Results 131 to 140 of about 193,158 (291)

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy

JACC: Advances
Background: Alcohol septal ablation (ASA) may necessitate a repeat procedure if the obstructive myocardium is not sufficiently ablated; however, the outcomes after repeat ASA are not well studied.
Takashi Hiruma, MD, Mitsunobu Kitamura, MD, Itaru Takamisawa, MD, Ryo Abe, MD, Tosei Kawai, MD, Takashi Funaki, MD, Yuki Izumi, MD, Ryosuke Higuchi, MD, Junya Matsuda, MD, Yukichi Tokita, MD, Mamoru Nanasato, MD, Nobuo Iguchi, MD, Tomohiro Iwakura, MD, Tomoki Shimokawa, MD, Shuichiro Takanashi, MD, Hiroo Takayama, MD, PhD, Yuichi J. Shimada, MD, MPH, Hitoshi Takano, MD, Kuniya Asai, MD, Mitsuaki Isobe, MD, Morimasa Takayama, MD   +20 more
doaj   +1 more source

Management of stiff hypertrophic nonunions by distraction osteogenesis - A report of 16 cases

, 2003
Objective: Hypertrophic nonunions can be managed successfully with distraction. Hypertrophic changes indicate that the tissue at the nonunion site has a biologic healing potential.
Cakmak, M, Dincyurek, H, Eralp, L, Sen, C, Kocaoglu, M, Goksan, SB   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Hypertrophic Osteoarthropathy

Journal of Osteopathic Medicine, 2015
Sean, Carlson, John, Rauchenstein
openaire   +2 more sources

Hypertrophic lupus vulgaris : An unusual presentation

, 2009
Lupus vulgaris is the most common form of cutaneous tuberculosis occurring in previously sensitized individuals with a high degree of tuberculin sensitivity. Various forms including plaque, ulcerative, hypertrophic, vegetative, papular, and nodular forms
Jain Vijay, Singh Sunita, Jain Sarika, Aggarwal Kamal   +3 more
core  

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Exosome‐mimetic vesicle‐encapsulated multi‐responsive antibacterial hydrogel core‐shell microneedle patch promotes scarless healing of infected wounds

BMEMat, EarlyView.
The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang, Huihui Zhang, Lianglong Chen, Zhangfeifan Yang, Sai Cao, Yufang He, Xiaoyang Liu, Siew Yee Wong, Xu Li, Hai Zhou, Ziyan Li, Zijun Zheng, Lei Yang   +12 more
wiley   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source