Results 51 to 60 of about 17,428 (209)

Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13

BMC Medical Genomics, 2019
Background Hypospadias risk–associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs).
Zhongzhong Chen, Xiaoling Lin, Yunping Lei, Haitao Chen, Richard H. Finnell, Yaping Wang, Jianfeng Xu, Daru Lu, Hua Xie, Fang Chen   +9 more
doaj   +1 more source

The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency

, 2009
OBJECTIVE. Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found. Steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) is a key regulator of human sex development and an increasing number of SF-1 (NR5A1) mutations are ...
Mazen, I., Achermann, J.C., Rossi, R., Akkurt, I., Köhler, B., Cetindag, C., Biebermann, H., Grüters, A., Lin, L., Hiort, O.   +9 more
core  

Outcome after Hypospadias Repair: Evaluation Using the Hypospadias Objective Penile Evaluation Score

, 2017
Introduction The Hypospadias Objective Penile Evaluation Score (HOPE-Score) is a concise and reproducible way to describe hypospadias severity. We classified boys undergoing primary hypospadias repair to determine the correlation between the
Andrea Koehn, Friedrich-Wilhelm Roehl, Sarah Krull, Hans-Juergen Hass, Hardy Krause, Klaus Mohnike, Anke Rissmann   +6 more
core   +1 more source

Risk Factors for hypospadias in Northwest Russia: A Murmansk County Birth Registry Study.

PLoS ONE, 2019
BackgroundHypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic.
Anton A Kovalenko, Tormod Brenn, Jon Øyvind Odland, Evert Nieboer, Alexandra Krettek, Erik Eik Anda   +5 more
doaj   +1 more source

Craniofacial anomalies associated with hypospadias. Description of a hospital based population in South America

International Brazilian Journal of Urology
Introduction: Hypospadias is a congenital abnormality of the penis, in which there is incomplete development of the distal urethra. There are numerous reports showing an increase of prevalence of hypospadias.
Nicolas Fernandez, Rebeca Escobar, Ignacio Zarante   +2 more
doaj   +1 more source

Langerhans cells in hypospadias: an analysis of Langerin (CD207) and HLA-DR on epidermal sheets and full thickness skin sections

BMC Urology, 2019
Background Hypospadias are among the most common genital malformations. Langerhans Cells (LCs) play a pivotal role in HIV and HPV infection. The migration of LC precursors to skin coincides with the embryonic period of hypospadias development and genetic
Bernhard Haid, Daniela Reider, Felix Nägele, Anne-Françoise Spinoit, Elisabeth Pechriggl, Nikolaus Romani, Helga Fritsch, Josef Oswald   +7 more
doaj   +1 more source

Unusual presentation of female bladder outlet obstruction- female hypospadias with urethral stenosis

Urology Case Reports, 2020
Hypospadias is a rare birth deformity characterised by shortening of urethra with dorsal ectopia of the urethral meatus. The occurrence of hypospadias in female patients is extremely rare.
Gaurav Bavadiya, Chetan shah, Kalyan K. Sarkar, Prithviraj Ghoshal, Himadri Pathak, Kaushik Sarkar   +5 more
doaj   +1 more source

Tubularized Incised Plate Urethroplasty for Proximal Hypospadias

, 2009
Objective To review our experience of using the tubularized incised plate (TIP) urethroplasty (useful in the treatment of distal hypospadias) to treat proximal hypospadias.
陳世乾, Mizuno, Kentaro; Hayashi, Yutaro; Kojima, Yoshiyuki; Tozawa, Keiichi; Sasaki, Shoichi; Kohri, Kenjiro   +1 more
core  

Penile nerve block predicts higher revision surgery rate following distal hypospadias repair when compared with caudal epidural block: A consecutive cohort study

, 2020
Introduction: Recent literature has suggested caudal epidural blocks (CEB) may increase revision surgery rates following hypospadias repair. We sought to investigate this using a large, multi-surgeon series.
McBride, CA, Borzi, P, Patel, B, Ngoo, A
core   +1 more source

Boys born with hypospadias and fetal growth restriction exhibit shorter anogenital distances: a retrospective cross-sectional study

Frontiers in Pediatrics
BackgroundHypospadias is a common congenital urological malformation in males, potentially associated with inadequate prenatal androgen exposure. Anogenital distances (AGDs) are biomarkers of prenatal androgen action, while fetal growth restriction (FGR)
Wenfeng Pan, Min Wu, Yan Chen, Hua Xie, Yichen Huang, Fang Chen   +5 more
doaj   +1 more source