Results 71 to 80 of about 222,830 (234)
Hypertrophic cardiomyopathy: genetics and clinical perspectives.
Cardiovascular Diagnosis and Therapy, 2019 Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic ventricular dysfunction, arrhythmias, sudden cardiac death and histopathologic ...
C. Wolf
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JAMA cardiology, 2019 Importance Racial differences are recognized in multiple cardiovascular parameters, including left ventricular hypertrophy and heart failure, which are 2 major manifestations of hypertrophic cardiomyopathy. The association of race with disease expression
L. Eberly +16 more
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The genetics of hypertrophic cardiomyopathy
Global Cardiology Science and Practice, 2018 Hypertrophic cardiomyopathy (HCM) is most commonly transmitted as an autosomal dominant trait, caused by mutations in genes encoding cardiac sarcomere proteins. Other inheritable causes of the disease include mutations in genes coding for proteins important in calcium handling or that form part of the cytoskeleton. At present, the primary clinical role
Akhtar, M, Elliott, P
openaire +5 more sources
Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice
Nature Network Boston, 2023 A. C. Chai +12 more
semanticscholar +1 more source
Genetics of hypertrophic cardiomyopathy: A review of current state
Clinical Genetics, 2018 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease. HCM is a highly complex and heterogeneous disease regarding not only the number of associated mutations but also the severity of phenotype, symptom burden, and the ...
M. Sabater-Molina +3 more
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CARDIOMYOPATHY: The diagnosis of hypertrophic cardiomyopathy [PDF]
Heart, 2001 Although the pathology of hypertrophic cardiomyopathy (HCM) was first described by French pathologists in the mid 19th century, it remained for the virtually simultaneous reports of Brock and Teare in England some 43 years ago to bring modern attention to this fascinating entity.1 2 Subsequent to these surgical1 and pathological2 observations, there ...
openaire +3 more sources
Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis
Journal of NanobiotechnologyBackground Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death.
Xueli Zhao +13 more
doaj +1 more source
Automatic Segmentation and Disease Classification Using Cardiac Cine MR Images [PDF]
arXiv, 2017 Segmentation of the heart in cardiac cine MR is clinically used to quantify cardiac function. We propose a fully automatic method for segmentation and disease classification using cardiac cine MR images. A convolutional neural network (CNN) was designed to simultaneously segment the left ventricle (LV), right ventricle (RV) and myocardium in end ...
arxiv
Diagnosis and Evaluation of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review.
Journal of the American College of Cardiology, 2022 B. Maron +8 more
semanticscholar +1 more source
HYPERTROPHIC CARDIOMYOPATHY: GENETIC ALTERATIONS, PATHOGENESIS AND PATHOPHYSIOLOGY
Российский кардиологический журнал, 2014 The review is dedicated to the description of genetic alterations, pathogenetic mechanisms and pathophysiology of hypertrophic cardiomyopathy, based on the analysis of current up to date information.
N. T. Vatutin +2 more
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