Results 191 to 200 of about 1,866 (211)

Adult-type hypolactasia and regulation of lactase expression

Biochimica et Biophysica Acta (BBA) - General Subjects, 2005
A common genetically determined polymorphism in the human population leads to two distinct phenotypes in adults, lactase persistence and adult-type hypolactasia (lactase non-persistence). All healthy newborn children express high levels of lactase and are able to digest large quantities of lactose, the main carbohydrate in milk.
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Strip Test is Reliable in Common Prevalences of Hypolactasia

Scandinavian Journal of Gastroenterology, 1987
The object of this study was to compare the indirect diagnostic methods on the basis of urinary galactose determination in the diagnosis of lactose malabsorption with the actual lactase activities. One hundred and seven patients were studied. The specificity and sensitivity of the strip test were 97%.
M. Isokoski, A. Uusitalo, H Arola, T. Koiwla, M. Jauhiainen, O. Keyriläinen, H. Jokela   +6 more
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Beneficial effects of oral tilactase on patients with hypolactasia

European Journal of Clinical Investigation, 2008
ABSTRACTBackground A lactose‐free diet is commonly prescribed to subjects with hypolactasia. We tested the effectiveness of a single ingestion of tilactase (a β‐d‐galactosidase fromAspergillus oryzae) in adults with hypolactasia, previously assessed by lactose H2‐breath test.Materials and methods After measurement of orocecal transit time (OCTT, by ...
P Portincasa, A Di Ciaula, M Vacca, R Montelli, D Q-H Wang, G Palasciano   +5 more
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Hypolactasia and Lactase Persistence Historical Review and the Terminology

Scandinavian Journal of Gastroenterology, 1994
Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century.
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Quick Test: A New Test for the Diagnosis of Duodenal Hypolactasia

Digestive Diseases and Sciences, 2007
The hydrogen (H2) lactose breath test (BT) is a test commonly used for the diagnosis of hypolactasia. However, its sensitivity is not always good. In the last few years, the new Quick Lactase Test (QLT) has been developed for endoscopic diagnosis of adult-type hypolactasia.
Ojetti, Veronica, La Mura, Rossella, Zocco, Maria Assunta, Cesaro, Paola, De Masi, E, La Mazza, A, Cammarota, Giovanni, Gasbarrini, Giovanni Battista, Gasbarrini, Antonio   +8 more
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Mosaic regulation of lactase in human adult-type hypolactasia

Gastroenterology, 1994
We have previously shown that in the proximal-jejunum of hypolactasic humans, just a few villus enterocytes express lactase protein and activity. In the present study, we compared the distribution of lactase messenger RNA (mRNA), protein, and activity in villus enterocytes in tissues obtained from subjects with persistent high lactase activity and ...
MAIURI L, ROSSI M, RAIA, VALERIA, GARIPOLI V, HUGHES LA, SWALLOW D, NOREN O, SJOSTROM H, AURICCHIO S.   +8 more
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Introducing Genetic Testing for Adult-Type Hypolactasia

Digestion, 2005
Background and Aims: To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. Methods: In total, 166 consecutive patients with gastrointestinal symptoms mimicking hypolactasia admitted to the clinic between March 2002 and ...
Hartmut Schmidt, Johann Ockenga, Juliane Jurga, Thomas Fiedler, Winfried A. Voderholzer, Margitta Worm, Janine Genschel, Renita Weltrich, Carsten Büning, Eva-Maria Fiedler, Herbert Lochs   +10 more
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Adult‐type hypolactasia and calcium intake in polycystic ovary syndrome

Clinical Endocrinology, 2012
SummaryObjective  Adult‐type hypolactasia (ATH) is related to lower calcium and milk intake, which might be associated with obesity and metabolic disturbances. Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including central obesity.
Thomas R. Pieber, Hans-Jürgen Gruber, Elisabeth Lerchbaum, Albrecht Giuliani, Barbara Obermayer-Pietsch   +4 more
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Identification of a variant associated with adult-type hypolactasia

Nature Genetics, 2002
Adult-type hypolactasia, also known as lactase non-persistence (lactose intolerance), is a common autosomal recessive condition resulting from the physiological decline in activity of the lactase-phlorizin hydrolase (LPH) in intestinal cells after weaning. LPH hydrolyzes lactose into glucose and galactose.
Nabil Sabri, Enattah, Timo, Sahi, Erkki, Savilahti, Joseph D, Terwilliger, Leena, Peltonen, Irma, Järvelä   +5 more
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Improving diagnosis of adult-type hypolactasia in patients with abdominal complaints

Clinical Chemistry and Laboratory Medicine, 2012
Adult-type hypolactasia is caused by genetic lactase non-persistence. It is the most common cause of lactose intolerance, which results in gastrointestinal symptoms after ingestion of dairy products. Currently, lactose intolerance is investigated by the hydrogen breath test (HBT), which is considered the preferred diagnostic test.
Haberkorn, B.C.M., Ermens, A.A.M., Koeken, A., Cobbaert, C.M., Guldener, C. van   +4 more
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