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Hypertrophic obstructive cardiomyopathy [PDF]
The Lancet, 2017 Hypertrophic obstructive cardiomyopathy is an inherited myocardial disease defined by cardiac hypertrophy (wall thickness ≥15 mm) that is not explained by abnormal loading conditions, and left ventricular obstruction greater than or equal to 30 mm Hg. Typical symptoms include dyspnoea, chest pain, palpitations, and syncope.
Josef Veselka +3 more
openaire +6 more sources
European Journal of Heart Failure, 2023 In the EXPLORER‐HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients.
E. Bertero +62 more
semanticscholar +1 more source
Echocardiography for hypertrophic obstructive cardiomyopathy
Annals of Cardiac Anaesthesia, 2017 Kalpna Irpachi +2 more
doaj +3 more sources
Effect of Mavacamten on Chinese Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy
JAMA cardiology, 2023 Key Points Question What is the effect of treatment with mavacamten on Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy? Findings In this phase 3 randomized clinical trial of 81 patients, mavacamten significantly improved ...
Z. Tian +15 more
semanticscholar +1 more source
Anatolian Journal of Cardiology, 2022 Background: Alcohol septal ablation is recommended for hypertrophic obstructive cardiomyopathy patients who had refractory symptoms despite optimal medical treatment.
Umut Karabulut +5 more
doaj +1 more source
Expanding the deep-learning model to diagnosis LVNC: Limitations and trade-offs [PDF]
Computer Methods in Biomechanics and Biomedical Engineering:
Imaging & Visualization. 2024, 2023 Hyper-trabeculation or non-compaction in the left ventricle of the myocardium (LVNC) is a recently classified form of cardiomyopathy. Several methods have been proposed to quantify the trabeculae accurately in the left ventricle, but there is no general agreement in the medical community to use a particular approach.
arxiv +1 more source
JAMA cardiology, 2022 Importance Patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-refractory symptoms and outflow gradients have limited nonsurgical treatment options. The feasibility of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA)
M. Zhou +20 more
semanticscholar +1 more source
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023 Currently, there are 2 proposed causes of acute left ventricular ballooning. The first is the most cited hypothesis that ballooning is caused by direct catecholamine toxicity on cardiomyocytes or by microvascular ischemia.
R. Citro +4 more
semanticscholar +1 more source
Review of Mavacamten for Obstructive Hypertrophic Cardiomyopathy and Future Directions
Drug Design, Development and Therapy, 2023 Hypertrophic cardiomyopathy (HCM) is a condition with abnormal hypertrophy of the left ventricle in the absence of common causes. The most common form involves the basal septum and can lead to obstruction of the left ventricular outflow tract.
Tiffany Dong +3 more
semanticscholar +1 more source
Heart International, 2022 Hypertrophic cardiomyopathy is the most common monogenic cardiovascular disease that is caused by sarcomeric protein gene mutations. A hallmark of the most common form of the disease is outflow obstruction secondary to systolic narrowing of the left ...
K. R. Reyes, Gizem Bilgili, F. Rader
semanticscholar +1 more source