Results 31 to 40 of about 2,143,617 (291)

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

INAPPROPRIATE LEFT VENTRICULAR MASS, IN CHILDREN WITH PREDYALITIC CHRONIC RENAL INSUFFICIENCY [PDF]

, 2008
Background: Increased left ventricular (LV) mass in children with chronic renal insufficiency (CRI) might represent an adaptive mechanism to compensate for increased workload.
Romano, Carmela
core   +1 more source

Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction [PDF]

, 2011
<p><b>Background:</b> The purpose of this study was to examine the prevalence of abnormalities in cardiac structure and function present in patients with heart failure and a preserved ejection fraction (HFPEF) and to determine whether ...
Michel Komajda, Baicu, C.F., John S. Gottdiener, Massie, B.M., Zile, M.R., Robert McKelvie, Scott J. Hetzel, Michael R. Zile, John J. McMurray, Catalin F. Baicu, McMurray, J.J., Barry M. Massie, McKelvie, R., Gottdiener, J.S., Hetzel, S.J., Komajda, M., McMurray, J.J.V., Carson, P.E., Peter E. Carson   +18 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

N-terminal proBrain Natriuretic Peptide as Indicator of Left Ventricle Hypertrophy In Hypertensive Patients Compared with Left Ventricle Mass Index in Echocardiography

Majalah Kardiologi Indonesia, 2013
Background: Some research reports the usefulness of the N-terminal proBrain natriuretic peptide (NT proBNP) as a diagnostic tool for left ven-tricular hypertrophy due to increased levels of NT proBNP in hypertensive patients with left ventricular ...
Mohammad Ariful Munir, Djanggan Sargowo
doaj   +1 more source

Left ventricular hypertrophy in renal failure [PDF]

Kidney International, 1998
In patients with terminal renal failure, left ventricular hypertrophy (LVH) is extremely common. It is found in approximately 60 to 80% of patients starting renal replacement therapy. The main causes of LVH are increased preload from hypervolemia and increased afterload from increased peripheral resistance, giving rise to a mixture of eccentric and ...
Amann, Kerstin, Rychlík, Ivan, Miltenberger-Milteny, Gabriel, Ritz, Eberhard   +3 more
openaire   +2 more sources

Quantitative analysis of cardiac left ventricular variables obtained by MRI at 3 T : a pre- and post-contrast comparison [PDF]

, 2012
Short-axis cine images are acquired during cardiac MRI in order to determine variables of cardiac left ventricular (LV) function such as ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and LV mass.
Crowe, E. A., J G Houston, Houston, J. G., Lerski, R. A., R S Nicholas, S Matthew, S J Gandy, Gandy, S. J., Nicholas, R. S., Dunn, M. H., R A Lerski, E A Crowe, Waugh, S. A., S A Waugh, Matthew, S., M H Dunn   +15 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Left Ventricular Hypertrophy [PDF]

Circulation, 2000
When the heart faces a hemodynamic burden, it can do the following to compensate: (1) use the Frank-Starling mechanism to increase crossbridge formation; (2) augment muscle mass to bear the extra load; and (3) recruit neurohormonal mechanisms to increase contractility.
B H, Lorell, B A, Carabello
openaire   +2 more sources

The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging [PDF]

, 2015
peer reviewedThe term 'athlete's heart' refers to a clinical picture characterized by a slow heart rate and enlargement of the heart. A multi-modality imaging approach to the athlete's heart aims to differentiate physiological changes due to intensive ...
Galderisi, Maurizio, Popescu, Bogdan A., Cosyns, B, Petersen, SE, Cardim, Nuno, DAVIN, Laurent, Schroeder, S, Kitsiou, Anastasia, Cosyns, Bernard, Lancellotti, Patrizio, Petersen, Steffen E., Habib, G, Kitsiou, A, Edvardsen, T, Davin, L, Cardim, N, Bruder, Oliver, Popescu, Bogdan Alexandru, Burgstahler, C, D'Andrea, Antonello, Donal, E, Bruder, O, Plein, S, Freitas, A, Freitas, Antonio, Burgstahler, Christof, Galderisi, M, Edvardsen, Thor, Donal, Erwan, Lancellotti, P, Plein, Sven, D'Andrea, A, Schroeder, Stephen, Habib, Gilbert, Popescu, BA   +34 more
core   +1 more source