Congenital hypogonadotrophic hypogonadism, induction of minipuberty, and future fertility [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2023 A 33-year-old man with Kallmann syndrome had received pulsatile GnRH as an infant for the treatment of cryptorchidism. As an adult, his treatment for fertility with gonadotrophins was unusually rapid compared with expectations, with a total sperm count ...
Bronwyn G A Stuckey +3 more
doaj +4 more sources
Managing congenital hypogonadotrophic hypogonadism: a contemporary approach directed at optimizing fertility and long-term outcomes in males [PDF]
Therapeutic Advances in Endocrinology and Metabolism, 2019 Hormonal induction of spermatogenesis offers men with azoospermia due to hypogonadotrophic hypogonadism (HH) the promising prospect of fertility restoration.
Du Soon Swee, Richard Quinton
doaj +4 more sources
Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism. [PDF]
PLoS ONE, 2015 Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous peptide precursors, including neuropeptides and hormones involved in appetite control and glucose metabolism.
Suzanne I M Alsters +14 more
doaj +4 more sources
Case Report: A Novel Point Mutation of SOX3 in a Subject With Growth Hormone Deficiency, Hypogonadotrophic Hypogonadism, and Borderline Intellectual Disability [PDF]
Frontiers in Endocrinology, 2022 SOX3 is critical for the development of the pituitary, brain, and face, and SOX3 mutations may lead to hypopituitarism, intellectual disability, and craniofacial abnormalities.
Jing Li +5 more
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Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men [PDF]
Frontiers in Endocrinology, 2022 BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara +30 more
doaj +4 more sources
Congenital Hypogonadotrophic Hypogonadism: Minipuberty and the Case for Neonatal Diagnosis [PDF]
Frontiers in Endocrinology, 2019 Congenital hypogonadotrophic hypogonadism (CHH) is a rare but important etiology of pubertal failure and infertility, resulting from impaired gonadotrophin-releasing hormone secretion or action.
Du Soon Swee +3 more
doaj +4 more sources
Reproductive outcomes in women with hypogonadotrophic hypogonadism, a case series study [PDF]
Middle East Fertility Society Journal, 2021 Background Hypogonadotropic hypogonadism (HH) is a rare condition in which there is gonadal hypofunction due to absence of gonadotropin drive. In this condition, there are very low serum levels of gonadotropins.
Ahmed Elsayed Abdelaal +2 more
doaj +2 more sources
Normosmic idiopathic hypogonadotrophic hypogonadism due to a rare KISS1R gene mutation [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2018 Hypogonadotrophic hypogonadism is due to impaired or reduced gonadotrophin secretion from the pituitary gland. In the absence of any anatomical or functional lesions of the pituitary or hypothalamic gland, the hypogonadotrophic hypogonadism is referred ...
N Chelaghma, S O Oyibo, J Rajkanna
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Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism [PDF]
Frontiers in Endocrinology, 2023 IntroductionDelayed puberty (DP) is a frequent concern for adolescents. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic ...
Yuri Aung +24 more
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Induction of spermatogenesis in hypogonadotrophic hypogonadism [PDF]
Postgraduate Medical Journal, 1978 SummaryA young male who presented with isolated bihormonal gonadotrophin deficiency is described, Basal levels of LH and FSH were low and there was no response to clomiphene citrate or LHRH. The remaining anterior pituitary function was intact. The administration of a combination of human menopausal gonadotrophin and human chorionic gonadotrophin ...
I M, Spitz +6 more
openaire +4 more sources