Advancing precision medicine in axial spondyloarthritis: insights from multi-omics approaches
Frontiers in MedicineAxial Spondyloarthritis (axSpA) is a chronic inflammatory disease influenced by genetic, immune, metabolic, and environmental factors, significantly impacting patients’ quality of life.
Yuanpiao Ni +8 more
doaj +1 more source
F1000Research, 2021 Background: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia.
Juan Manuel Vargas-Morales +5 more
doaj +1 more source
The Influence of Low Purine Diet and Physical Activity on Changing of Uric Acid Levels in Hyperuricemia [PDF]
, 2017 Hyperuricemia is caused by elevated levels of uric acid in the blood due to excessive production or reduced disposal. Factors that contribute to increased uric acid production are the consumption of foods that contain lots of purine and uric acid ...
Dewantari, N. M. (Ni) +1 more
core +1 more source
Risk Factors in the Incidence of Gouty Arthritis in Masohi Town, Central Maluku Regency in 2010 [PDF]
, 2012 The gouty arthritis incidence rate in Masohi Townof Central Maluku Regency is 54 people based on the data from the general hospital in Masohi. The aim of study was to find out the risk factor in the incidence of gouty arthritis in Masohi Town of ...
Amiruddin, R. (Ridwan) +2 more
core +1 more source
Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA
Nature CommunicationsHyperuricemia is associated with an increased risk of gout, hypertension, diabetes, and cardiovascular diseases. Most mammals maintain normal serum uric acid (SUA) via urate oxidase (Uox), an enzyme that metabolizes poorly-soluble UA to highly-soluble ...
Mengjie Zhang +13 more
semanticscholar +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources
Gut microbes, 2022 Hyperuricemia is the second most prevalent metabolic disease to human health after diabetes. Only a few clinical drugs are available, and most of them have serious side effects.
R. Zhao +7 more
semanticscholar +1 more source
Patients Prescribed Anakinra for Acute Gout Have Baseline Increased Burden of Hyperuricemia, Tophi, and Comorbidities, and Ultimate All-Cause Mortality. [PDF]
, 2019 Objective:The interleukin-1 (IL-1) receptor antagonist anakinra is an effective, off-label option in acute gout flares, when conventional therapy options are narrowed.
Pedersen, Brian +2 more
core
Treatment with Allopurinol is Associated with Lower Risk of Acute Kidney Injury in Patients with Gout: A Retrospective Analysis of a Nested Cohort [PDF]
, 2017 Gout is characterized by recurrent episodes of acute inflammation of joint structures, called gout flares, and flares are commonly treated with nonsteroidal anti-inflammatory drugs (NSAIDs).
Pérez Ruiz, Fernando
core +2 more sources
Dyslipidemia and hyperuricemia: a cross-sectional study of residents in Wuhu, China
BMC Endocrine DisordersBackground While dyslipidemia has been recognized as a potential risk factor for hyperuricemia, there is currently a dearth of large-scale data specifically focused on studying the relationship between these two conditions.
Yicheng Fang +10 more
semanticscholar +1 more source