Results 231 to 240 of about 196,988 (294)

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Characterising the phenotype and ‍outcomes of cascade-tested relatives of probands with ‍hypertrophic cardiomyopathy. [PDF]

Open Heart
Chaudhry WR, McWilliam C, Berg J, Choy AM.   +3 more
europepmc   +1 more source

Mineralocorticoid receptor antagonists: Efficacy and safety in chronic kidney disease

Diabetes, Obesity and Metabolism, EarlyView.
Abstract The mineralocorticoid receptor (MR) has a multifaceted role in normal physiologic functions. However, research has uncovered the deleterious consequences of overactivation of the MR. It has been implicated in chronic kidney disease (CKD) via its strong association with glomerulosclerosis, interstitial fibrosis, proteinuria, and decline in ...
Amy K. Mottl, Kamlesh Khunti, Chantal Mathieu   +2 more
wiley   +1 more source

Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway. [PDF]

J Cell Mol Med
Qiu RB, Wu ZM, Xu ZQ, Hu LJ, Zhao ST, Zeng RY, Qiu ZC, Zhou LF, Lai SQ, Wang WJ, Wan L.   +10 more
europepmc   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, EarlyView.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source

Chronic intermittent hypoxia exacerbates isoproterenol-induced cardiac hypertrophy and apoptosis. [PDF]

Front Cardiovasc Med
Zhang Y, Zhang M, Jiang H, Fang F.
europepmc   +1 more source

The use of exercise testing to assess training efficacy in sport horses

Equine Veterinary Education, EarlyView.
Summary Training programmes for horses must be tailored to the physiological demands of each Fédération Équestre Internationale (FEI) discipline to optimise performance and welfare. Standardised exercise tests (SETs) have emerged as essential tools for evaluating equine fitness by measuring physiological responses to controlled workloads.
E. W. Siegers, M. M. Sloet van Oldruitenborgh‐Oosterbaan, C. C. B. M. Munsters   +2 more
wiley   +1 more source

Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction. [PDF]

PLoS One
Kono Y, Sonoda K, Ohtake K, Ota A, Yamamoto S, Nakayama H, Fukuoka T, Kawai Y, Tago H, Watanabe N, Sato I, Hirohata S, Kitamori K, Watanabe S.   +13 more
europepmc   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Delayed bioprosthetic valve thrombosis after transcatheter aortic valve implantation in a patient with severe left ventricular diastolic dysfunction: A case report. [PDF]

BMC Cardiovasc Disord
Yuan S, Li J, Mou Y, Ni Y.
europepmc   +1 more source