Pharmacogenetics of hypoglycemic agents
Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches ...
Irina Vladimirovna Kononenko+3 more
doaj +3 more sources
Mechanism of Action of the Hypoglycemic Agent Diphenyleneiodonium [PDF]
Abstract The effects of the hypoglycemic agent diphenyleneiodonium have been studied both in vivo and in vitro. In 2-day-old rats, diphenyleneiodonium lowered whole body and blood glucose concentrations. At higher concentrations of the agent (10 µg per g), this was accompanied by increased glucose utilization and accumulation of lactic acid.
Henry A. Lardy+3 more
openaire +3 more sources
Hypoglycemic Coma in a Hemodialysis Patient Receiving Blood Glucose-Lowering Therapy With the Single Agent Teneligliptin [PDF]
Blood glucose management in patients undergoing dialysis is clinically challenging. In this population, most conventional oral hypoglycemic agents are contraindicated, especially from the perspective of pharmacokinetics. Dipeptidyl peptidase-4 inhibitors
Takumi Minezumi+5 more
doaj +2 more sources
Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents
Thiazolidinediones are well known for causing reduction in blood glucose levels. A number of thiazolidinediones have been approved for clinical use in diabetes.
Prasanna A. Datar, Sainath B. Aher
doaj +2 more sources
Cocos Nucifera Endocarp Extract Exhibits Anti-diabetic and Antilipidemic Activities in Diabetic Rat Model [PDF]
Background and aim: The fruits of Cocos nucifera have long been used in traditional medicine as anti-inflammatory, antimicrobial, antiparasitic, anticancer, and cardiotonic.
Farjana Akter+5 more
doaj +1 more source
Adulteration of hypoglycemic products: the silent threat [PDF]
Background. The growing tendency toward the adulteration of hypoglycemic products in the market to increase the seller’s profits, the increased promotions of such products by unscrupulous promoters, and the higher rate of consumption by diabetic patients
Raniah I. Alnaser+2 more
doaj +1 more source
Blood glucose, antidiabetic drugs, and risk of stroke [PDF]
Diabetes mellitus is a well-established risk factor for stroke. Among people without baseline diabetes or cardiovascular disease, a low fasting glucose level of < 70 mg/dL is associated with an increased risk of stroke.
Meng Lee, Bruce Ovbiagele
doaj +1 more source
Hypoglycemic agents and incidence of pancreatic cancer in diabetic patients: a meta-analysis
Background and aims: Hypoglycemic agents are the primary therapeutic approach for the treatment of diabetes and have been postulated to impact pancreatic cancer (PC) incidence in diabetic patients.
Zimo Zhao, Xinyi He, Yan Sun
doaj +1 more source
Blockchain associated machine learning and IoT based hypoglycemia detection system with auto-injection feature [PDF]
Hypoglycemia is an unpleasant phenomenon caused by low blood glucose. The disease can lead a person to death or a high level of body damage. To avoid significant damage, patients need sugar. The research aims at implementing an automatic system to detect hypoglycemia and perform automatic sugar injections to save a life.
arxiv +1 more source
Introduction Hypoglycemia is listed as an adverse effect in the package inserts of not only hypoglycemic agents but also many other drugs. We aimed to clarify real-world factors related to an increased risk of hypoglycemia-related hospitalization (HRH ...
Takeshi Horii, Mai Otsuka, Takeo Yasu
doaj +1 more source