Results 41 to 50 of about 49,092 (212)

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Hyponatremic encephalopathy: An uncommon presentation associated with dengue shock syndrome: Two case reports

Journal of Pediatric Critical Care, 2021
Hyponatremia of mild-to-moderate degree is commonly seen in dengue infection. Severe hyponatremia with encephalopathy in dengue infection is rarely seen.
Hasmukh Chapsi Gala
doaj   +1 more source

Population pharmacokinetics of levetiracetam in term neonates with hypoxic–ischemic encephalopathy and therapeutic hypothermia: The LEVNEONAT‐1 study

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram, Moreno Ursino, Julie Leger, Emilie Bourrel‐Ponchel, Florence Flamein, Alexandra Chadie, Isabelle Guellec, Sarah Zohar, Vincent Jullien, Géraldine Favrais   +9 more
wiley   +1 more source

Etiology, Clinical Approach, and Therapeutic Consequences of Hyponatremia

Kidney and Dialysis
A perturbation in the water balance rather than any change in salt content is the main cause of hyponatremia, the most frequent electrolyte abnormality, defined as a serum sodium concentration 120 mEq/L) or severe (Na < 120 mEq/L) hyponatremia, and is ...
Goce Spasovski
doaj   +1 more source

Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma

Medicina, 2021
Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and ...
Katharina Jäckle, Friederike Klockner, Daniel Bernd Hoffmann, Paul Jonathan Roch, Maximilian Reinhold, Wolfgang Lehmann, Lukas Weiser   +6 more
doaj   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Improving healthcare value: Optimizing billing and documentation for inpatient addiction consultation services

Journal of Hospital Medicine, EarlyView.
Abstract Patients with substance use disorder (SUD) represent a high‐complexity, high‐cost population on hospital medicine services, yet their admissions are systematically under‐reimbursed due to narrow clinical documentation. Increasingly, hospital‐based addiction consultation service (ACS) clinicians provide dedicated addiction care to medically ...
Philip A. Durney, Nancy McLaughlin, Susan L. Calcaterra   +2 more
wiley   +1 more source

A rare instance of Ogilvie syndrome in a pediatric patient with a complex medical history: A case report

JPGN Reports, EarlyView.
Abstract Acute colonic pseudo‐obstruction or Ogilvie's syndrome is an acute dilatation of the large bowel without an obstructive lesion. Symptoms include abdominal distension, nausea and vomiting, constipation, and occasional dyspnea. The disorder most commonly involves the cecum and right colon and is most frequently seen in male patients above the ...
Kirby Lampe, Victoria Sarata, Aileen Har, Fernando Zapata   +3 more
wiley   +1 more source

Novel variant and enteroendocrine hormone deficiency in a patient with proline and glutamate‐rich protein with a coiled coil domain 1 (PERCC1) associated enteropathy: New diagnostic and therapeutic insights

JPGN Reports, EarlyView.
Abstract Proline and glutamate‐rich protein with a coiled coil domain 1 (PERCC1)‐associated enteropathy is a rare monogenic congenital diarrhea due to defective enteroendocrine cells (EECs). We describe a 6‐year‐old female with intestinal failure since birth.
Teresa Di Chio, Daniela Gattini, Christina Belza, Iram Siddiqui, Bolette Hartmann, Meghan Zoe Benchimol, Shiqi Zhang, Neil E. Warner, Aleixo M. Muise, Yaron Avitzur   +9 more
wiley   +1 more source

Determinants of Early Renal Function Recovery After TIPS in Patients With Portal Hypertension

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal dysfunction frequently occurs in patients with portal hypertension and is linked to unfavorable clinical outcomes. Transjugular intrahepatic portosystemic shunt (TIPS) has the potential to enhance renal perfusion through portal decompression; however, factors predicting early improvement in renal function remain insufficiently defined ...
Meng Jia, Yang Luo, Zhao‐Yang Tan, Xiao‐Ling Zhou, Xi‐You Zhang, Jing‐Ying Sun, Ye Du   +6 more
wiley   +1 more source