Results 231 to 240 of about 3,173,890 (267)

ChemInform Abstract: The Hypolipidemic Agent Probucol. Mechanism of Action, Hypolipidemic Effects and Clinical Investigations

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L. D. Smirnov, V. P. Lupanov, A. A. Lyakishev   +2 more
openaire   +2 more sources

Indole-Based Fibrates as Potential Hypolipidemic and Antiobesity Agents

Journal of Medicinal Chemistry, 2012
Hypolipidemic and antiobesity effects of the newly synthesized indole-based fibrates were evaluated in Triton WR-1339 and high fat diet (HFD)-induced hyperlipidemic rats. Preliminary screening of all the synthesized compounds was done by using an acute model (Triton model), in which compounds 3f and 3l showed significant antidyslipidemic activity ...
Koneni V. Sashidhara, Gitika Bhatia, Bhanu Shankar Singh, Manoj Kumar, A.K. Khanna, Ravi Sonkar   +5 more
openaire   +3 more sources

Investigation of 3,5-isoxazolidinediones as hypolipidemic agents in rodents.

Pharmaceutical research, 1995
A series of 2-benzoyl-4,4-dialkyl-3,5-isoxazolidinediones proved to have potent hypolipidemic activity, lowering both serum cholesterol and triglyceride levels at 10 or 20 mg/kg/day, IP and orally in rodents. 2-(3,4,5-Trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione+ ++ (4) afforded the best hypolipidemic activity lowering normolipidemic CF1 mouse
Dwayne L. Daniels, Hamby ElSourady, Iris H. Hall, Tyrone Woodard, R. Simlot, Manik L. Debnath, Oi T. Wong, Robert A. Izydore   +7 more
openaire   +3 more sources

Novel pyrimidine and 1,3,5-triazine hypolipidemic agents.

Journal of Medicinal Chemistry, 1984
New compounds were synthesized by changing the substituents of a trisubstituted pyrimidine, i.e., [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio] acetic acid, a potent hypolipidemic agent, impaired, however, by a marked hepatomegaly-inducing
G. D'atri, P. Gomarasca, G. Resnati, G. Tronconi, C. Scolastico, C. Sirtori   +5 more
semanticscholar   +1 more source

Novel euglycemic and hypolipidemic agents. 4. Pyridyl- and quinolinyl-containing thiazolidinediones.

Journal of Medicinal Chemistry, 1999
A series of substituted pyridyl- and quinolinyl-containing 2, 4-thiazolidinediones having interesting cyclic amine as a linker have been synthesized. Both unsaturated thiazolidinediones 5 and saturated thiazolidinediones 6 and their various salts were ...
B. Lohray, V. Bhushan, A. S. Reddy, P. B. Rao, N. Reddy, P. Harikishore, N. Haritha, R. K. Vikramadityan, R. Chakrabarti, R. Rajagopalan, K. Katneni   +10 more
semanticscholar   +1 more source

ChemInform Abstract: STUDIES ON HYPOLIPIDEMIC AGENTS PART 2, SYNTHESES AND HYPOLIPIDEMIC ACTIVITIES OF PHENOXYACETYLINOSINE DERIVATIVES

Chemischer Informationsdienst, 1974
AbstractAus (I) erhält man das Ketal (II), das über (III) die Phenoxyacetylinosine (IV) ergibt.
K. Hiraoka, K. Nagao, M. Hirohashi, E. Sakakibara, F. Miyoshi   +4 more
openaire   +2 more sources

Comparative ultrastructural study of rat hepatocytes after treatment with the hypolipidemic agents probucol, clofibrate, and fenofibrate.

Journal of Toxicology and Environmental Health, Part A, 1980
Experimental findings are reported for two similarly conducted studies. One was designed to compared rat liver cell ultrastructure during and after 91 d of dosing with probucol, a hypocholesterolemic agent, and clofibrate, a hypolipidemic drug known to ...
S. Barnard, Joseph A. Molello, William J. Caldwell, J. E. Lebeau   +3 more
semanticscholar   +1 more source

1,3-Benzodioxole-based Fibrate Derivatives as Potential Hypolipidemic and hepatoprotective agents.

Bioorganic & Medicinal Chemistry Letters, 2021
Yundong Xie, Yanhong Xu, Ji-ping Liu, Bin Wang, Yongheng Shi, Wei Wang, Xiaoping Wang, Mengmeng Sun, Xinya Xu, Xiao-li Bian   +9 more
semanticscholar   +1 more source

Micronized Fenofibrate: A New Fibric Acid Hypolipidemic Agent

Annals of Pharmacotherapy, 1999
OBJECTIVE: To review the efficacy and safety of fenofibrate in the management of hyperlipidemias. DATA SOURCES: A MEDLINE search (1974–October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation.
openaire   +3 more sources

Novel antidiabetic and hypolipidemic agents. 5. Hydroxyl versus benzyloxy containing chroman derivatives.

Journal of Medicinal Chemistry, 1999
Several thiazolidinediones having chroman moieties were synthesized and evaluated for their euglycemic and hypolipidemic activities. Some of the analogues having an aminoalkyl group as a linker between the chroman ring and 4-[5-(2,4-dioxo-1, 3 ...
K. Anji Reddy, B. B. Lohray, V. Bhushan, A. S. Reddy, N. Mamidi, P. Papi Reddy, V. Saibaba, N. Jaipal Reddy, A. Suryaprakash, P. Misra, R. Vikramadithyan, R. Rajagopalan   +11 more
semanticscholar   +1 more source