Results 51 to 60 of about 77,030 (217)

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Hypothermia amongst neonatal admissions in Kenya: a retrospective cohort study assessing prevalence, trends, associated factors, and its relationship with all-cause neonatal mortality

Frontiers in Pediatrics
BackgroundReports on hypothermia from high-burden countries like Kenya amongst sick newborns often include few centers or relatively small sample sizes.ObjectivesThis study endeavored to describe: (i) the burden of hypothermia on admission across 21 ...
John Wainaina, Morris Ogero, Livingstone Mumelo, Kefa Wairoto, George Mbevi, Timothy Tuti, Paul Mwaniki, Grace Irimu, Grace Irimu, Mike English, Mike English, Jalemba Aluvaala, Jalemba Aluvaala, The Clinical Information Network Author Group, Dolphine Mochache, Juma Vitalis, Nyumbile Bonface, Christine Manyasi, Caren Emadau, Charles Nzioki, Wagura Mwangi, Magdalene Kuria, Esther Njiru, Penina Mwangi, Rachel Inginia, Emma Namulala, Grace Ochieng, Lydia Thuranira, Felistus Makokha, Josephine Ojigo, Beth Maina, Bernadette Lusweti, Amilia Ngoda, Dolphine Mochache, Jane Mbungu, Joan Baswetty, Josephine Aritho, Beatrice Njambi, Zainab Kioni, Lucy Kinyua, Alice Oguda, Loise N. Mwangi, Nancy Mburu, Celestine Muteshi, Salome Okisa Muyale, Faith Mueni, Rosemary Mututa, Joyce Oketch, Orina Nyakina, Faith Njeru, Margaret Wanjiku Mwaura, Seline Kulubi, Susan Wanjala, Pauline Njeru, John Ollongo, Samuel Soita, Mary Nguri, Margaret Waweru, Otieno George Obop, Jeska Kuya, Esther Muthiani, Esther Mwangi, Joseph Ng’ang’a, Benjamin Tanui, Alfred Wanjau, Judith Onsongo, Peter Muigai, Arnest Namayi   +67 more
doaj   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam, Yong Kwon Chae, Seoung‐Jin Hong, Younggen Lee, Dongwook Yang, Byunggi Kim, Sang Wook Kang, Young‐Jin Kim   +7 more
wiley   +1 more source

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco, Aaron Williams, Claudia Soler‐Alfonso, Emily Waskow, Elizabeth Mizerik, Fernando Scaglia, Chaya N. Murali   +6 more
wiley   +1 more source

Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy

Общая реаниматология
Prevention of brain injury during carotid endarterectomy (CEA) remains a significant challenge. Moderate controlled systemic hypothermia may serve as a potential neuroprotective measure during these procedures.Aim of the study.
Alexey A. Syrovatsky, Ionas S. Simutis, Alexey V. Svetlikov, Konstantin M. Lebedinsky, Alexey N. Shcheglov, Vyacheslav A. Ratnikov, Daria E. Reznichek, Evgenia V. Khaldina   +7 more
doaj   +1 more source

Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest.

PLoS ONE, 2019
Therapeutic hypothermia initiated during cardiopulmonary resuscitation (CPR) in pre-clinical studies appears to be highly protective against sudden cardiac arrest injury.
Jing Li, Xiangdong Zhu, Huashan Wang, Chunpei Lee, Sy-Jou Chen, Yuanyu Qian, Mei Han, Ryan Bunney, David G Beiser, Terry L Vanden Hoek   +9 more
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

The lower deciduous dentition of protodidelphids (Mammalia, Marsupialia) from the Itaboraí Basin (lower Eocene), Brazil, and the validity of “Riolestes capricornicus” (Goin et al., 2009)

The Anatomical Record, EarlyView.
Abstract The Itaboraí Basin, Southeastern Brazil, preserved one of the most diverse mammalian faunas from the Paleogene, with Metatheria comprising more than 60% of its diversity. Among identified metatherian clades, it has been argued that Paucituberculata is represented by “Riolestes capricornicus”.
Leonardo M. Carneiro, Hugo Bampi, João P. P. Araújo, Marina B. Soares, Gustavo R. Oliveira   +4 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source