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Biological Evaluation of Chalcones and Analogues as Hypolipidemic Agents
Archiv Der Pharmazie, 2006AbstractIn order to evaluate the anti‐hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays.
Rozangela Curi Pedrosa +2 more
exaly +3 more sources
Journal of Medicinal Chemistry, 1980
More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate.
T, Watanabe +5 more
exaly +3 more sources
More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate.
T, Watanabe +5 more
exaly +3 more sources
Hypolipidemic agents alter hepatic mitochondrial respiration in vitro
Comparative Biochemistry and Physiology C, Comparative Pharmacology and Toxicology, 1995The direct effects of three different classes of structurally diverse hypolipidemic agents on respiration were studied in mitochondria isolated from donor Sprague-Dawley rats. Two classes of peroxisome proliferators (i.e. plasticizers and hypolipidemic hormones and drugs) and one class of peroxisome inhibitors (i.e.
Michael K Mcintosh, M K Mcintosh
exaly +3 more sources
[Peroxisomes and hypolipidemic agents ].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982 Peroxisomes (microbodies) have been localized in the cytoplasm of various cells, mainly the hepatocytes and the renal tubular cells. Various enzymes were found in the granular matrix and sometimes in the nucleus; they were involved in the production and the degradation of hydrogen peroxide, in regulation of the energetic processes of the cell, and in ...
F, Heller, S, Pourbaix
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Novel Euglycemic and Hypolipidemic Agents. 1
Journal of Medicinal Chemistry, 1998A series of [[(heterocyclyl)ethoxy]benzyl]-2,4-thiazolidinediones have been synthesized by the condensation of corresponding aldehyde 1 and 2,4-thiazolidinedione followed by hydrogenation. Both unsaturated thiazolidinedione 2 and its saturated counterpart 3 have shown antihyperglycemic activity.
B B, Lohray +14 more
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Synthesis of Potential Hypolipidemic Agents
Journal of Pharmaceutical Sciences, 1969Derivatives of 2-(p-chlorophenoxy)-2-methylpropionic acid (I) and 2-(p-chlorophenylthio)-2-methylpropionic acid (II) have been synthesized for the purpose of studying their potential hypolipidemic activity.
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Exacerbation of Psoriasis by the Hypolipidemic Agent, Gemfibrozil
Archives of Dermatology, 1988To the Editor.— Elicitation or exacerbation of psoriasis has occurred following administration of the psychopharmacologic agents, 1 β-blockers, 2 nonsteroidal anti-inflammatory agents, 3 antimalarials, 4 isotretinoin, 5 and chlorthalidone. 6 Abel and coworkers 7 have extensively analyzed and discussed the entire subject of drug-induced psoriasis in an
D A, Fisher, P M, Elias, P L, LeBoit
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