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Hypothalamic aging and hormones

2021
It is the heterogeneous changes of hypothalamic functions that determine the chronological sequence of aging in mammals. Recently, it was hypothesized by Cai the decrease in slow-wave sleep (SWS) resulting from skin aging as responsible for the degeneration of hypothalamic suprachiasmatic nucleus (SCN).
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Hypothalamic hormone-producing tumors

2021
The hypothalamus is functional neuroendocrine tissue that is responsible for the synthesis and secretion of peptide hormones that regulate the pituitary and other endocrine functions. Endocrine tumors of the hypothalamus are rare but they provide a model for tumors that have both structural and functional effects.
Sylvia L, Asa, Shereen, Ezzat
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Degradation of hypothalamic hormones

Naunyn-Schmiedebergs Archives of Pharmacology, 1977
The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed ...
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Hypothalamic effects of thyroid hormone

Molecular and Cellular Endocrinology, 2017
Thyroid hormone (TH) is a key driver of metabolism in mammals. Plasma concentrations of TH are kept within a narrow range by negative feedback regulation in the hypothalamus-pituitary-thyroid (HPT) axis. Plasma TH concentrations are an important determinant of metabolic processes in liver and brown adipose tissue (BAT). In addition to endocrine effects
Zhang, Zhi   +4 more
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Hypothalamic Hormones: Clinical Aspects

Pathology - Research and Practice, 1988
Clinical aspects of TRH, GHRH, Somatostatin (SS) and CRH as well as an effect of glucocorticoid on GH secretion are reported.
K, Kamijo, A, Yachi
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HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY

Clinical Endocrinology, 1975
SUMMARYThe growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in eleven patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and three showed no response.
A, Gomez-Pan   +7 more
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Growth hormone receptors in hypothalamic and extra-hypothalamic tissues

Journal of Molecular Endocrinology, 1990
ABSTRACT Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for 125I-labelled GH.
R A, Fraser, D, Attardo, S, Harvey
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Hypothalamic Hypophysiotropic Hormones

1975
A large body of experimental evidence supports the key role played by hypothalamic neurosecretory cells in coordinating the activities of the central nervous and endocrine systems. The nonapeptides vasopressin and oxytocin, synthesized in nerve cell bodies of the supraoptic and paraventricular nuclei, travel by axoplasmic flow within tracts terminating
Wylie Vale, Catherine Rivier
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The hypothalamic hormones

2015
Chapters 2 and 3 surveyed the hormones of the endocrine and pituitary glands. This chapter outlines the functions of the hypothalamus, and the hypothalamic neurosecretory cells and examines the role of the hypothalamus in controlling the release of pituitary hormones.
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