Results 281 to 290 of about 5,015,544 (332)

Rational Design of A Two-photon Ratiometric Fluorescent Probe for Hypochlorous Acid with A Large Stokes Shift.

Analytical Chemistry, 2020
By introducing tetrahydroquinoxaline group as the electron donor to enhance intramolecular charge transfer effect, we deliberately designed a coumarin derivative, TQC-HClO, to serve as a two-photon ratiometric fluorescent probe for imaging hypochlorous ...
Long He, Haiqing Xiong, Benhua Wang, Y. Zhang, Jingpei Wang, Hongyan Zhang, Hai-pu Li, Zhao-guang Yang, Xiangzhi Song   +8 more
semanticscholar   +1 more source

An ESIPT-based colorimetric and fluorescent probe with large Stokes shift for the sensitive detection of hypochlorous acid and its bioimaging in cells

, 2021
Hypochlorous acid (HOCl), with a low physiological concentration, plays a vital role in killing the pathogens and anti-inflammation in the human immune system.
Haixian Ren, Fangjun Huo, C. Yin
semanticscholar   +1 more source

Biomarkers of myeloperoxidase-derived hypochlorous acid

Free Radical Biology and Medicine, 2000
Hypochlorous acid is the major strong oxidant generated by neutrophils. The heme enzyme myeloperoxidase catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride. Although myeloperoxidase has been implicated in the tissue damage that occurs in numerous diseases that involve inflammatory cells, it has proven difficult to ...
Anthony J. Kettle, Christine C. Winterbourn   +1 more
openaire   +3 more sources

Hypochlorous Acid Is a Potent Inhibitor of Acetylcholinesterase

Toxicology and Applied Pharmacology, 2002
The role of hydrogen peroxide and peroxynitrite in the induction of airway hyperreactivity has been well described. Another reactive species which is formed during airway inflammation is hypochlorous acid (HOCl). In the present investigation the effect of HOCl on cholinergic innervation of the airway was investigated.
Aalt Bast, Erik Vegt, Guido R.M.M. Haenen, Gertjan J.M. den Hartog, Wim J.F. van der Vijgh   +4 more
openaire   +3 more sources

Ambroxol Is a Scavenger of Hypochlorous Acid and Monochloramine

Pharmacology, 1994
Experimental studies have suggested that ambroxol, a drug clinically used to enhance pulmonary surfactant production, may also exert some anti-inflammatory effects, though specific mechanisms are not yet fully understood. Thus, potential scavenging properties of ambroxol towards the most toxic neutrophil-arising prooxidants hypochlorous acid and ...
LAPENNA, Domenico, de Gioia S, CIOFANI, Giuliano, CUCCURULLO, Franco   +3 more
openaire   +4 more sources

Chlorogenic Acid as a Natural Scavenger for Hypochlorous Acid

Biochemical and Biophysical Research Communications, 1995
The effect of chlorogenic acid (CGA) on the killing of Escherichia coli by hypochlorous acid (HOCI) was examined. CGA prevented E. coli from bactericidal action of HOCI in a concentration-dependent manner. HOCI reacted rapidly with CGA. By comparison with the one- and two-electron oxidation products produced by peroxidase and phenolase reactions ...
Y. Kono, Hitoshi Shibata, Yoshihiro Sawa, Akane Ueda, Y. Kodama   +4 more
openaire   +3 more sources

Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures

Journal of Cosmetic Dermatology, 2020
Hypochlorous acid (HOCl), a naturally occurring molecule produced by the immune system, is highly active against bacterial, viral, and fungal microorganisms.
M. Gold, A. Andriessen, Ashish C Bhatia, P. Bitter, S. Chilukuri, Joel L Cohen, Chris W. Robb   +6 more
semanticscholar   +1 more source

Dual-Response Ratiometric Electrochemical Microsensor for Effective Simultaneous Monitoring of Hypochlorous Acid and Ascorbic Acid in Human Body Fluids.

Analytical Chemistry, 2020
Redox homeostasis between hypochlorous acid (HClO/ClO-) and ascorbic acid (AA) significantly impacts many physiological and pathological processes. Herein, we report a new electrochemical sensor for the simultaneous determination of HClO and AA in body ...
Hui Dong, Yanli Zhou, Le Zhao, Yuanqiang Hao, Yintang Zhang, B. Ye, Maotian Xu   +6 more
semanticscholar   +1 more source

Hydrogen Bond Enhanced the Aggregation-induced Emission for Visualizing Hypochlorous Acid in Inflammation Model and Hepatocellular Carcinoma Model.

Analytical Chemistry, 2020
As an important reactive oxygen species, hypochlorous acid (HClO) is produced in various physiological processes. The ab-normal rise of HClO level is associated with a large number of inflammatory diseases.
Xiaomin Han, Yufan Ma, Yuzhi Chen, Xuefei Wang, Zhuo Wang   +4 more
semanticscholar   +1 more source

Reaction of γ‐Tocopherol with Hypochlorous Acid

Lipids, 2007
AbstractIn addition to being a very good antioxidant, γ‐tocopherol is also an excellent electrophile trap. This is a study of the reactivity of γ‐tocopherol with hypochlorous acid/hypochlorite, a potential biological foe that is both an oxidant and an electrophile. Aqueous sodium hypochlorite (1.72 mmol; pH 7.4) was stirred with γ‐tocopherol (0.12 mmol)
Quyen Nguyen, Peter T. Southwell-Keely
openaire   +3 more sources