Results 51 to 60 of about 78,000 (283)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Sit-up test for assessing impaired blood pressure regulation in community-dwelling older adults: a cross-sectional study

BMC Geriatrics
Background The sit-up test enables safe orthostatic hypotension assessment without using a tilt table in high fall-risk individuals; however, no study has compared blood pressure responses between older adults with and without orthostatic hypotension ...
Kazuaki Oyake, Yoshiharu Yokokawa
doaj   +1 more source

Orthostatic hypotension and survival.

, 2013
In this Kaplan-Meyer curve we wanted to test if persistent orthostatic hypotension affected survival. Concurrent manifestations of autonomic dysfunction (constipation and urinary incontinence) were not taken into consideration. The black line (group 4∶1)
Dag Aarsland (157629), Elisabet Londos (304688), Lennart Minthon (233859), Kajsa Stubendorff (304687)   +3 more
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Vitamin D Deficiency Implications in Orthostatic Hypotension among Diabetic Patients [PDF]

Zagazig University Medical Journal
Background: Orthostasis is more common in people with diabetes, especially the elderly, and vitamin D receptors are present in vascular smooth muscles, endothelium, and cardiac cells, which may influence cardiac as well as motor responses during ...
Ayman Abdel-Hai, Elsayed Elhosiny, Said Gad   +2 more
doaj   +1 more source

Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease [PDF]

Journal of Movement Disorders, 2013
Background and Purpose: Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD ...
Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee   +2 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

The Proportion of Orthostatic Hypotension and Its Relationship with HbA1c Levels in Elderly Patients with Diabetes

Acta Medica Indonesiana, 2016
Aim: to obtain information on the proportion of orthostatic hypotension in elderly patients with diabetes and its relationship with HbA1c levels. Methods: this is a cross-sectional study on 350 patients with diabetes mellitus (DM) aged ≥60 years old who ...
Catarina Budyono, Siti Setiati, Dyah Purnamasari, Cleopas M Rumende   +3 more
doaj   +2 more sources

Persistent unexplained chest pain and dyspnea in a patient with coronary artery disease: a case report

BMC Cardiovascular Disorders, 2020
Background Neurogenic orthostatic hypotension, a sustained decrease in blood pressure upon standing, is caused by autonomic nervous system failure and characterized by an insufficient increase in heart rate needed to maintain blood pressure upon standing.
Sameh K. Mobarek
doaj   +1 more source

Balance parameters in patients with vs. without orthostatic hypotension.

, 2016
Balance parameters in patients with vs. without orthostatic hypotension.
Romulus Timar (737790), Diana Lungeanu (2633632), Cristian Oancea (599791), Codrina Levai (2633629), Bogdan Timar (599792), Laura Gaiță (2633635)   +5 more
core   +1 more source