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Ethanol-induced Hypothermia in the Rat
Pharmacology, 1980Ethanol (0.5-3.2g x kg-1 i.p.) caused a dose-dependent fall in body temperature in rats. A dose of 1.5g x kg-1 i.p. led to a fall of 1.6 +/- 0.20 degrees C over 60 min at an environmental temperature of 18 +/- 1 degrees C. There was no evidence of acute tolerance when the hypothermic response was elicited by the same dose of ethanol (0.7--20.0g x kg-1 ...
R.R.J. Chaffee +3 more
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On the mechanism(s) of morphine-induced hypothermia
Journal of Psychopharmacology, 1994The effects of morphine on core body temperature of mice in the presence or absence of catecholamine receptor antagonists were examined. Administration of different doses of morphine (20, 30 and 40 mg/kg) to mice caused a hypothermic effect. Pre-treatment of animals with the opioid receptor antagonist naloxone (1, 1.5 and 3 mg/kg), the D-2 receptor ...
M R Heidari +3 more
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Phenitrone and marihuana induced hypothermia
Experientia, 1971Le phenitrone, souvent considere comme antagoniste specifique de la marihuana, n'a non seulement pas empeche la baisse de temperature corporelle cause par la tetrahydrocannabinol (THC), mais potentialise l'effet hypothermique de cette derniere. Il est possible que cette potentialisation est par suite du deplacement de la THC localisee dans les ...
C. Campbell, P. Lomax
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Cholecystokinin-induced hypothermia in the rat
Experientia, 1981Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.
R. Hirota, S. Itoh, G. Katsuura
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Naltrexone-induced hypothermia in the rat
European Journal of Pharmacology, 1976Naltrexone, in relatively high doses, has been reported to cause a fall in body temperature in human ex-heroin addicts who had been abstinent for at least 6 weeks. The underlying mechanism of this hypothermic effect has been investigated in rats. The first consideration was that the temperature change was a reflection of delayed withdrawal but rats ...
Sorensen Stephen M +3 more
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Induced Hypothermia is Not "Artificial Hibernation"
JAMA: The Journal of the American Medical Association, 1966The bleakness and chill of autumn evenings forewarns of the coming hostile winter season. Instinctively, a vast segment of the animal kingdom, unable to migrate to a more optimum biologic climate, prepares itself for survival. Through a variety of incredible methods, learned by each surviving species during millenniums of wintering experience, they ...
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Cholecystokinin and morphine-induced hypothermia
European Neuropsychopharmacology, 1999The effects of cholecystokinin-8 sulfate (CCK-8), cholecystokinin-8 unsulfate (CCK-8U), cholecystokinin-4 (CCK-4), caerulein and morphine on mice core body temperature have been studied in the present work. Subcutaneous injection of different doses of caerulein (0.05, 0.1 and 0.5 mg/kg), CCK-8 (0.05, 0.1 and 0.25 mg/kg) and morphine (10, 20 and 30 mg ...
Neda Ravandeh +2 more
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Stress and ethanol-induced hypothermia
Physiology & Behavior, 1987Three experiments examined the effects of three stressors on the hypothermic response to IP injection of ethanol in rats. Although all three stressors elicited hyperthermia in the absence of ethanol, only electric footshock reduced ethanol hypothermia. Handling/rectal-probing and bright, flashing light enhanced ethanol hypothermia.
Christopher L. Cunningham +1 more
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