Results 241 to 250 of about 3,173,890 (267)
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Metabolism of the hypolipidemic agent tiadenol in man and in the rat.
Arzneimittel-Forschung, 1986The metabolism of the hypolipidemic agent 1,10-bis(hydroxyethylthio)decane (tiadenol, Eulip) has been studied in vivo in man and in the rat and in vitro in the rat. Following oral administration, in both species tiadenol was completely absorbed, extensively metabolized by the liver and more than 95% of the dose was eliminated in this form via kidneys ...
R. MAFFEI FACINO +2 more
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Nitric Oxide Releasing Morpholine Derivatives as Hypolipidemic and Antioxidant Agents
Journal of Medicinal Chemistry, 2002The synthesis and evaluation of activity of some nitric acid esters of substituted morpholines are presented. All compounds inhibit lipid peroxidation and reduce cholesterol (20-63%) and triglyceride (37-85%) plasma levels. The more potent NO donors 14 and 17 specifically reduce low-density lipoprotein (LDL).
Eleni A. Rekka +3 more
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, 2004
A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure−activity relationship was developed toward PPARα/γ dual agonism. As a result, (2R)-7-{3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy}
H. Koyama +19 more
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A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure−activity relationship was developed toward PPARα/γ dual agonism. As a result, (2R)-7-{3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy}
H. Koyama +19 more
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Terephthalic Acid in Sprague‐Dawley Rats as a Hypolipidemic Agent
Archiv der Pharmazie, 1993AbstractTerephthalic acid at 20 mg/kg/day in lowered serum cholesterol and triglyceride levels in rats. The cholesterol content was lowered in the lipoprotein fractions. The effects of the agents on de novo lipid synthesis showed that similar enzymes were affected in rat liver and small intestinal mucosa cells as when compared to in vitro tissue ...
Iris H. Hall +4 more
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Chapter 17. Progress in Atherosclerosis Therapy: Hypolipidemic Agents
1983Publisher Summary The importance of the lipoprotein transport system to the regulation of plasma lipid levels in human is firmly established. This system is responsible for delivering triglycerides (TG) primarily to adipose and muscle tissues and for continuously shuttling cholesterol between intestine, liver, and extrahepatic tissues.
C. Stanley Rooney, John D. Prugh
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Bioorganic & Medicinal Chemistry Letters, 2016
P. Theodosis-Nobelos +3 more
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P. Theodosis-Nobelos +3 more
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Hypolipidemic agent probucol (mechanisms of action, hypolipidemic effects, and clinical studies). Review [PDF]
Pharmaceutical Chemistry Journal, 1995 V. P. Lupanov +2 more
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1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent
2002The search for potent and efficacious inhibitors of the enzyme HMG-CoA reductase (HMGRI) was the focus of considerable research in the 1980s. Building on the discovery of the fungal metabolite-derived inhibitors, mevastatin, lovastatin, pravastatin and simvastatin, a number of totally synthetic inhibitors were discovered and developed.
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Comparative thermal stability of two similar-structure hypolipidemic agents
Journal of Thermal Analysis and Calorimetry, 2016I. Ledeți +4 more
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Criteria for use of hypolipidemic agents in adults
American Journal of Health-System Pharmacy, 1994E Morales +4 more
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