Results 51 to 60 of about 17,882 (210)

Midodrine as a Countermeasure for Post-Spaceflight Orthostatic Hypotension [PDF]

, 2008
One possible mechanism for post-spaceflight orthostatic hypotension, which affects approximately 30% of astronauts after short duration shuttle missions, is inadequate norepinephrine release during upright posture.
Meck, Janice V., Platts, Steven H., Stein, Sydney P., Stenger, Michael B.   +3 more
core   +1 more source

Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium [PDF]

, 2012
Aims: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their ...
Almgren, Peter, Boerwinkle, Eric, Brody, Jennifer Karen, Couper, David, Fedorowski, Artur, Franceschini, Nora, Hedblad, Bo, Hofman, Albert, Larson, Martin G., Levy, Daniel, Liu, Chunyu, Mattace-Raso, Francesco, Melander, Olle, Newton-Cheh, Christopher Holmes, Psaty, Bruce M., Rice, Kenneth M., Rose, Kathryn L., Rotter, Jerome I., Sjögren, Marketa, Uitterlinden, Andre, Verwoert, Germaine C., Wang, Thomas Jue-Fuu, Witteman, Jacqueline   +22 more
core   +3 more sources

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

The Proportion of Orthostatic Hypotension and Its Relationship with HbA1c Levels in Elderly Patients with Diabetes

Acta Medica Indonesiana, 2016
Aim: to obtain information on the proportion of orthostatic hypotension in elderly patients with diabetes and its relationship with HbA1c levels. Methods: this is a cross-sectional study on 350 patients with diabetes mellitus (DM) aged ≥60 years old who ...
Catarina Budyono, Siti Setiati, Dyah Purnamasari, Cleopas M Rumende   +3 more
doaj   +2 more sources

A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson’s disease

npj Parkinson's Disease, 2023
In Parkinson’s disease (PD), cardiovascular dysautonomia accumulates with disease progression, but studies are lacking on the natural history behind each subtype except orthostatic hypotension.
Sang-Won Yoo, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim   +6 more
doaj   +1 more source

Incidence of Orthostatic Hypotension in Schizophrenic Patients Using Antipsychotics at Sambang Lihum Mental Health Hospital, South Kalimantan

Borneo Journal of Pharmacy, 2021
Schizophrenia is a psychiatric disorder that requires antipsychotics therapy. Antipsychotics cause many side effects, including orthostatic hypotension.
Noor Cahaya, Sandra Putri Wijaya, Khoerul Anwar   +2 more
doaj   +1 more source

The synergistic effect of anticholinergic burden and depression on fall risk in older persons

British Journal of Clinical Pharmacology, EarlyView.
Aims Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent.
Raymond Salet, Nathalie van der Velde, Didi Rhebergen, Bob van de Loo, Lotta Seppala, Natasja M. van Schoor, Bruno Stricker, Marieke Henstra   +7 more
wiley   +1 more source

Investigation of in vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension [PDF]

, 2007
We have previously used a continuous four wavelength near infrared spectrometer to measure changes in the cerebral concentrations of oxy- (Δ[HbO2] and deoxy- haemoglobin (Δ[HHb]) during head-up tilt in patients with primary autonomic failure.
Cooper, C.E., Delpy, D.T., Elwell, C.E., Leung, T.S., Smith, M., Tachtsidis, I., Tisdall, M.   +6 more
core  

Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study [PDF]

, 2016
Background: Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive decline and dementia is ...
Hofman, A. (Albert), Ikram, M.K. (Kamran), Koudstaal, P.J. (Peter), Mattace Raso, F.U.S. (Francesco), Wolters, F.J. (Frank)   +4 more
core   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source