Results 41 to 50 of about 19,756 (220)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Redo hypospadias surgery: current and novel techniques

Research and Reports in Urology, 2018
Sanjay B Kulkarni, Omkar Joglekar, Mohammad H Alkandari, Pankaj M Joshi Kulkarni Reconstructive Urology Center, Pune, India Abstract: Failed hypospadias includes patients with multiple attempts at hypospadias surgery. These present as recurrent stricture,
Kulkarni SB, Joglekar O, Alkandari MH, Joshi PM   +3 more
doaj  

Craniofacial anomalies associated with hypospadias. Description of a hospital based population in South America

International Brazilian Journal of Urology
Introduction: Hypospadias is a congenital abnormality of the penis, in which there is incomplete development of the distal urethra. There are numerous reports showing an increase of prevalence of hypospadias.
Nicolas Fernandez, Rebeca Escobar, Ignacio Zarante   +2 more
doaj   +1 more source

Clinical Characteristics of Hypospadias and Its Association with Very Low Birth Weight Infants with Small for Gestational Age [PDF]

Neonatal Medicine
Purpose To investigate the risk factors associated with hypospadias in very low birth weight (VLBW) infants (VLBWIs). Methods We retrospectively analyzed 729 infants born at ≥24 weeks of gestational age and weighing
Seon Nyo Kim, Seung Hyun Kim, Chan Kim, Hanna Kim, Jieun Hwang, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil Chang, Hyeseon Kim   +9 more
doaj   +1 more source

Incidence of penile curvature in various forms of hypospadias [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction. Hypospadias is a congenital anomaly of the penis, characterised by ectopically positioned urethral meatus and associated anomalies (cryptorchidism, inguinal hernia, penile curvature).
Đorđević Miroslav, Stojanović Borko, Stojsavljević Miodrag, Dučić Siniša, Bižić Marta, Majstorović Marko   +5 more
doaj   +1 more source

PLASTIC SURGERY IN HYPOSPADIAS PATIENTS IN SHARIA MAQASHID REVIEW

Jurnal Al-Dustur, 2021
Recently, Indonesia has been shocked by the problem of hypospadias patients from a former athlete who is also a soldier in the Indonesian Armed Forces (TNI), second sergeant (serda) AM.
Fatahilah Fatahillah, Cecep Soleh Kurniawan, Abdurahman Raden Aji Haqqi, Azme Matali   +3 more
doaj   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Langerhans cells in hypospadias: an analysis of Langerin (CD207) and HLA-DR on epidermal sheets and full thickness skin sections

BMC Urology, 2019
Background Hypospadias are among the most common genital malformations. Langerhans Cells (LCs) play a pivotal role in HIV and HPV infection. The migration of LC precursors to skin coincides with the embryonic period of hypospadias development and genetic
Bernhard Haid, Daniela Reider, Felix Nägele, Anne-Françoise Spinoit, Elisabeth Pechriggl, Nikolaus Romani, Helga Fritsch, Josef Oswald   +7 more
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Normozoospermic men in infertile couples: Potential benefit of early medical diagnostic procedures

Andrology, EarlyView.
Abstract Introduction Infertility, defined as the inability to achieve pregnancy despite regular, unprotected sexual intercourse for 1 year, affects approximately 15% of couples. Male factors contribute to 50% of these cases. The necessity of andrological evaluations for male partners of infertile couples with normozoospermia is currently under ...
Simone Bier, Anton Wolff, Michael Zitzmann, Sabine Kliesch   +3 more
wiley   +1 more source