Results 41 to 50 of about 12,021 (209)

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Etiology, Clinical Approach, and Therapeutic Consequences of Hyponatremia

Kidney and Dialysis
A perturbation in the water balance rather than any change in salt content is the main cause of hyponatremia, the most frequent electrolyte abnormality, defined as a serum sodium concentration 120 mEq/L) or severe (Na < 120 mEq/L) hyponatremia, and is ...
Goce Spasovski
doaj   +1 more source

Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma

Medicina, 2021
Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and ...
Katharina Jäckle, Friederike Klockner, Daniel Bernd Hoffmann, Paul Jonathan Roch, Maximilian Reinhold, Wolfgang Lehmann, Lukas Weiser   +6 more
doaj   +1 more source

Electrocardiogram Changes in Patients with Hyponatremia: A Retrospective Study [PDF]

Background and Aim: Hyponatremia is defined as a serum sodium level lower than 135 mEq/L. It is the most common clinical electrolyte disorder. Electrolyte disorders are known to affect electrical conduction in the human heart.
Can Hüzmeli, Ufuk İyigün
core   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Hyponatremia is associated with occurrence of atrial fibrillation in outpatients with heart failure and reduced ejection fraction

Hellenic Journal of Cardiology, 2019
Objectives: Hyponatremia and atrial fibrillation (AF) have been established as strong predictors for worse clinical outcomes in patients with heart failure (HF). However, little is known about hyponatremia in relation to the occurrence of AF.
Yuksel Cavusoglu, Hakki Kaya, Selda Eraslan, Mehmet Birhan Yilmaz   +3 more
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Compare Serum VCAM‐1, NSE, Procalcitonin in Predict Sepsis Induced Encephalopathy in Septic Patients

Journal of Clinical Laboratory Analysis, EarlyView.
Serum VCAM‐1 is associated with septic encephalopathy in the first 7 days of sepsis. NSE and procalcitonin were not associated with septic encephalopathy. ABSTRACT Background Sepsis‐associated encephalopathy (SAE) is a common complication of severe sepsis. Increased concentration of Vascular Cell Adhesion Molecule 1 (VCAM‐1) is associated with SAE in a
Chun‐Fu Lin, Cheng‐Hsien Lu, Chih‐Min Su   +2 more
wiley   +1 more source

Improving healthcare value: Optimizing billing and documentation for inpatient addiction consultation services

Journal of Hospital Medicine, EarlyView.
Abstract Patients with substance use disorder (SUD) represent a high‐complexity, high‐cost population on hospital medicine services, yet their admissions are systematically under‐reimbursed due to narrow clinical documentation. Increasingly, hospital‐based addiction consultation service (ACS) clinicians provide dedicated addiction care to medically ...
Philip A. Durney, Nancy McLaughlin, Susan L. Calcaterra   +2 more
wiley   +1 more source