Results 111 to 120 of about 9,342 (275)

Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene

Frontiers in Endocrinology
Introduction Hypophosphatasia (HPP) is an inborn metabolic error caused by mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSALP) and leading to decreased alkaline phosphatase (ALP) activity.
L. Martínez-Heredia, Manuela Muñoz-Torres, R. Sanabria-de la Torre, Ángela Jiménez-Ortas, Francisco Andújar-Vera, T. González-Cejudo, Victoria Contreras-Bolívar, Sheila González-Salvatierra, J. Gómez-Vida, C. García-Fontana, B. García-Fontana   +10 more
semanticscholar   +1 more source

Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment [PDF]

, 2010
Introduction: Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton ...
Beck, Christine, Beer, Meinrad, Gattenlöhner, Stefan, Girschick, Hermann J., Hofmann, Ulrich, Morbach, Henner, Raab, Peter, Stenzel, Martin, Tappe, Dennis   +8 more
core   +2 more sources

Pyrophosphate Regulates Multilineage Differentiation in Stem Cells From Human Exfoliated Deciduous Teeth

Clinical and Experimental Dental Research, Volume 11, Issue 6, December 2025.
ABSTRACT Background To explore the cellular behavior of stem cells derived from human exfoliated deciduous teeth (SHED) in response to inorganic pyrophosphate (PPi). Materials and Methods SHED cells were isolated from the dental pulp tissues of human primary exfoliated teeth.
Ravipha Suwittayarak, Nunthawan Nowwarote, Chatvadee Kornsuthisopon, Waleerat Sukarawan, Brian L. Foster, Hiroshi Egusa, Thanaphum Osathanon   +6 more
wiley   +1 more source

Monoclonal antibody anti-sclerostin for treatment of pelvic insufficiency fractures in adult hypophosphatasia: A case report

Trauma Case Reports
Hypophosphatasia is a rare inherited metabolic disease leading to inhibition of bone and teeth mineralization that can be complicated by multiple insufficiency fractures.
Pierre-Emmanuel Schwab, Alicia Dessain, Joshua Milby   +2 more
doaj   +1 more source

Skeletal mineralization: mechanisms and diseases [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2019
Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up by MVs form hydroxyapatite crystals, which propagate on collagen ...
Toshimi Michigami
doaj   +1 more source

Papillon Lefevre syndrome: bridge between Dermatologist and Dentist [PDF]

, 2010
Papillon-Lefevre syndrome is a rare autosomal recessively inherited condition which shows features common to both dentistry and dermatology. This disease is characterized by palmoplantar hyperkeratosis and severe periodon- titis.
Brar, Rajdeep, Jindal, Sanjeev Kumar, Sheikh, Soheyl, Singla, Anshu   +3 more
core   +1 more source

Raman Spectroscopic Analysis of Molecular Structure and Mechanical Properties of Hypophosphatasia Primary Tooth

Molecules
Mild hypophosphatasia (HPP) can be difficult to distinguish from other bone disorders in the absence of typical symptoms such as the premature loss of primary teeth. Therefore, this study aimed to analyze the crystallinity of hydroxyapatite (HAp) and the
Hayata Imamura, T. Adachi, Wenliang Zhu, Toshiro Yamamoto, N. Kanamura, Hiroaki Onoda, Aki Nakamura-Takahashi, Masataka Kasahara, Masaru Nakada, Hideo Sato, Giuseppe Pezzotti   +10 more
semanticscholar   +1 more source

Condiciones sistémicas asociadas con periodontitis en la infancia y la adolescencia: una revisión de las posibilidades diagnósticas [PDF]

, 2005
El término periodontitis se usa para describir un grupo de enfermedades multifactoriales que llevan a la destrucción progresiva de las estructuras que unen los dientes a los maxilares, el llamado aparato de soporte, que incluye el ligamento periodontal ...
Korostoff, Jonathan, Pinto, Andrés, Sollecito, Thomas P., Stewart, Jeffrey, Sullivan, Kathleen E.   +4 more
core   +1 more source

Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization [PDF]

During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite (HA) seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Ion
CIANCAGLINI, P., MILLÁN, J.L., SIMÃO, A.M.S., YADAV, M.C.   +3 more
core   +1 more source

Spatial polarimetric second harmonic generation evaluation of collagen in a hypophosphatasia mouse model

Biomedical Optics Express
Polarization-resolved second harmonic generation (pSHG) is a label-free method that has been used in a range of tissue types to describe collagen orientation.
Tianyi Zheng, Emily G Pendleton, Ruth P Barrow, Ana Maslesa, Peter A. Kner, Luke Mortensen   +5 more
semanticscholar   +1 more source