Results 121 to 130 of about 760,497 (383)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Novel individualized power training protocol preserves physical function in adult and older mice [PDF]

, 2019
Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty, functional decline, and reduced quality of life in older adults. Exercise is a recognized therapy for sarcopenia and muscle dysfunction, though not a cure. Muscle power
Fandrey, Katie R., Graber, Ted G., Thompson, LaDora V.   +2 more
core   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

Echocardiographic phenotyping of the continuum of myocardial functional remodelling in left ventricular hypertrophy - machine learning validated with cardiac magnetic resonance [PDF]

, 2021
Filip Lončarić, Pablo-Miki Martí Castellote, L Sanchiz, Gemma Piella, Ana García‐Álvarez, Marta Sitges, Bart Bijnens   +6 more
openalex   +1 more source

Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]

, 2014
Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro, Diaz, Alejandro, Ennis, Irene Lucia, Escudero, Eduardo Manuel, Orlowski, Alejandro, Pinilla, Oscar Andres   +5 more
core   +2 more sources

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test

Italian Journal of Animal Science
Among the Italian autochthonous beef cattle breeds, Marchigiana is particularly important in terms of census and production. In this breed, a SNP inactivating the myostatin gene leads to muscular hypertrophy in the individuals homozygous for the mutated ...
Daniele Colombi, Francesco Perini, Fiorella Sbarra, Andrea Quaglia, Lakamy Sylla, Maria Gracia Luigi-Sierra, Marcel Amills, Emiliano Lasagna   +7 more
doaj   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

JCI Insight, 2019
The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of rapamycin-mediated (mTOR-mediated) podocyte hypertrophy is recognized as an important ...
Victor G. Puelles, J. W. van der Wolde, Nicola Wanner, M. Scheppach, L. Cullen-McEwen, Tillmann Bork, M. Lindenmeyer, Lukas Gernhold, M. N. Wong, Fabian Braun, C. Cohen, M. Kett, C. Kuppe, R. Kramann, Turgay Saritas, C. V. van Roeyen, M. Moeller, L. Tribolet, R. Rebello, Y. B. Sun, Jinhua Li, G. Müller-Newen, M. Hughson, W. Hoy, F. Person, T. Wiech, S. Ricardo, P. Kerr, K. Denton, L. Furic, T. Huber, D. Nikolic-Paterson, J. Bertram   +32 more
semanticscholar   +1 more source

The effect of complex training on horizontal power production in rugby union players : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science at Massey University [PDF]

, 2004
The use of strength and power training regimes is common place among elite and recreational athletes. However, the application of such methods as direct determinants of improvement in sporting performance is a controversial and much debated topic because
Graham, David Fraser
core