First human exposure to FSH-CTP in hypogonadotrophic hypogonadal males [PDF]
This is the first report of human exposure to the novel compound follicle stimulating hormone (FSH)-C-terminal peptide (CTP) 'FSH-CTP' (Org 36286), a long-acting recombinant FSH like substance, consisting of the alpha-subunit of human FSH and a hybrid beta-subunit. The latter is composed of the beta-subunit of human FSH and the C-terminus part (CTP) of
Gerrit Voortman+8 more
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HKCOG guidelines: induction of ovulation [PDF]
This guideline by The Hong Kong College of Obstetricians and Gynaecologists (HKCOG) covers the classification of ovulation disorders, treatment options of various ovulation disorders, and their associated risks ...
Lee, VCY, Li, RHW, Ng, EHY, Yeung, TWY
core
Type 2 Diabetes and Testosterone Therapy
A third of men with type 2 diabetes (T2DM) have hypogonadotrophic hypogonadism (HH) and associated increased risk of cardiovascular and all-cause mortality. Men with HH are at increased risk of developing incident T2DM.
Geoffrey Hackett
doaj +1 more source
The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A+1 more
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Testosterone and gonadotropins in infertile men with Sertoli cell only syndrome from Gaza strip [PDF]
Aim: To assess serum testosterone and gonadotropins in Sertoli cell only syndrome patients from Gaza Strip. Methods: Based on testicular biopsy, a cross section of 74 Sertoli cell only syndrome patients were enrolled in the study.
Abu Jamiea, Samar M+4 more
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Genetic studies of congenital upper limb anomalies [PDF]
The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and approaches have been used ...
Laurell, Tobias
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Unsuspected Klinefelter syndrome mosaicism presenting as osteoporosis: a case report
Hypogonadism secondary to genetic disorders like Klinefelter syndrome has been described as a cause of male osteoporosis, but the diagnosis is frequently missed or delayed because the clinical features are often subtle or at times normal.
Raj Mithun+5 more
doaj
Male hypogonadism at a tertiary care hospital in Karachi, Pakistan [PDF]
Background: Male hypogonadism is defined as \u27inadequate gonadal function, manifested by deficiency in gametogenesis and/or secretion of gonadal hormones\u27. Signs and symptoms of hypogonadism depend primarily on the age of onset. It can be classified
Asghar, Ali+3 more
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Giganto-acromegaly with Hypogonadotrophic Hypogonadism
Gigantism came from Greek word âGiant'. Pathologically, this condition results from the actions of excessive growth hormone (GH) secretion from the pituitary gland during childhood and adolescent before the closure of epiphyseal growth plates. When the height of an individual is several standard deviations above the mean value for the same age, sex ...
Mirza Azizul Hoque+4 more
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Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A+11 more
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