Results 231 to 240 of about 140,079 (313)

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Impact of Anterior Mitral Leaflet Length on the Efficacy of Intracardiac Echocardiography-Guided Endocardial Septal Ablation for HOCM. [PDF]

J Cardiovasc Dev Dis
Ling Y, Yu T, Xu Y, Wan Q, Pang Y, Liu G, Chen C, Cheng K, Zhu W, Chen Q, Ge J.   +10 more
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Diagnostic Approach to Left Ventricular Hypertrophy: A Review. [PDF]

US Cardiol
Banthiya S, Agrawal A, Rai D, Chowdhury M, Pan S, Naidu SS.   +5 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Mosaic pathogenic <i>PRKAG2</i> variant and pathologic diagnosis of glycogen storage disease in an infant with negative whole-genome sequencing. [PDF]

JHLT Open
Cabido V, Huang Y, Halnon N, Fan J, Touma M, Fishbein GA, Husain M.   +6 more
europepmc   +1 more source

Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities

Hemodialysis International, EarlyView.
ABSTRACT Background Optimizing fluid and nutritional management is a cornerstone of care for children with end‐stage kidney disease on dialysis. Inaccurate assessment of hydration status contributes to hypertension, fluid overload, and increased cardiovascular risk, while masking important changes in muscle and fat compartments that affect growth and ...
Marisa Juarez‐Calderon, Jessica Geer, Molly Wong Vega   +2 more
wiley   +1 more source

Cardiac magnetic resonance assessment of left ventricular phenotypes and prognostic implications in hypertensive heart disease. [PDF]

Clin Hypertens
Lertsiripatarajit P, Wanitchung K, Prechawuttidech S, Tongsai S, Kaolawanich Y.   +4 more
europepmc   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review. [PDF]

BMC Cardiovasc Disord
Bobbio E, Caiazza M, Pisacane F, Viscovo I, Gentile A, Monda E, De Falco C, Esposito D, Borrelli F, Losi M, Bossone E, Chen SN, Frisso G, Calabrò P, Esposito G, Lombardi R, Limongelli G.   +16 more
europepmc   +1 more source