Results 111 to 120 of about 308,666 (390)

Predicting Blood Pressure Response to Fluid Bolus Therapy Using Attention-Based Neural Networks for Clinical Interpretability [PDF]

arXiv, 2018
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurrent neural network (RNN) algorithms
arxiv  

Period-dependent Associations between Hypotension during and for Four Days after Noncardiac Surgery and a Composite of Myocardial Infarction and Death: A Substudy of the POISE-2 Trial

Anesthesiology, 2017
Background: The relative contributions of intraoperative and postoperative hypotension to perioperative morbidity remain unclear. We determined the association between hypotension and a composite of 30-day myocardial infarction and death over three ...
D. Sessler, C. Meyhoff, N. Zimmerman, G. Mao, K. Leslie, S. Vásquez, P. Balaji, J. Álvarez-García, A. Cavalcanti, J. Parlow, P. Rahate, M. Seeberger, B. Gossetti, S. Walker, R. Premchand, R. M. Dahl, E. Duceppe, R. Rodseth, F. Botto, P. Devereaux   +19 more
semanticscholar   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Trajectories in New York Heart Association functional class in heart failure across the ejection fraction spectrum: data from the Swedish Heart Failure Registry

European Journal of Heart Failure, Volume 24, Issue 11, Page 2093-2104, November 2022., 2022
Stable New York Heart Association (NYHA) class over time was much more frequent than an improvement or a worsening. Follow‐up NYHA class assessment, but not change in NYHA class over time, was independently associated with better prognosis. CI, confidence interval; HR, hazard ratio.
Felix Lindberg, Lars H. Lund, Lina Benson, Ulf Dahlström, Patric Karlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese   +7 more
wiley   +1 more source

Multivariate Time-series Similarity Assessment via Unsupervised Representation Learning and Stratified Locality Sensitive Hashing: Application to Early Acute Hypotensive Episode Detection [PDF]

arXiv, 2018
Timely prediction of clinically critical events in Intensive Care Unit (ICU) is important for improving care and survival rate. Most of the existing approaches are based on the application of various classification methods on explicitly extracted statistical features from vital signals. In this work, we propose to eliminate the high cost of engineering
arxiv  

Prediction of hypotension events with physiologic vital sign signatures in the intensive care unit

Critical Care, 2020
Background Even brief hypotension is associated with increased morbidity and mortality. We developed a machine learning model to predict the initial hypotension event among intensive care unit (ICU) patients and designed an alert system for bedside ...
Joo Heung Yoon, V. Jeanselme, A. Dubrawski, M. Hravnak, M. Pinsky, G. Clermont   +5 more
semanticscholar   +1 more source

Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy

British Journal of Clinical Pharmacology, EarlyView.
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan, Katherine Z. Isoardi, Darren M. Roberts, Ong Sook Har   +3 more
wiley   +1 more source

Post-induction hypotension and early intraoperative hypotension associated with general anaesthesia

British Journal of Anaesthesia, 2017
Background We hypothesized that different phases of intraoperative hypotension should be differentiated because of different underlying causative mechanisms. We defined post-induction hypotension (PIH; i.e. arterial hypotension occurring during the first
S. Südfeld, S. Brechnitz, J. Y. Wagner, P. Reese, H. Pinnschmidt, D. Reuter, B. Saugel   +6 more
semanticscholar   +1 more source

Forecasting adverse surgical events using self-supervised transfer learning for physiological signals [PDF]

arXiv, 2020
Hundreds of millions of surgical procedures take place annually across the world, which generate a prevalent type of electronic health record (EHR) data comprising time series physiological signals. Here, we present a transferable embedding method (i.e., a method to transform time series signals into input features for predictive machine learning ...
arxiv  

Mechanisms, Clinical Implications, and Treatment of Intradialytic Hypotension.

American Society of Nephrology. Clinical Journal, 2018
Individuals with ESKD requiring maintenance hemodialysis face a unique hemodynamic challenge, typically on a thrice-weekly basis. In an effort to achieve some degree of euvolemia, ultrafiltration goals often involve removal of the equivalent of an entire
Patrick B Reeves, Finnian R. Mc Causland
semanticscholar   +1 more source