Results 51 to 60 of about 3,642 (184)

Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]

, 2019
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C, DiFranco, Marino, Mi, Wentao, Quinonez, Marbella, Wu, Fenfen   +4 more
core   +1 more source

Hyperthyroid hypokalemic periodic paralysis

Pakistan Journal of Medical Sciences, 1969
Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000).
openaire   +2 more sources

Acetazolamide in Hypokalemic Periodic Paralysis

Pediatric Neurology Briefs, 2000
The mechanism of action of acetazolamide in the K-deficient diet rat, an animal model of human hypokalemic periodic paralysis (hypoPP), was investigated at the University of Bari, Italy.
J Gordon Millichap
doaj   +1 more source

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. [PDF]

, 2006
MinK-related peptide 2 (MiRP2) and Kv3.4 subunits assemble in skeletal muscle to create subthreshold, voltage-gated potassium channels. MiRP2 acts on Kv3.4 to shift the voltage dependence of activation, speed recovery from inactivation, suppress ...
Abbott, Geoffrey W, Butler, Margaret H, Goldstein, Steve AN   +2 more
core   +1 more source

Evaluating the efficacy of primary treatment for graves' disease complicated by thyrotoxic periodic paralysis [PDF]

, 2014
Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods.
Chan, AC, Chang, RYK, Lang, BHH, Wong, KP   +3 more
core   +4 more sources

Hypokalemic Quadriparesis as the Initial Presentation of Primary Sjögren's Syndrome With Distal Renal Tubular Acidosis: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary Sjögren's syndrome (PSS) typically presents with sicca symptoms, while renal involvement, such as distal renal tubular acidosis (dRTA), is less common. Hypokalemic paralysis as the initial manifestation of PSS is rare. We report a 52‐year‐old woman who presented with acute flaccid quadriparesis due to severe hypokalemia and normal ...
Sagun Baral, Sushmita Bhattarai, Ajaya Raj Gautam, Prabesh Raghubanshi, Krishna Kc   +4 more
wiley   +1 more source

“Hashitoxicosis” and possible acquired Gitelman syndrome: dual pathology leading to a catastrophic hypokalemic periodic paralysis

Asian Journal of Internal Medicine
Thyrotoxic periodic paralysis (TPP) is more commonly seen in Graves’ disease. But TPP can occur in any condition leading to a hyperthyroid state. It’s important to identify the underlying aetiology of the thyrotoxic state as the management differs with ...
M. S. N. Padmasiri, W. D. A. Patirana, N. Sivalingham, B. Rathypriya, P. T. D. Harischandra   +4 more
doaj   +1 more source

Weakness in the Emergency Department: Hypokalemic Periodic Paralysis Induced By Strenuous Physical Activity

Turkish Journal of Emergency Medicine, 2015
SUMMARY: Hypokalemic periodic paralysis is a rare but serious disorder that is typically caused by a channelopathy. Thyrotoxicosis, heavy exercise, high carbohydrate meal and some drugs can trigger channelopathy in genetically predisposed individuals.
Nurettin Ozgur DOGAN, Nazire AVCU, Elif YAKA, Ali ISIKKENT, Ugur DURMUS   +4 more
doaj   +1 more source

Canalopatias em endocrinologia: achados genéticos recentes e fisiopatologia [PDF]

, 2010
Ion channels serve diverse cellular functions, mainly in cell signal transduction. In endocrine cells, these channels play a major role in hormonal secretion, Ca2+-mediated cell signaling, transepithelial transport, cell motility and growth, volume ...
Chiamolera, Maria Izabel, Dias-da-Silva, Magnus Régios, Fujikawa, Aline M., Kunii, Ilda S., Lindsey, Susan C., Maciel, Rui Monteiro de Barros, Rolim, Ana Luiza R., Soares, Fernando de Almeida   +7 more
core   +2 more sources

STIM1 Reduction Prevents Tubular Aggregate Formation and Compromises Muscle Performance in Ageing Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Ageing is an irreversible process involving the gradual decline of cellular functions in all tissues. In male mice, age‐related loss of muscle force is accompanied by the formation of tubular aggregates, which are honeycomb‐like structures composed of membrane tubules, proteins and Ca2+ deposits. Tubular aggregates are also found in
Laura Pérez‐Guàrdia, Roberto Silva‐Rojas, Jocelyn Laporte, Johann Böhm   +3 more
wiley   +1 more source