Results 111 to 120 of about 279,014 (316)

Misdiagnosed spontaneous intracranial hypotension complicated by subdural hematoma following lumbar puncture

, 2014
Nissrine Louhab,1 Nawal Adali,1 Mehdi Laghmari,2 Wafae El Hymer,2 Said Ait Ben Ali,2 Najib Kissani11Neurology Department, 2Neurosurgery Department, University Hospital of Mohammed the VIth, Cadi Ayyad University, Marrakech, MoroccoIntroduction ...
Kissani N, Ait Ben Ali S, Laghmari M, Adali N, El Hymer W, Louhab N   +5 more
core  

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Heat and Dehydration Additively Enhance Cardiovascular Outcomes following Orthostatically-Stressful Calisthenics Exercise

Frontiers in Physiology, 2017
Exercise and exogenous heat each stimulate multiple adaptations, but their roles are not well delineated, and that of the related stressor, dehydration, is largely unknown.
Ashley P. Akerman, Ashley P. Akerman, Samuel J. E. Lucas, Samuel J. E. Lucas, Rajesh Katare, James D. Cotter   +5 more
doaj   +1 more source

Cardiac arrest in a child during a combined general epidural anesthesia procedure [PDF]

, 2005
An increased risk of perioperative cardiac arrest in children, in comparison to adults, has been recognized. A number of factors associated with perioperative cardiac arrest have been identified, including young age, comorbidities, and emergency ...
Soenarjo, Soenarjo, Soemantri,, A, Sidhartani,, M, Siahaan, Edwin MP, Prabakti, Yudhi   +4 more
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High prevalence of orthostatic hypotension in mild dementia [PDF]

, 2009
Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia.
Aarsland, Dag, Nilsen, Dennis W., Tysnes, Ole B, Tysnes, Ole B., Nilsen, Dennis W. T., Rongve, Arvid, Sønnesyn, Hogne, Nore, Sabine, Ballard, Clive, Sonnesyn, Hogne, Nilsen, Dennis W, Aarsland, Dag; id_orcid, Tysnes, Ole-Bjørn   +12 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

The prevalence of hypotension and hypoxaemia in the prehospital setting of traumatic brain injury in Johannesburg, Gauteng

, 2013
Includes abstract.
Stassen, Willem
core  

Postural hypotension

BMJ, 2021
Artaza Gilani, Stephen P Juraschek, Matthew J Belanger, Julie E Vowles, S Goya Wannamethee   +4 more
openaire   +3 more sources

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source