Results 121 to 130 of about 674,192 (414)

Ileal hypertrophy and associated true diverticulum as a cause of colic in a horse [PDF]

open access: yes, 2017
A 4-year-old Thoroughbred gelding underwent an explorative celiotomy for a suspected small intestinal obstruction. During surgery, an impacted diverticulum of the ileum was suspected, necessitating a jejunocaecostomy. The owner opted for euthanasia.
Assenza   +7 more
core   +3 more sources

Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men

open access: yesJournal of applied physiology, 2016
We provide novel evidence of the effect of lifting markedly different (lighter vs. heavier) loads (mass per repetition) during whole-body resistance training on the development of muscle strength and hypertrophy in previously trained persons.
Robert W Morton   +8 more
semanticscholar   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

open access: yesAdvanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li   +21 more
wiley   +1 more source

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice

open access: yesJournal of Lipid Research, 2011
Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and ...
Yao Zhang   +7 more
doaj  

Superimposed Whole-Body Electrostimulation Augments Strength Adaptations and Type II Myofiber Growth in Soccer Players During a Competitive Season

open access: yesFrontiers in Physiology, 2019
BackgroundThe improvement of strength and athletic performance during a competitive season in elite soccer players is a demanding task for the coach.AimsAs whole-body electrostimulation (WB-EMS) training provides a time efficient stimulation potentially ...
Andre Filipovic   +8 more
doaj   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

open access: yes, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 (mTOR complex 1) activation with the ...
Amy Patton   +12 more
core   +4 more sources

Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure

open access: yesFrontiers in Cardiovascular Medicine, 2019
Endothelial cells are, by number, one of the most abundant cell types in the heart and active players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining cardiac vascularization and perfusion during physiological ...
Rajinikanth Gogiraju   +2 more
semanticscholar   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

MEF2 and the Right Ventricle: From Development to Disease

open access: yesFrontiers in Cardiovascular Medicine, 2019
Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function.
Katharine R. Clapham   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy