Results 21 to 30 of about 320 (90)

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, Volume 6, Issue 2, Page 71-82, June 2026.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, Volume 67, Issue 6, Page 487-491, June 2026.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Detection of renal tubular transporter proteins in canine urinary extracellular vesicles using liquid chromatography–tandem mass spectrometry

Veterinary Clinical Pathology, Volume 55, Issue 2, Page 172-177, June 2026.
Abstract Urinary extracellular vesicles (UEVs) are membranous particles that carry renal tubular transporter proteins. Here, we evaluate whether selected renal tubular transporter proteins can be detected in UEVs isolated from small volume (1–5 mL) canine urine samples of healthy dogs and canine patients with elevated circulating parathyroid hormone ...
L. J. McGravey, P. R. Antrobus, T. L. Williams   +2 more
wiley   +1 more source

A Case of Congenital Hypothyroidism in Cats: Diagnostic Challenges and Therapeutic Outcomes

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Congenital hypothyroidism in a 3‐year‐old Persian cat was diagnosed via low total thyroxine levels unresponsive to TSH stimulation, alongside clinical signs of dwarfism and renal failure. Levothyroxine therapy significantly improved renal function and activity within 1 week.
Morteza Ezati Kakalar, Farkhondeh Fahim Dezhban, Amin Zamani, Sina Sabour Razlighi   +3 more
wiley   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 2, Page 236-246, April 2026.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Presentation and Management of Addison's Disease in a 10‐Year‐Old Boy: A Case Report

iLABMED, Volume 4, Issue 1, Page 59-63, March 2026.
ABSTRACT Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder characterized by impaired adrenal hormone production. We report a case of a 10‐year‐old boy with congenital adrenal hyperplasia and secondary Addison's disease on long‐term corticosteroid therapy who presented with recurrent non‐bilious vomiting, low‐grade fever,
Srinivasan Sivannan, Mohammed Azhar Hussain, Syed Mohammed Hussaini, Pasumarthi Tejashree, Karthikeyan Elumalai   +4 more
wiley   +1 more source

Efficacy and Safety of DNV3 (a Lymphocyte‐activation Gene 3–blocking Antibody) Combined With Toripalimab and Chemotherapy in Advanced Melanoma: An Open‐label, Single‐arm Clinical Trial

MedComm, Volume 7, Issue 3, March 2026.
This investigator‐initiated trial demonstrates that LAG‐3/PD‐1 dual blockade (DNV3 + toripalimab) combined with chemotherapy achieves a 44.4% overall response rate (ORR) in advanced melanoma, showing particular efficacy in anti‐PD‐(L)1‐resistant patients (42.9% ORR, 7.36‐month median PFS), treatment‐naïve mucosal melanoma (50.0% ORR), and those with ...
Jing Lin, Lizhu Chen, Ling Chen, Dingyi Wang, Yuping Lu, Huishan Zhang, Ping Chen, Wei Yan, Zuoxiang Xiao, Yu Chen   +9 more
wiley   +1 more source

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley   +1 more source

Acute collapse in a dog with multiple autoimmune syndromes and polymyositis complicated by suspected organophosphate/carbamate toxicity

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6.5‐year‐old, spayed, female dog presented in acute respiratory distress. On admission, the dog exhibited dyspnoea, bradycardia, cyanosis and gastrointestinal signs, requiring immediate intubation and mechanical ventilation. Diagnostic evaluation revealed reduced butyrylcholinesterase activity, non‐cardiogenic pulmonary oedema, elevated ...
Sarah Hefer, Efrat Kelmer, Michal Mazaki Tovi, Dana Peery, Kobi Aharoni, Nir Edry, Sigal Klainbart   +6 more
wiley   +1 more source

Diagnosis of canine spontaneous hypoadrenocorticism. [PDF]

Canine Med Genet, 2022
Guzmán Ramos PJ, Bennaim M, Shiel RE, Mooney CT.   +3 more
europepmc   +1 more source