Results 151 to 160 of about 45,440 (316)

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

The Search for a Hypocalcemic Factor in the Thymus Gland. II. : Improved Method for the Purification of the Substance producing Hypocalcemia in Rabbits

, 1971
Akira Mizutani, Katsuhiko Yamamoto, H Sato, Yasuko Saito, HISASHI KITSUGAWA, Haruko Yamamoto   +5 more
openalex   +2 more sources

Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial

International Journal of Cancer, Volume 156, Issue 11, Page 2178-2187, 1 June 2025.
What's new? Bone metastases are common in a variety of cancer types, causing increased pain and worse outcomes. Suppression of bone turnover, such as with the monoclonal antibody denosumab, results in fewer skeletal complications and improved prognosis. Here, the authors demonstrate the safety and efficacy of a similar antibody, JMT103. Like denosumab,
Ran Ran, Hongtao Li, Tao Sun, Huan Zhou, Aimin Zang, Hongqian Guo, Hua Xie, Shikai Wu, Yong Yan, Xing Yin, Hailin Xiong, Hong Li, Jing Yuan, Juan Wang, Huiping Li, Jin Li   +15 more
wiley   +1 more source

Venetoclax Combined With Chemotherapy in Pediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 72, Issue 6, June 2025.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and although many patients respond to induction therapy, those who relapse or have refractory disease face a poor prognosis. Venetoclax has promising preclinical and clinical activity in ALL.
Andrew E. Place, Seth E. Karol, Christopher J. Forlenza, Todd M. Cooper, Christopher Fraser, Gunnar Cario, Maureen M. O'Brien, Nicolas U. Gerber, Jean‐Pierre Bourquin, Dirk Reinhardt, Jeffrey E. Rubnitz, Joseph T. Opferman, Gauri Sunkersett, Maika Onishi, Diana R. Dunshee, Xin Chen, Kristina Unnebrink, Deeksha Vishwamitra, Fengjiao Dunbar, Mohamed Badawi, Jeremy A. Ross, Mignon L. Loh   +21 more
wiley   +1 more source

Ferric Carboxymaltose (FCM)–Associated Hypophosphatemia (HPP): A Systematic Review

American Journal of Hematology, Volume 100, Issue 5, Page 840-846, May 2025.
ABSTRACT Background Since 2015, ferric carboxymaltose (FCM), an intravenous (IV) iron formulation used for treating iron deficiency anemia (IDA), has been associated with an increasing number of reported hypophosphatemia (HPP) cases. Information on HPP clinical manifestations and incidence has not been reviewed.
Joseph Magagnoli, Kevin Knopf, William J. Hrushesky, Kenneth R. Carson, Charles L. Bennett   +4 more
wiley   +1 more source

Hypocalcemia and Hypoparathyroidism Associated With Critical Illness and Aplastic Anemia

AACE Clinical Case Reports
Background/Objective: Severe hypocalcemia is common in critically ill patients. There are different mechanisms. To our knowledge, there are no data about the acute presentation of hypocalcemia at the time of diagnosis of aplastic anemia (AA).
Tatiana Tselovalnikova, MD, PhD, Kavita Jadhav, MD, FACP, John Foxworth, PharmD, Peminda K. Cabandugama, MD, DABOM, Sophia Galustian, MD, Betty M. Drees, MD, FACP, FACE   +5 more
doaj  

Relationship of Milk Secretion to Hypocalcemia in the Dairy Cow

, 1976
E. Travis Littledike
openalex   +1 more source

Neonatal Cholestasis Progressing to a Multisystem Syndrome With Liver Cirrhosis in Two Siblings With FARSA Deficiency: An Evolving Hepatological Phenotype

JIMD Reports, Volume 66, Issue 3, May 2025.
ABSTRACT Biallelic variants in FARSA or FARSB are associated with reduced cytoplasmic phenylalanyl‐tRNA synthetase (FARS1) activity and underlie a multisystem syndrome characterized by growth limitation, developmental delay, brain calcifications, interstitial lung disease (ILD), and liver involvement.
Y. Aelvoet, P. Verloo, A. Vanlander, S. Vande Velde, S. Van Biervliet, P. De Bruyne, L. Hoste, A. Dheedene, L. Pottie, A. Hoorens, M. Mendes, R. De Bruyne   +11 more
wiley   +1 more source

Liver Lobe Torsion Following an Enterotomy for an Obstructive Foreign Body in a Puppy

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
Liver lobe torsion is rare in canine patients, with more than one lobe affected being even more scarce. Liver lobe torsion of one or more lobes was found as an immediate postoperative complication for an exploratory laparotomy with an enterotomy performed in a juvenile dog.
Elizabeth C. Waskover, Jennifer Truong, Lindsay Phillips   +2 more
wiley   +1 more source