Results 71 to 80 of about 528,761 (298)

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING [PDF]

, 2022
Lulu Yang, Wenchang Xiao, Huan Li, Zhengyang Hao, Gui-Zhi Liu, Dianhong Zhang, Leiming Wu, Zheng Wang, Yanqing Zhang, Zhen Huang, Yanzhou Zhang   +10 more
openalex   +1 more source

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

Nature Communications, 2018
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct cardiomyocyte gene programs encoding ...
S. Nomura, M. Satoh, T. Fujita, Tomoaki Higo, Tomokazu S. Sumida, T. Ko, Toshihiro Yamaguchi, Takashige Tobita, A. Naito, Masamichi Ito, K. Fujita, M. Harada, H. Toko, Yoshio Kobayashi, K. Ito, E. Takimoto, H. Akazawa, H. Morita, H. Aburatani, I. Komuro   +19 more
semanticscholar   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Recent Insights into the Contribution of the Changing Hypertrophic Chondrocyte Phenotype in the Development and Progression of Osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2018
Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and societal burden due to the cost of symptomatic treatment, inability to work, joint replacement, and rehabilitation is huge and increasing.
Ellen G. J. Ripmeester, Ufuk Tan Timur, Marjolein M. J. Caron, Tim J. M. Welting   +3 more
doaj   +1 more source

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

Nature Communications, 2017
Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and
M. M. Reza, Nathiya Subramaniyam, Chu Ming Sim, Xiaojia Ge, Durgalakshmi Sathiakumar, C. McFarlane, Mridula Sharma, R. Kambadur   +7 more
semanticscholar   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice

Physiological Reports
MicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in regulating gene expression post‐transcriptionally. They are involved in various developmental and physiological processes, and their dysregulation is linked to various diseases ...
Shengyi Fei, Blake D. Rule, Joshua S. Godwin, C. Brooks Mobley, Michael D. Roberts, Ferdinand vonWalden, Ivan J. Vechetti   +6 more
doaj   +1 more source

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

Nature Communications, 2018
AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ...
R. Gélinas, Florence Mailleux, J. Dontaine, L. Bultot, B. Demeulder, A. Ginion, E. Daskalopoulos, H. Esfahani, Emilie Dubois-Deruy, B. Lauzier, Chantal Gauthier, Aaron K. Olson, Bertrand Bouchard, Christine Des Rosiers, Benoit Viollet, Kei Sakamoto, J. Balligand, J. Vanoverschelde, Christophe Beauloye, S. Horman, Luc Bertrand   +20 more
semanticscholar   +1 more source