Results 81 to 90 of about 241,895 (388)
CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation
Advanced Science, EarlyView.Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao +18 more
wiley +1 more source
Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]
, 2001 Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Boer, Sietse F. de, +5 more
core +1 more source
Circulation, 2019 Background: Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in ...
G. Fuernau +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.A gravity‐independent filamented light (G‐FLight) projection method is presented for rapid biofabrication of anisotropic tissues, demonstrated with muscle constructs as a target application. Specialized photocrosslinkable resins enable refrigeration or cryopreservation with encapsulated cells.
Michael Winkelbauer +13 more
wiley +1 more source
Osborn Waves: History and Significance [PDF]
, 2004 The Osborn wave is a deflection with a dome or hump configuration occurring at the R-ST junction (J point) on the ECG (Fig. 1). In the historical view, different names have been used for this wave in the medical literature, such as “camel-hump sign ...
Atarashi, Hirotsugu +6 more
core +2 more sources
Korean Journal of Anesthesiology, 2010 Pioneer works on therapeutic hypothermia (TH) half a century ago already showed promising results but clinical application was limited by a lack of understanding of the underlying pathophysiology, lack of reliable method for temperature control and lack of intensive care facilities to deal with possible complications.
openaire +3 more sources
Therapeutic Hypothermia and Temperature Management, 2019 Three decades of animal studies have reproducibly shown that hypothermia is profoundly cerebroprotective during or after a central nervous system (CNS) insult.
Travis C. Jackson, P. Kochanek
semanticscholar +1 more source
Out of the Crystalline Comfort Zone: Sampling the Initial Oxide Formation At Cu(111)
Advanced Science, EarlyView.By combining replica exchange molecular dynamics with fast and efficient machine‐learned interatomic potentials, this computational study predicts the complex surface reconstructions accompanying the early Cu(111) surface oxidation. The unprecedentedly exhaustive sampling results in a high‐quality surface phase diagram that not only recovers known ...
Felix Riccius +3 more
wiley +1 more source
Emerging Nanozyme Strategies for Precision Breast Cancer Treatment
Advanced Science, EarlyView.Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang +6 more
wiley +1 more source
Adding ROS Scavengers to Cold K\u3csup\u3e+\u3c/sup\u3e Cardioplegia Reduces Superoxide Emission During 2 h Global Cold Cardiac Ischemia [PDF]
, 2012 We reported that the combination of reactive oxygen species (ROS) quenchers Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), catalase, and glutathione (MCG) given before 2 hours cold ischemia better protected cardiac mitochondria against cold ...
Aldakkak, Mohammed +4 more
core +1 more source