Results 61 to 70 of about 47,286 (245)

Effect Modification of Hyperuricemia, Cardiovascular Risk, and Age on Chronic Kidney Disease in China: A Cross-Sectional Study Based on the China Health and Nutrition Survey Cohort

Frontiers in Cardiovascular Medicine, 2022
IntroductionThe question of whether the increased burden of chronic kidney disease (CKD) is caused by the interaction of hyperuricemia and cardiovascular disease (CVD) risk factors or is accelerated by aging remains unresolved.
Yang Li, Yang Li, Yang Li, Bowen Zhu, Bowen Zhu, Bowen Zhu, Yeqing Xie, Yeqing Xie, Yeqing Xie, Shi Jin, Shi Jin, Shi Jin, Weiran Zhou, Weiran Zhou, Weiran Zhou, Yi Fang, Yi Fang, Yi Fang, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding   +20 more
doaj   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. [PDF]

, 2019
ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was
Baumgartner, Scott, Goldfarb, David S, Jalal, Diana, Pillinger, Michael, Saag, Kenneth G, Schechter, Bruce M, Terkeltaub, Robert, Valiyil, Ritu, White, William B   +8 more
core   +1 more source

Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. [PDF]

, 2012
High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states.
Döring, Angela, Kowall, Bernd, Meisinger, Christa, Rathmann, Wolfgang, Stöckl, Doris, Thorand, Barbara   +5 more
core   +4 more sources

Associations of circulating multiple metals with the risk of incident hyperuricemia and the average annual change in uric acid levels

Ecotoxicology and Environmental Safety, 2023
Background: Hyperuricemia has been linked to exposure to certain metals in cross-sectional studies. However, prospective studies evaluating the associations of multiple metal exposures with incident hyperuricemia are scarce.
Jianjian Xu, Yutong You, Yu Yuan, Hao Wang, Tangchun Wu, Pinpin Long   +5 more
doaj   +1 more source

Hyperuricemia and Cardiovascular Disease

Reviews in Cardiovascular Medicine, 2017
Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research.
Ruochi Zhao, Fuxing Zhang, Dandan Zhang, Wenyuan Zheng, Jinsong Cheng, Zhenyu Xu, Shuangshuang Zhang, Ning Huangfu, Yong Wang   +8 more
openaire   +5 more sources

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

Arthritis &Rheumatology, EarlyView.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Prevalence and Risk Factors of Hyperuricemia in Patients with Chronic Kidney Disease and Non-Alcoholic Fatty Liver

Clinical and Experimental Gastroenterology, 2020
Sima Golmohammadi,1,2 Marjan Tavasoli,1 Nadia Asadi1,2 1Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Internal Medicine, School of Medicine, Kermanshah University of ...
Golmohammadi S, Tavasoli M, Asadi N
doaj  

Prevalence and associated factors of hyperuricemia among Chinese patients with diabetes: a cross-sectional study

Therapeutic Advances in Endocrinology and Metabolism, 2023
Background: As a part of metabolic syndrome, hyperuricemia has a higher incidence in patients with diabetes than in the general population owing to various underlying factors.
Shiyi Sun, Lihong Chen, Dawei Chen, Yan Li, Guanjian Liu, Lin Ma, Jun Li, Fangwei Cao, Xingwu Ran   +8 more
doaj   +1 more source

Integrated In Vitro and In Silico Characterization of 5‐Hydroxyferulic Acid: Antioxidant, Anti‐Inflammatory, Anti‐Hemolytic, and Cytotoxic Potential

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the pursuit of novel antioxidant and anti‐inflammatory agents, we investigated 5‐hydroxyferulic acid (5‐OHFA), a hydroxylated derivative of the well‐known phenolic compound ferulic acid (FA). This study aimed to determine whether structural modification enhances the biological activity of FA.
Syrine Sakouhi, Sonia Ben Younes, Fatma Arrari, Afef Nahdi, Jalloul Bouajila, Abada Mhamdi   +5 more
wiley   +1 more source