Results 161 to 170 of about 674,192 (414)

S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy

Cell Reports, 2016
Loss of skeletal muscle mass and force aggravates age-related sarcopenia and numerous pathologies, such as cancer and diabetes. The AKT-mTORC1 pathway plays a major role in stimulating adult muscle growth; however, the functional role of its downstream ...
Manuela Marabita, Martina Baraldo, Francesca Solagna, Judith Johanna Maria Ceelen, Roberta Sartori, Hendrik Nolte, Ivan Nemazanyy, Stéphane Pyronnet, Marcus Kruger, Mario Pende, Bert Blaauw   +10 more
doaj   +1 more source

Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months [PDF]

, 2011
BackgroundPlantar pressures are commonly used as clinical measures, especially to determine optimum foot orthotic design. In rheumatoid arthritis (RA) high plantar foot pressures have been linked to metatarsophalangeal (MTP) joint radiological erosion ...
A Schmiegel, AE Williams, AE Williams, AL Randolph, Anita Gay, Arthritis and Musculoskeletal Alliance, BJ Ejbjerg, C Giacomozzi, Catherine J Bowen, Christopher J Edwards, CJ Bowen, CJ Bowen, CJ Bowen, CY Li, D Rosenbaum, David Culliford, DE Turner, DE Turner, DE Turner, DE Turner, FC Arnett, G Vidmar, H Hsiao, H Tuna, HM Hulsmans, J Woodburn, JA Singh, James Beacroft, Jane Burridge, JM Farrant, JM Koski, Lindsey Hooper, M Backhaus, M Boers, M van der Leeden, M van der Leeden, ML Prevoo, Nigel K Arden, P Helliwell, PR Fortin, RJ Wakefield, RN Silvester, Ruth Allen, S Naidoo, SJ Otter, SJ Otter   +45 more
core   +3 more sources

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Proceedings of the National Academy of Sciences of the United States of America, 2006
Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of sarcomeres, and reactivation of fetal genes, often culminating ...
E. van Rooij, L. Sutherland, Ning Liu, Andrew H. Williams, John R. McAnally, R. Gerard, J. Richardson, E. Olson   +7 more
semanticscholar   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Combining ECG Criteria for Left Ventricular Hypertrophy Improves Risk Prediction in Patients With Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPatients with hypertension with ECG left ventricular hypertrophy (LVH) have higher cardiovascular morbidity and mortality, but single ECG criteria may underestimate risk.
Peter M. Okin, Darcy A. Hille, Sverre E. Kjeldsen, Richard B. Devereux   +3 more
doaj   +1 more source

EVIDENCE-BASED RESISTANCE TRAINING RECOMMENDATIONS FOR MUSCULAR HYPERTROPHY [PDF]

Objective: There is considerable interest in attaining muscular hypertrophy in recreational gym-goers, bodybuilders, older adults, and persons suffering from immunodeficiency conditions.
Fisher, James, Steele, James
core  

Adiponectin and Cardiac Hypertrophy in Acromegaly [PDF]

, 2016
Background. Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin
Akdag, B, Akin, F, Gurbulak, S, Kaptanoglu, B, Tanriverdi, H, Topsakal, S, Yaylali, GF, Yerlikaya, E   +7 more
core   +2 more sources

A Long Non-Coding RNA Defines an Epigenetic Checkpoint in Cardiac Hypertrophy

Nature Network Boston, 2016
Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated.
Zhihua Wang, Xiao-Jing Zhang, Yan‐Xiao Ji, Peng Zhang, Ke-Qiong Deng, Jun Gong, Shuxun Ren, Xinghua Wang, Iris Chen, He Wang, Chen Gao, Tomohiro Yokota, Yen-Sin Ang, Shen Li, Ashley A. Cass, T. Vondriska, Guangping Li, Arjun Deb, D. Srivastava, Huang-Tian Yang, Xinshu Xiao, Hongliang Li, Yibin Wang   +22 more
semanticscholar   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Cellular basis of differential endochondral growth in Lake Malawi cichlids

Developmental Dynamics, Volume 251, Issue 12, Page 2001-2014, December 2022., 2022
Abstract Background The shape and size of skeletal elements is determined by embryonic patterning mechanisms as well as localized growth and remodeling during post‐embryonic development. Differential growth between endochondral growth plates underlies many aspects of morphological diversity in tetrapods but has not been investigated in ray‐finned ...
Savannah Johnson, Brian Heubel, Carson Bredesen, Thomas Schilling, Pierre Le Pabic   +4 more
wiley   +1 more source