Results 111 to 120 of about 500,404 (395)

Performance of the Hypotension Prediction Index with non-invasive arterial pressure waveforms in non-cardiac surgical patients

Journal of clinical monitoring and computing, 2020
An algorithm derived from machine learning uses the arterial waveform to predict intraoperative hypotension some minutes before episodes, possibly giving clinician’s time to intervene and prevent hypotension.
K. Maheshwari, S. Buddi, Zhongping Jian, J. Settels, Tetsuya Shimada, B. Cohen, D. Sessler, F. Hatib   +7 more
semanticscholar   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adrenal Crisis [PDF]

, 2019
Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients.
Falhammar, Henrik, Rushworth, R Louise, Torpy, David J   +2 more
core   +1 more source

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

, 2016
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial ...
Besecker, Emily Swartz, Cooper, Timothy K., Deiter, Gina M., Holmes, Gregory Michael, Pironi, Nicole   +4 more
core   +1 more source

The significance of non-sustained hypotension in emergency department patients with sepsis [PDF]

, 2009
Objective Few studies have documented the incidence and significance of non-sustained hypotension in emergency department (ED) patients with sepsis. We hypothesized that ED non-sustained hypotension increases risk of in-hospital mortality in patients ...
Jones, Alan E, Kline, Jeffrey A., Marchick, Michael R   +2 more
core   +1 more source

Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study

PLoS ONE, 2020
Objective Hypotension following endotracheal intubation in the ICU is associated with poor outcomes. There is no formal prediction tool to help estimate the onset of this hemodynamic compromise. Our objective was to derive and validate a prediction model
N. Smischney, R. Kashyap, A. Khanna, E. Brauer, L. Morrow, Mohamed O. Seisa, D. Schroeder, D. Diedrich, Ashley A. Montgomery, P. M. Franco, Uchenna R. Ofoma, D. Kaufman, Ayan Sen, C. Callahan, Chakradhar Venkata, G. Demiralp, R. Tedja, Sarah Lee, M. Geube, Santhi I. Kumar, P. Morris, V. Bansal, S. Surani   +22 more
semanticscholar   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Perbandingan Efek Pemberian Cairan Kristaloid Sebelum Tindakan Anestesi Spinal (Preload) dan Sesaat Setelah Anestesi Spinal (Coload) terhadap Kejadian Hipotensi Maternal pada Seksio Sesarea

Jurnal Anestesi Perioperatif, 2016
Prophylactic fluid as a preload before spinal anesthesia has been a routine procedure to prevent maternal hypotension during cesarean delivery. Unlike colloid, timing of infusion of crystalloid may be important because it has short linger time in the ...
Zaki Fikran, Doddy Tavianto, Tinni T. Maskoen   +2 more
doaj   +1 more source

Nonlinear and conventional biosignal analyses applied to tilt table test for evaluating autonomic nervous system and autoregulation [PDF]

, 2013
Copyright © Tseng et al.; Licensee Bentham Open. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted, non ...
Castiglioni P, Chun-Yuan Chang, Cleophas TJM, Greenhalgh T, Gupta J, Jiann-Shing Shieh, Li Tseng, Lu CW, Maysam F. Abbod, Reinhard M, Reinhard M, Sornmo L, Sung-Chun Tang, Tang S C, Thayer J F, Thayer J F, Yi-Ching Lin   +16 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source