Results 71 to 80 of about 135,663 (215)

How to handle polypharmacy in heart failure. A clinical consensus statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Linking guideline‐directed medical therapy (GDMT) implementation and appropriate polypharmacy management in heart failure (HF). Polypharmacy can represent a barrier to the proper implementation of life‐prolonging GDMT for HF. A reasonable balance between the optimization of GDMT and avoiding inappropriate polypharmacy is mandatory in the contemporary ...
Davide Stolfo, Massimo Iacoviello, Ovidiu Chioncel, Markus S. Anker, Antoni Bayes‐Genis, Frieder Braunschweig, Antonio Cannata, Seif El Hadidi, Gerasimos Filippatos, Pardeep Jhund, Alexandre Mebazaa, Brenda Moura, Massimo Piepoli, Robin Ray, Arsen D. Ristic, Petar Seferovic, Maggie Simpson, Hadi Skouri, Carlo Gabriele Tocchetti, Sophie Van Linthout, Cristiana Vitale, Maurizio Volterrani, Kalliopi Keramida, Sven Wassmann, Basil S. Lewis, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +27 more
wiley   +1 more source

Heart rate and blood pressure response improve the prediction of orthostatic cardiovascular dysregulation in persons with chronic spinal cord injury

Physiological Reports, 2020
Unstable blood pressure after spinal cord injury (SCI) is not routinely examined but rather predicted by level and completeness of injury (i.e., American Spinal Injury Association Impairment Scale AIS classification).
Siqi Wang, Jill M. Wecht, Bonnie Legg Ditterline, Beatrice Ugiliweneza, Matthew T. Maher, Alexander T. Lombard, Sevda C. Aslan, Alexander V. Ovechkin, Brielle Bethke, Jordan T. H. Gunter, Susan J. Harkema   +10 more
doaj   +1 more source

Evaluation and management of orthostatic headache in hypermobility disorders

Frontiers in Neurology, 2023
Headache is a frequent symptom among patients with hypermobility spectrum disorders. This mini review focuses specifically on a challenging aspect of headache evaluation in all patients, but especially those with hypermobility – the orthostatic headache.
Olga P. Fermo
doaj   +1 more source

Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver [PDF]

, 2019
Delay differential equations (DDEs) are widely used in mathematical modeling to describe physical and biological systems. Delays can impact model dynamics, resulting in oscillatory behavior. In physiological systems, this instability may signify (i) an attempt to return to homeostasis or (ii) system dysfunction.
arxiv   +1 more source

Adaptive Semi-Supervised Inference for Optimal Treatment Decisions with Electronic Medical Record Data [PDF]

arXiv, 2022
A treatment regime is a rule that assigns a treatment to patients based on their covariate information. Recently, estimation of the optimal treatment regime that yields the greatest overall expected clinical outcome of interest has attracted a lot of attention. In this work, we consider estimation of the optimal treatment regime with electronic medical
arxiv  

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson’s disease

npj Parkinson's Disease, 2023
In Parkinson’s disease (PD), cardiovascular dysautonomia accumulates with disease progression, but studies are lacking on the natural history behind each subtype except orthostatic hypotension.
Sang-Won Yoo, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim   +6 more
doaj   +1 more source

The Health Gym: Synthetic Health-Related Datasets for the Development of Reinforcement Learning Algorithms [PDF]

arXiv, 2022
In recent years, the machine learning research community has benefited tremendously from the availability of openly accessible benchmark datasets. Clinical data are usually not openly available due to their highly confidential nature. This has hampered the development of reproducible and generalisable machine learning applications in health care.
arxiv  

Being Prodromal: Current Criteria in the Context of Isolated REM Sleep Behavior Disorder

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Isolated REM sleep behavior disorder (iRBD) indicates an early α‐synucleinopathy with approximately 90% of individuals pheno‐converting to Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal disease definitions (pPD, pDLB, pMSA) have been introduced.
Anja Ophey, Sinah Röttgen, Julia Reichrath, Elke Kalbe, Gereon R. Fink, Michael Sommerauer   +5 more
wiley   +1 more source

Cardiovascular Autonomic Dysfunction Is the Most Common Cause of Syncope in Paced Patients

Frontiers in Cardiovascular Medicine, 2019
Introduction: Syncope and orthostatic intolerance in paced patients constitute a common clinical dilemma. We, thus, aimed to determine the etiology of syncope and/or symptoms of orthostatic intolerance in paced patients.Methods: Among 1,705 patients with
Ekrem Yasa, Ekrem Yasa, Fabrizio Ricci, Fabrizio Ricci, Fabrizio Ricci, Hannes Holm, Hannes Holm, Torbjörn Persson, Olle Melander, Olle Melander, Richard Sutton, Richard Sutton, Artur Fedorowski, Artur Fedorowski, Viktor Hamrefors, Viktor Hamrefors   +15 more
doaj   +1 more source