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Nature Reviews Disease PrimersHypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and represents a leading cause of morbidity and mortality. HCM is a sarcomeric disease characterized by genetically determined defects in sarcomere proteins, leading to left ventricular hypertrophy, hypercontractility and diastolic dysfunction.
Alessia Argirò +6 more
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The Lancet, 2013
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant, cardiovascular disorder that carries the risk of sudden cardiac death. The prevalence of HCM is 1:500 persons. The purpose of this article is to provide an overview of the pathophysiology, symptoms, complications, diagnostic testing, and treatment.
Angelos G, Rigopoulos, Hubert, Seggewiss
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Hypertrophic cardiomyopathy (HCM) is an autosomal dominant, cardiovascular disorder that carries the risk of sudden cardiac death. The prevalence of HCM is 1:500 persons. The purpose of this article is to provide an overview of the pathophysiology, symptoms, complications, diagnostic testing, and treatment.
Angelos G, Rigopoulos, Hubert, Seggewiss
+9 more sources
JAMA, 1999
The degree of clinical expression of both obstructive and nonobstructive hypertrophic cardiomyopathy (HCM) is widely variable. Many patients with HCM are asymptomatic or minimally symptomatic. Most patients with mild or moderate HCM respond well to medical therapy, but medical therapy in patients with severe disease is only marginally beneficial.
Maron, B J +8 more
openaire +5 more sources
The degree of clinical expression of both obstructive and nonobstructive hypertrophic cardiomyopathy (HCM) is widely variable. Many patients with HCM are asymptomatic or minimally symptomatic. Most patients with mild or moderate HCM respond well to medical therapy, but medical therapy in patients with severe disease is only marginally beneficial.
Maron, B J +8 more
openaire +5 more sources
Current Problems in Cardiology, 2004
Abstract The clinical definition of hypertrophic cardiomyopathy is left ventricular hypertrophy in the absence of other causes of left ventricular hypertrophy. The size and volume of the left ventricle are usually normal or smaller. Most cases are familial disease with autosomal dominant inheritance.
Steve R, Ommen, Rick A, Nishimura
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Abstract The clinical definition of hypertrophic cardiomyopathy is left ventricular hypertrophy in the absence of other causes of left ventricular hypertrophy. The size and volume of the left ventricle are usually normal or smaller. Most cases are familial disease with autosomal dominant inheritance.
Steve R, Ommen, Rick A, Nishimura
openaire +5 more sources
JAAPA, 2018
Hypertrophic cardiomyopathy is the most common inherited cardiovascular disease. It is characterized by increased ventricular wall thickness and is highly complex due to its heterogeneous clinical presentation, several phenotypes, large number of associated causal mutations and broad spectrum of complications.
Juan José, Santos Mateo +2 more
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Hypertrophic cardiomyopathy is the most common inherited cardiovascular disease. It is characterized by increased ventricular wall thickness and is highly complex due to its heterogeneous clinical presentation, several phenotypes, large number of associated causal mutations and broad spectrum of complications.
Juan José, Santos Mateo +2 more
openaire +4 more sources
Current Treatment Options in Cardiovascular Medicine, 2002
When an individual is diagnosed with hypertrophic cardiomyopathy (HCM), all relatives potentially affected by Mendelian autosomal-dominant inheritance should be evaluated with an electrocardiogram (ECG) and echocardiogram. Genetic testing should be considered in high-risk mutations where there are diagnostic uncertainties.
Elijah R., Behr, William J., McKenna
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When an individual is diagnosed with hypertrophic cardiomyopathy (HCM), all relatives potentially affected by Mendelian autosomal-dominant inheritance should be evaluated with an electrocardiogram (ECG) and echocardiogram. Genetic testing should be considered in high-risk mutations where there are diagnostic uncertainties.
Elijah R., Behr, William J., McKenna
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The Lancet, 1998
Hypertrophic cardiomyopathy is a common genetically transmitted disease, defined clinically by the presence of unexplained left ventricular hypertrophy. The disease has a varied clinical course and outcome; many patients have little or no discernible cardiovascular symptoms, whereas others have profound exercise limitation and recurrent arrhythmias ...
Perry, Elliott, William J, McKenna
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Hypertrophic cardiomyopathy is a common genetically transmitted disease, defined clinically by the presence of unexplained left ventricular hypertrophy. The disease has a varied clinical course and outcome; many patients have little or no discernible cardiovascular symptoms, whereas others have profound exercise limitation and recurrent arrhythmias ...
Perry, Elliott, William J, McKenna
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Cardiology in the Young, 1977
AbstractHypertrophic cardiomyopathy is a common, inherited heart disease with a heterogeneous clinical presentation and natural history. Recently, advances in diagnosis and treatment options have been instrumental in decreasing the frequency of adverse clinical events; however, complete elimination of sudden cardiac death still remains an elusive gain.
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AbstractHypertrophic cardiomyopathy is a common, inherited heart disease with a heterogeneous clinical presentation and natural history. Recently, advances in diagnosis and treatment options have been instrumental in decreasing the frequency of adverse clinical events; however, complete elimination of sudden cardiac death still remains an elusive gain.
openaire +4 more sources