Results 71 to 80 of about 32,475 (265)

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Langerhans cells in hypospadias: an analysis of Langerin (CD207) and HLA-DR on epidermal sheets and full thickness skin sections

BMC Urology, 2019
Background Hypospadias are among the most common genital malformations. Langerhans Cells (LCs) play a pivotal role in HIV and HPV infection. The migration of LC precursors to skin coincides with the embryonic period of hypospadias development and genetic
Bernhard Haid, Daniela Reider, Felix Nägele, Anne-Françoise Spinoit, Elisabeth Pechriggl, Nikolaus Romani, Helga Fritsch, Josef Oswald   +7 more
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Normozoospermic men in infertile couples: Potential benefit of early medical diagnostic procedures

Andrology, EarlyView.
Abstract Introduction Infertility, defined as the inability to achieve pregnancy despite regular, unprotected sexual intercourse for 1 year, affects approximately 15% of couples. Male factors contribute to 50% of these cases. The necessity of andrological evaluations for male partners of infertile couples with normozoospermia is currently under ...
Simone Bier, Anton Wolff, Michael Zitzmann, Sabine Kliesch   +3 more
wiley   +1 more source

Phenotype expansion of variants affecting p38 MAPK signaling in hypospadias patients

Orphanet Journal of Rare Diseases, 2022
Background Hypospadias is a congenital anomaly of the male urogenital system. Genetics factors play an important role in its pathogenesis. To search for potential causal genes/variants for hypospadias, we performed exome sequencing in a pedigree with ...
Defu Lin, Huakang Du, Sen Zhao, Bowen Liu, Hongcheng Song, Guannan Wang, Weiping Zhang, Haiyan Liang, Pei Liu, Chao Liu, Wenwen Han, Zhenwu Li, Yang Yang, Shuofan Chen, Lina Zhao, Xiaoxin Li, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Ning Sun, Nan Wu   +19 more
doaj   +1 more source

The risk factors of Urethrocutaneous fistula after hypospadias surgery in the youth population

BMC Urology, 2018
BackgroundThe current research aims to evaluate the risk factors of urethrocutaneous fistula after hypospadias surgery among the youth in China.MethodsOne hundred twenty hypospadias patients were enrolled in our study.
Xu-jun Sheng, Ding Xu, Yu Wu, Yongjiang Yu, Jian-hua Chen, J. Qi   +5 more
semanticscholar   +1 more source

Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study

Andrology, EarlyView.
Abstract Background Fetal exposure to endocrine‐disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood.
Sidsel Dan Hull, Karin Sørig Hougaard, Gunnar Toft, Kajsa Kirstine Ugelvig Petersen, Esben Meulengracht Flachs, Christian Lindh, Cecilia Høst Ramlau‐Hansen, Lauren A. Wise, Allen Wilcox, Zeyan Liew, Jens Peter Bonde, Sandra Søgaard Tøttenborg   +11 more
wiley   +1 more source

Risk Factors for hypospadias in Northwest Russia: A Murmansk County Birth Registry Study.

PLoS ONE, 2019
BackgroundHypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic.
Anton A Kovalenko, Tormod Brenn, Jon Øyvind Odland, Evert Nieboer, Alexandra Krettek, Erik Eik Anda   +5 more
doaj   +1 more source

Semen quality in patients with testicular cancer is associated with age and with greatly elevated levels of beta human chorionic gonadotropin

Andrology, EarlyView.
Abstract Background Poor semen quality is a well‐known feature in patients with testicular germ cell tumours (GCTs) at the time of diagnosis but the underlying biological reasons are incompletely understood. Objectives This study aimed to identify GCT‐specific clinical factors that are involved with poor semen quality in GCT patients.
Klaus‐Peter Dieckmann, Johanna Hochmuth‐Tisch, Andrea Salzbrunn, Cord Matthies, Kathrein von Kopylow, Marta Godlewska, Christian Wülfing, Uwe Pichlmeier, Armin Soave, Christian Guido Ruf   +9 more
wiley   +1 more source

CYSTOSTOMY DIVERSION REDUCED COMPLICATIONS FOLLOWING HYPOSPADIAS REPAIR: A SYSTEMATIC REVIEW AND META-ANALYSIS

Jurnal Urologi Indonesia
Objective: This study aims to investigate the associations between the use of cystostomy diversion and the incidence of complications following hypospadias repair.
Irfan Wahyudi, Putu Angga Risky Raharja, Gerhard Reinaldi Situmorang, Arry Rodjani   +3 more
doaj   +1 more source