Results 51 to 60 of about 2,143,617 (291)

LEFT VENTRICULAR HYPERTROPHY; HAEMODIALYSIS PATIENTS

The Professional Medical Journal, 2015
Cardiovascular system diseases are playing the outstanding role in the cause ofmorbidity and mortality in dialysis patients. Left ventricular hypertrophy is one of the universalstructural abnormalities in patients on regular dialysis. Objective: The target of the study wasto search out the frequency of left ventricular hypertrophy in end stage renal ...
Bhagwan Das, Rafique Ansari, Santosh Kumar, Shafique-ur-Rehman Memon   +3 more
openaire   +2 more sources

Clinical and Echocardiographic Findings of Left Ventricular Diastolic Dysfunction Among Hypertensive Patients at Muhimbili National Hospital, Dar es Salaam [PDF]

, 2012
Hypertension is the commonest of the cardiovascular risk factors, whose prevalence in Tanzania is high between 20-30%, among rural and urban residents respectively.
Sanga, T.S, Sanga, Tulizo Shemu
core  

Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities? [PDF]

, 2011
Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the ...
Sanjay K Prasad, Papadakis, M, Sharma Sanjay, Prasad, Sanjay K., Chandra, N, Prasad, SK, O'Hanlon, Rory, O'Hanlon Rory, Papadakis, Michael, O'Hanlon, R, Chandra, Navin, Prasad Sanjay K, Michael Papadakis, Sharma, Sanjay, Chandra Navin, Papadakis Michael, Rory O'Hanlon, Wilson, MG, Wilson, Mathew G., Wilson Mathew G, Sanjay Sharma, Sharma, S, Mathew G Wilson, Navin Chandra   +23 more
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension

Antioxidants, 2021
The aim of the study was to assess the relationship between serum selenium and zinc concentrations (Se-S and Zn-S) and the left ventricle geometry in patients suffering from arterial hypertension. A total of 78 people with arterial hypertension (mean age:
Paweł Gać, Karolina Czerwińska, Małgorzata Poręba, Adam Prokopowicz, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba   +6 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

The effect of Valsalva maneuver on diastolic filling indices in patients with essential hypertension.

مجلة كلية الطب, 2010
Background: Left ventricular hypertrophy and diastolic dysfunction are considered to be an important risk factor for cardiovascular morbidity and mortality in asymptomatic hypertensive patients.
Salam A. Mahdi, Najeeb H. Mohammed, Hilal B. AL-Saffar   +2 more
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source