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Congenital Hypogonadotrophic Hypogonadism: Minipuberty and the Case for Neonatal Diagnosis [PDF]

Frontiers in Endocrinology, 2019
Congenital hypogonadotrophic hypogonadism (CHH) is a rare but important etiology of pubertal failure and infertility, resulting from impaired gonadotrophin-releasing hormone secretion or action.
Du Soon Swee, Du Soon Swee, Richard Quinton, Richard Quinton   +3 more
doaj   +8 more sources

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism [PDF]

Frontiers in Endocrinology, 2023
IntroductionDelayed puberty (DP) is a frequent concern for adolescents. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic ...
Yuri Aung, Yuri Aung, Vasilis Kokotsis, Kyla Ng Yin, Kausik Banerjee, Gary Butler, Gary Butler, Mehul T. Dattani, Mehul T. Dattani, Mehul T. Dattani, Paul Dimitri, Leo Dunkel, Claire Hughes, Michael McGuigan, Márta Korbonits, Márta Korbonits, George Paltoglou, Sophia Sakka, Pratik Shah, Pratik Shah, Helen L. Storr, Helen L. Storr, Ruben H. Willemsen, Sasha R. Howard, Sasha R. Howard   +24 more
doaj   +9 more sources

Congenital hypogonadotrophic hypogonadism, induction of minipuberty, and future fertility [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2023
A 33-year-old man with Kallmann syndrome had received pulsatile GnRH as an infant for the treatment of cryptorchidism. As an adult, his treatment for fertility with gonadotrophins was unusually rapid compared with expectations, with a total sperm count ...
Bronwyn G A Stuckey, James D Nolan, David M Hurley, Graeme B Martin   +3 more
doaj   +5 more sources

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men [PDF]

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +5 more sources

Normosmic idiopathic hypogonadotrophic hypogonadism due to a rare KISS1R gene mutation [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Hypogonadotrophic hypogonadism is due to impaired or reduced gonadotrophin secretion from the pituitary gland. In the absence of any anatomical or functional lesions of the pituitary or hypothalamic gland, the hypogonadotrophic hypogonadism is referred ...
N Chelaghma, S O Oyibo, J Rajkanna
doaj   +5 more sources

6626 Fertility considerations in Klinefelter Syndrome complicated by hypogonadotrophic hypogonadism [PDF]

J Endocr Soc
Disclosure: M. Govinna: None. S. Sarlos: None. C.A. Allan: None. R. Giri: None. Background: Klinefelter syndrome (KS) remains underdiagnosed with less than 50% of men ever diagnosed and >90% of diagnoses only occurring when fertility is sought. MicroTESE
Mauli Govinna, Stella Sarlos, Carolyn A Allan, Rinky Giri   +3 more
europepmc   +6 more sources

Case Report: A Novel Point Mutation of SOX3 in a Subject With Growth Hormone Deficiency, Hypogonadotrophic Hypogonadism, and Borderline Intellectual Disability [PDF]

Frontiers in Endocrinology, 2022
SOX3 is critical for the development of the pituitary, brain, and face, and SOX3 mutations may lead to hypopituitarism, intellectual disability, and craniofacial abnormalities.
Jing Li, Yuxia Zhong, Tao Guo, Tao Guo, Yerong Yu, Jianwei Li   +5 more
doaj   +3 more sources

Managing congenital hypogonadotrophic hypogonadism: a contemporary approach directed at optimizing fertility and long-term outcomes in males [PDF]

Therapeutic Advances in Endocrinology and Metabolism, 2019
Hormonal induction of spermatogenesis offers men with azoospermia due to hypogonadotrophic hypogonadism (HH) the promising prospect of fertility restoration.
Du Soon Swee, Richard Quinton
doaj   +3 more sources

Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism [PDF]

Brazilian Journal of Otorhinolaryngology, 2018
Introduction: Idiopathic hypogonadotrophic hypogonadism with an olfactory deficit is defined as Kallmann syndrome and is distinct from normosmic idiopathic hypogonadotrophic hypogonadism.
Murat Salihoglu, Onuralp Kurt, Seyid Ahmet Ay, Kamil Baskoy, Aytug Altundag, Muzaffer Saglam, Ferhat Deniz, Hakan Tekeli, Arif Yonem, Thomas Hummel   +9 more
doaj   +3 more sources

Reproductive outcomes in women with hypogonadotrophic hypogonadism, a case series study [PDF]

Middle East Fertility Society Journal, 2021
Background Hypogonadotropic hypogonadism (HH) is a rare condition in which there is gonadal hypofunction due to absence of gonadotropin drive. In this condition, there are very low serum levels of gonadotropins.
Ahmed Elsayed Abdelaal, Mohamed Atef Behery, Ahmed Farouk Abdelkawi   +2 more
doaj   +3 more sources