Results 101 to 110 of about 128,678 (309)

Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Jiri Bonaventura, Ethan J. Rowin, Martin S. Maron, Barry J. Maron   +3 more
doaj   +1 more source

Cardiovascular Hospitalizations Burden Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Longer‐term morbidity post septal myectomy (SM) in obstructive hypertrophic cardiomyopathy has not been well characterized at a national level.
Ahmed Altibi, Miriam Elman, Hailey Volk, Mohammad Alqabani, Michael Butzner, Howard Song, Ahmad Masri   +6 more
doaj   +1 more source

Inter-observer variability for cardiac ultrasound measurements in cats repeated at different time points in early adult life [PDF]

, 2018
A high degree of accuracy is required when using echocardiography to diagnose hypertrophic cardiomyopathy (HCM) in cats, as variation in measurements of 0.5 mm may affect classification of individuals as ‘abnormal’.
Barberet, Chetboul, Gundler, Hansson, Payne, Simpson, Wagner, Wolf   +7 more
core   +2 more sources

Gene List Selection Matters: Missed Diagnoses in Prenatal Exome Sequencing—PanelApp R21 and HPO‐Driven Versus OMIM‐Based Gene Lists

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate whether the causative variants found upon clinical exome sequencing in fetuses affected with selected structural anomalies would also be detected if PanelApp‐R21 or Human Phenotype Ontology (HPO)‐driven gene selection terms were applied instead.
Victoria Ardiles‐Ruesjas, Laia Rodriguez‐Revenga, Montse Pauta, Alfons Nadal, Gemma Arca, Laura Gort, Stiven Ernesto Sinisterra‐Díaz, Antoni Borrell   +7 more
wiley   +1 more source

An integration-free iPSC line ZZUNEUi028-A derived from a patient with hypertrophic cardiomyopathy carrying a heterozygous mutation (c. 1504 C > T) in MYBPC3 gene

, 2022
Dong Cheng, Shengye Zhang, Xiaowei Li, Lu Wang, Jianzeng Dong, Haiqiang Sang   +5 more
openalex   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T [PDF]

, 2012
Christopher R. Bayliss, Adam Jacques, Man-Ching Leung, Douglas G. Ward, Charles Redwood, Clare E. Gallon, O’Neal Copeland, William J. McKenna, Cristobal G. dos Remedios, Steven B. Marston, Andrew E. Messer   +10 more
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Enhancing explainability in clinical deep-learning models: Latent-space variable decoding is superior to gradient-weighted class activation mapping

Heart Rhythm O2
Background: Deep-learning models designed to assist with clinical decision making abound in cardiology. However, the “black box” nature of these models limits physicians’ ability to use them to cross-check clinical gestalt when evaluating model ...
Richard T. Carrick, MD, PhD, Ethan J. Rowin, MD, Alessio Gasperetti, MD, PhD, Christopher Madias, MD, Martin Maron, MD, Katherine C. Wu, MD   +5 more
doaj   +1 more source