Results 71 to 80 of about 270,350 (354)

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

Science Translational Medicine, 2019
Mutations in MYBPC3 disrupt myosin states of relaxation, and manipulating myosin therapeutically abates the effects of MYBPC3 mutations. Manipulating myosin to curb cardiomyopathy Hypertrophic cardiomyopathy (HCM, thickened heart muscle) is a disease ...
Christopher N Toepfer, H. Wakimoto, Amanda C Garfinkel, B. McDonough, Dan Liao, Jianming Jiang, Angela C. Tai, J. Gorham, I. Lunde, M. Lun, Thomas L Lynch, James W. McNamara, S. Sadayappan, C. Redwood, H. Watkins, J. Seidman, C. Seidman   +16 more
semanticscholar   +1 more source

Prognostic role of high‐sensitivity cardiac troponin T in patients with cardiac sarcoidosis: insights from ILLUMINATE‐CS

ESC Heart Failure, Volume 12, Issue 2, Page 869-878, April 2025.
Abstract Aims The prognostic role of high‐sensitivity cardiac troponin T (hs‐cTnT) as a biomarker in patients with cardiac sarcoidosis (CS) has yet to be fully determined, especially when compared with B‐type natriuretic peptide (BNP). Methods and Results In this post‐hoc analysis of the ILLUMINATE‐CS (ILLUstration of the Management and prognosIs of ...
Yuichi Baba, Toru Kubo, Takeru Nabeta, Yuya Matsue, Takeshi Kitai, Yoshihisa Naruse, Tatsunori Taniguchi, Hidekazu Tanaka, Takahiro Okumura, Kenji Yoshioka, Hiroaki Kitaoka   +10 more
wiley   +1 more source

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Pflügers Archiv: European Journal of Physiology, 2019
Several lines of evidence suggest that the primary effect of hypertrophic cardiomyopathy mutations in human β-cardiac myosin is hypercontractility of the heart, which leads to subsequent hypertrophy, fibrosis, and myofilament disarray.
J. Spudich
semanticscholar   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Hypertrophic Cardiomyopathy: An Overview of Genetics and Management

Biomolecules, 2019
Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle disorder with a diverse natural history, characterized by unexplained left ventricular hypertrophy (LVH), with histopathological hallmarks including myocyte enlargement ...
P. Teekakirikul, Wenjuan Zhu, Helen C. Huang, E. Fung   +3 more
semanticscholar   +1 more source

The genetics of hypertrophic cardiomyopathy

Global Cardiology Science and Practice, 2018
Hypertrophic cardiomyopathy (HCM) is most commonly transmitted as an autosomal dominant trait, caused by mutations in genes encoding cardiac sarcomere proteins. Other inheritable causes of the disease include mutations in genes coding for proteins important in calcium handling or that form part of the cytoskeleton. At present, the primary clinical role
Akhtar, M, Elliott, P
openaire   +5 more sources

A contemporary simple risk score for prediction of severe acute kidney injury after heart transplantation

ESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.
A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu, Weihua Qiao, Yixuan Wang, Ying Zhou, Yin Xu, Shijie Wang, Tian Xia, Guohua Wang, Si Chen, Jiawei Shi, Nianguo Dong   +10 more
wiley   +1 more source

Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

Nature Network Boston, 2023
A. C. Chai, Miao Cui, F. Chemello, Hui Li, Kenian Chen, Wei Tan, A. Atmanli, John R. McAnally, Yu Zhang, Lin Xu, Ning Liu, R. Bassel-Duby, E. Olson   +12 more
semanticscholar   +1 more source

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).

European Heart Journal, 2014
2D : two-dimensional 99mTc-DPD : 99mTechnetium-3,3-diphosphono- 1,2-propanodi-carboxylic acid ACE : angiotensin-converting enzyme AF : atrial fibrillation AL : amyloid light chain AR : aortic regurgitation ARB : angiotensin receptor blocker ATTR ...
Perry M. Elliott, A. Anastasakis, Michael A. Borger, M. Borggrefe, Franco Cecchi, Philippe Charron, A. Hagège, Antoine Lafont, G. Limongelli, Heiko Mahrholdt, William J. McKenna, Jens Mogensen, P. Nihoyannopoulos, Stefano Nistri, Petronella G. Pieper, Burkert Pieske, Claudio Rapezzi, Frans H. Rutten, Christoph Tillmanns, Hugh Watkins   +19 more
semanticscholar   +1 more source