Results 41 to 50 of about 1,468 (202)

Giganto-acromegaly with Hypogonadotrophic Hypogonadism

Journal of Medicine, 1970
Gigantism came from Greek word ‘Giant'. Pathologically, this condition results from the actions of excessive growth hormone (GH) secretion from the pituitary gland during childhood and adolescent before the closure of epiphyseal growth plates. When the height of an individual is several standard deviations above the mean value for the same age, sex ...
Mirza Azizul Hoque, Md Bakhtiar Azam, Muhammad Tassaduq Khan, M M Hoque, Quazi Deen Mohammad   +4 more
openaire   +2 more sources

Visceral adiposity index and triglyceride/high-density lipoprotein cholesterol ratio in hypogonadism

Archives of Endocrinology and Metabolism, 2017
Background Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and ...
Cem Haymana, Alper Sonmez, Aydogan Aydogdu, Serkan Tapan, Yalcin Basaran, Coskun Meric, Kamil Baskoy, Mustafa Dinc, Mahmut Yazici, Abdullah Taslipinar, Cem Barcin, Mahmut Ilker Yilmaz, Erol Bolu, Omer Azal   +13 more
doaj   +1 more source

Absence of Syndactyly Associated With the Common Apert FGFR2 S252W Mutation: A Clinical Report and Likely Molecular Explanation

American Journal of Medical Genetics Part A, Volume 200, Issue 1, Page 215-222, January 2026.
ABSTRACT Apert syndrome is a recognizable craniofacial condition characterized by craniosynostosis, hypertelorism, exorbitism, midface hypoplasia, and complex symmetrical bony and cutaneous ‘mitten’ syndactyly of all four limbs. Around 98% of affected patients have one of two heterozygous missense variants in the FGFR2 gene, encoding either p ...
Ramy Saad, Claire Lawn, Honor Gartland, Louisa Steel, Caitlin Barns‐Jenkins, Greg James, Eleanor Hay, Andrew O. M. Wilkie, Louise C. Wilson   +8 more
wiley   +1 more source

Three Siblings with Idiopathic Hypogonadotropic Hypogonadism in a Nonconsanguineous Family: A Novel KISS1R/GPR54 Loss-of-Function Mutation

JCRPE, 2019
Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disease caused by defects in the secretion of gonadotropin releasing hormone (GnRH) or the action of GnRH on the pituitary gonadotrophes.
Özlem Nalbantoğlu, Gülçin Arslan, Özge Köprülü, Filiz Hazan, Semra Gürsoy, Behzat Özkan   +5 more
doaj   +1 more source

Premature Adrenarche in Children with Prader-Willi Syndrome Treated with Recombinant Human Growth Hormone Seems to Not Influence the Course of Central Puberty and the Efficacy and Safety of the Therapy

Life, 2020
Puberty in children with Prader-Willi syndrome (PWS) is usually delayed and/or incomplete but in some patients premature/early adrenarche is observed. We assessed the premature adrenarche (PA) in PWS patients during the recombinant human growth hormone ...
Agnieszka Lecka-Ambroziak, Marta Wysocka-Mincewicz, Kamila Marszałek-Dziuba, Agnieszka Rudzka-Kocjan, Mieczysław Szalecki   +4 more
doaj   +1 more source

Imaging Assessment of the Pituitary Gland and Long‐Term Endocrinological Abnormalities in Pediatric Brain Cancer Survivors

Journal of Magnetic Resonance Imaging, Volume 61, Issue 6, Page 2516-2522, June 2025.
Background Pediatric brain cancer survivors often experience hypothalamic–pituitary dysfunction due to cranial irradiation and chemotherapy. While hormone deficiencies have been studied, the changes in pituitary size and shape on long‐term MRI and their relationship to endocrine dysfunction remain under‐explored.
Feras Qawasmi, Maria Segev, Tamer Sobeh, Larisa Gorenstein, Gadi Abebe‐Campino, Chen Hoffmann, Michal Yalon, Dalit Modan‐Moses, Shai Shrot   +8 more
wiley   +1 more source

Neurotrophic Factor-α1/Carboxypeptidase E Functions in Neuroprotection and Alleviates Depression

Frontiers in Molecular Neuroscience, 2022
Depression is a major psychiatric disease affecting all ages and is often co-morbid with neurodegeneration in the elderly. Depression and neurodegeneration are associated with decreased neurotrophic factors.
Lan Xiao, Yoke Peng Loh
doaj   +1 more source

‘Bone Health—Across a Woman's Lifespan’

Clinical Endocrinology, Volume 102, Issue 4, Page 389-402, April 2025.
ABSTRACT Despite a high burden of osteoporosis and minimal trauma fractures worldwide, there is still a treatment gap in timely diagnosis and optimal treatment. There is also a lack of international consensus and guidelines on the management of bone fragility in premenopausal women.
Gabrielle Stokes, Madhuni Herath, Navira Samad, Anne Trinh, Frances Milat   +4 more
wiley   +1 more source

Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy

BMC Endocrine Disorders, 2021
Background Many young adults with Duchenne Muscular Dystrophy (DMD) receive long-term glucocorticoids (GC). GC can cause hypogonadotrophic hypogonadism and adolescents may therefore be candidates for pubertal induction. It is unclear whether men with DMD
Yolanda Alins Sahun, Tim Cheetham, Christopher Boot, Volker Straub, Claire L. Wood   +4 more
doaj   +1 more source

A new mutation for Cantu's syndrome

Journal of Education, Health and Sport, 2022
Introduction: Cantu syndrome is one of the rare genetic syndromes. Formally, there are no diagnostic criteria for Cantu syndrome, but given the characteristic appearance and reproducible features in people with a mutation in the ABCC9 gene, there is a ...
Julia Bargieł, Justyna Cabaj, Agata Tarkowska   +2 more
doaj   +1 more source