Results 91 to 100 of about 308,666 (390)
A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]
arXiv, 2022 This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv
The signaling signature of the neurotensin type 1 receptor with endogenous ligands [PDF]
Besserer-Offroy \'E, et al. (2017). Eur J Pharmacol. 805 (2017)
1-13, 2018 The human neurotensin 1 receptor (hNTS1) is a G protein-coupled receptor involved in many physiological functions, including analgesia, hypothermia, and hypotension. To gain a better understanding of which signaling pathways or combination of pathways are linked to NTS1 activation and function, we investigated the ability of activated hNTS1, which was ...
arxiv +1 more source
Drug Design, Development and Therapy, 2022 Wei-dong Jin,1 Jun-qin Mao,2 Jie Liu,2 Gang Liang,2 Chao Jiang,2 Zhi-min Sheng2 1Department of Anesthesiology, Jinhua Maternity and Child Health Care Hospital, Jinhua, People’s Republic of China; 2Department of Anesthesiology, Wenling Maternity and Child
Jin WD +5 more
doaj
Anesthesia and Analgesia, 2019 BACKGROUND: Postoperative delirium is common in critically ill patients, with a reported incidence of 11%–43%, and is associated with significant morbidity and cost. Perioperative hypotension and consequent brain hypoperfusion may contribute.
K. Maheshwari +8 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao +6 more
wiley +1 more source
Automatic lesion analysis for increased efficiency in outcome prediction of traumatic brain injury [PDF]
arXiv, 2022 The accurate prognosis for traumatic brain injury (TBI) patients is difficult yet essential to inform therapy, patient management, and long-term after-care. Patient characteristics such as age, motor and pupil responsiveness, hypoxia and hypotension, and radiological findings on computed tomography (CT), have been identified as important variables for ...
arxiv
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]
Korean Journal of Anesthesiology, 2011 The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg +2 more
doaj +1 more source
Efficient Novelty Detection Methods for Early Warning of Potential Fatal Diseases [PDF]
arXiv, 2022 Fatal diseases, as Critical Health Episodes (CHEs), represent real dangers for patients hospitalized in Intensive Care Units. These episodes can lead to irreversible organ damage and death. Nevertheless, diagnosing them in time would greatly reduce their inconvenience. This study therefore focused on building a highly effective early warning system for
arxiv
Heart India, 2014 Takayasu′s arteritis is a large-vessel vasculitis which is characterized by both stenotic lesions as well as aneurymal lesions. 1 Aneurysmal lesions most commonly occur in the aortic root and arch leading to development of aortic regurgitation. AR is seen in about 24% of cases at the time of presentation.
VK Shameer +3 more
openaire +3 more sources