Results 91 to 100 of about 24,867 (235)

A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Gayle S. Jameson, Denise J. Roe, Erkut Borazanci, Diana L. Hanna, Caroline G. P. Roberts, Meredith S. Pelster, Richard C. Frank, Angela T. Alistar, Alan M. Miller, J. Erin Wiedmeier‐Nutor, Sandra D. Algaze, Alison R. Zoller, Sarah J. Hallberg, Betsy C. Wertheim, Keehoon Lee, Derek Cridebring, Joshua D. Rabinowitz, Stephen Gately, Jennifer Keppler, Sunil Sharma, Daniel D. Von Hoff, Drew W. Rasco   +21 more
wiley   +1 more source

Effect of Increased Activity on Metabolic Markers in Captive Black Rhinos: A Pilot Study [PDF]

, 2009
Ex situ (captive) black rhinoceros populations exhibit higher rates of disease than free-ranging counterparts. Preliminary data from an ongoing study supports the association between excessive adipose tissue, iron overload, insulin resistance and ...
Bryk, Josephine M.
core  

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575) [PDF]

, 2013
PURPOSE: To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of Notch signaling and
Suzanne Richter, Philippe L. Bedard, Eric Xueyu Chen, Blaise A. Clarke, Ben Tran, Sebastien J. Hotte, Anastasios Stathis, Hal W. Hirte, Albiruni R. A. Razak, Michael Reedijk, Zhuo Chen, Brenda Cohen, Wen-Jiang Zhang, Lisa Wang, S. Percy Ivy, Malcolm J. Moore, Amit M. Oza, Lillian L. Siu, Elaine McWhirter, L Miele, V Bolos, S Jarriault, A Klinakis, P Rizzo, J Dufraine, LK Phng, R Plentz, L Luistro, A Tolcher, J Wu, C Moorsel Van, N Cook, P Carmeliet, EA Eisenhauer, W Zhang, DC Allred, BC Dickson, M Reedijk, JR Strosberg, I Krop, TP Dang, W He   +41 more
core   +3 more sources

A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background Ataxia telangiectasia Rad3‐related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors conducted a phase 1 trial of berzosertib, a selective ATR inhibitor, in combination with definitive ...
Aarti Bhatia, Zhengjia Chen, Yuji Zhang, Justine Yang Bruce, Susanne Arnold, Varinder Kaur, Jonathan W. Riess, Moon Fenton, Barbara Burtness, Nabil F. Saba, Harold Tara, Conor E. Steuer, Dong M. Shin, Garrett Wasp, Thomas H. Davis, Malini Patel, John C. Schmitz, Priyanka Bhateja, Virginia Diavolitsis, Dan P. Zandberg, Darrion L. Mitchell, Brian F. Kiesel, Charles Kunos, Steven D. Gore, Michael Carducci, Jan H. Beumer, Taofeek K. Owonikoko   +26 more
wiley   +1 more source

Consideration of a family case of X-linked hypophosphatemia through the prism of modern diagnostic and treatment methods

Počki
Background. X-linked hypophosphatemia is the most common form of hereditary vitamin D-resistant rickets. Today, there is a late diagnosis, later treatment start and a significant deterioration in the quality of life of patients with X-linked ...
L.I. Vakulenko
doaj   +1 more source

Iatrogenic Persistent Hypophosphatemia In A Simultaneous Liver-Kidney Transplant Recipient

Kidney Research and Clinical Practice, 2012
Hypophosphatemia from renal phosphate wasting during the immediate postoperative kidney transplant period is common and improves with supplementation.
Ekamol Tantisattamo, Satyanarayana Chekuri   +1 more
doaj   +1 more source

A comparison of renal phosphorus regulation in thermally-injured and multiple trauma patients receiving specialized nutrition support [PDF]

, 2001
To compare phosphorus intake and renal phosphorus regulation between thermally injured patients and multiple trauma patients, 40 consecutive critically ill patients, 20 with thermal injury and 20 with multiple trauma, who required enteral tube feeding ...
Brown, Rex O., Dickerson, Roland N., Gervasio, Jane M., Hickerson, William L., Kudsk, Kenneth A., Sherman, Justin J.   +5 more
core   +2 more sources

A Case Series of Hypermucoid Klebsiella pneumoniae Liver Abscess in Caucasian Americans Without Travel History: An Epidemiologic Shift?

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging cause of community‐acquired pyogenic liver abscess (PLA), classically described in East and Southeast Asia. We report two cases of hvKp‐associated PLA in Caucasian women of American origin with no history of international travel, animal exposure, or Asian food consumption. Both patients
Krishna Sai Kiran Sakalabaktula, Sameer Kumar Majety, Sri Ratna Divya Nanduri, Divya Durga, David Kreps, Devi Prasad Botu, Gopichand Muppana   +6 more
wiley   +1 more source

Long-term renal outcome in children with OCRL mutations: retrospective analysis of a large international cohort [PDF]

, 2016
BACKGROUND: Lowe syndrome (LS) and Dent-2 disease (DD2) are disorders associated with mutations in the OCRL gene and characterized by progressive chronic kidney disease (CKD).
Addis, M, Ahn, YH, Anglani, F, Baronio, F, Bockenhauer, D, Bökenkamp, A, Bürger, J, Cheong, HI, Chung, WY, Fonduli, P, Gellermann, J, Gucev, Z, Konrad, M, Kołbuc, M, Krzemień, A, La Manna, A, La Scola, C, Lee, JW, Ludwig, M, Miklaszewska, M, Moczko, J, Niemirska, A, Paglialonga, F, Paripovic, D, Park, SJ, Park, YH, Rogowska-Kalisz, A, Roszak, M, Runowski, D, Rus, R, Said-Conti, V, Sartz, L, Sikora, P, Siteń, G, Stefanidis, CJ, Szczepańska, M, Tasic, V, Wasilewska, A, Zampetoglou, A, Zaniew, M, Załuska-Leśniewska, I, Zurrida, F   +41 more
core   +1 more source

Incidence of adverse events in iron‐deficient pregnant women and surgical patients undergoing intravenous iron treatment with ferric isomaltose or ferric carboxymaltose: A systematic review

Transfusion, EarlyView.
Dominik Heger, Johannes Volkmann, Stephanie Weibel, Johanna Stoevesandt, Veronika Walzer, Peter Kranke, Patrick Meybohm, Stephanie Stangl   +7 more
wiley   +1 more source