit): A Comprehensive Review of Its Nutraceutical Potential in Disease Mitigation and Health Enhancement

Food Frontiers, EarlyView.
Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha, Nida Rehman, Rimsha Anwar, Hina Rasheed, Roshina Rabail, Zuhaib F. Bhat, Amin Mousavi Khaneghah, Rana Muhammad Aadil   +7 more
wiley   +1 more source

Low-Grade Inflammation in the Association between Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis: A Study of More Than 115000 Individuals from the General Population.

Clinical Chemistry, 2019
BACKGROUND How mild-to-moderate hypertriglyceridemia (2-10 mmol/L; 177-886 mg/dL) potentially causes acute pancreatitis is unknown; however, cellular studies indicate that inflammation might be a driver of disease progression.
Signe E. J. Hansen, C. M. Madsen, A. Varbo, B. Nordestgaard   +3 more
semanticscholar   +1 more source

The prevalence of cardiovascular disease risk factors in patients from Croatian Zagorje County treated at Department of Medicine, Zabok General Hospital from 2000 to 2006 [PDF]

, 2007
The aim of the study was to assess the prevalence of risk factors for cardiovascular disease in patients treated for coronary heart disease (CHD) at Department of Medicine, Zabok General Hospital during the 2000-2006 period. Cardiovascular diseases are a
Buković, Damir, Fureš, Rajko, Pešek, Ksenija, Pešek, Tomislav, Radoš, Marko, Ćuk, Višeslav   +5 more
core  

Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study [PDF]

, 2018
Purpose In this multicenter study, we evaluated the cumulative burden of morbidity (CBM) among > 1,200 testicular cancer survivors and applied factor analysis to determine the co-occurrence of adverse health outcomes (AHOs).
AnnaLynn M. Williams, Christian Kollmannsberger, Chunkit Fung, Clair Beard, Darren R. Feldman, David J. Vaughn, Deepak M. Sahasrabudhe, Howard D. Sesso, Jeri Kim, Lawrence H. Einhorn, Lois B. Travis, Mohammad I. Abu Zaid, null null, Patrick O. Monahan, Robert A. Huddart, Robert J. Hamilton, Ryan Cook, Sarah L. Kerns, Shirin Ardeshir-Rouhani-Fard, Sophie D. Fossa, Timothy E. Stump   +20 more
core   +1 more source

PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance

PPAR Research, 2016
Hypertriglyceridemia is an important risk factor associated with insulin resistance and β-cell dysfunction. This study investigated the effects of hypertriglyceridemia and fenofibrate treatment on insulin sensitivity and β-cell function in subjects with ...
Jia Liu, Rui Lu, Ying Wang, Yanjin Hu, Yumei Jia, Ning Yang, Jing Fu, Guang Wang   +7 more
doaj   +1 more source

Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

Hepatology, 2018
Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid ...
L. Goedeke, J. Bates, D. Vatner, R. Perry, Ting Wang, Ricardo Ramírez, Li Li, Matthew W. Ellis, Dongyan Zhang, Kari E. Wong, C. Beysen, G. Cline, A. Ray, G. Shulman   +13 more
semanticscholar   +1 more source

The association between cardiorespiratory fitness and cardiometabolic risk in children is mediated by abdominal adiposity: the HAPPY study [PDF]

, 2014
Background: It is unclear whether cardiorespiratory fitness (CRF) is independently linked to cardiometabolic risk in children. This study investigated a) the association between CRF level and presence of cardiometabolic risk disorders using health ...
Bailey, Daniel Paul, Denton, Sarah J., Kerr, Catherine J., Savory, Louise A.   +3 more
core   +1 more source