Results 51 to 60 of about 33,360 (154)

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

EBioMedicine, 2016
Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau becomes hyperphosphorylated in injury-resistant, hypothermic brains.
Nina M. Rzechorzek, Peter Connick, Matthew R. Livesey, Shyamanga Borooah, Rickie Patani, Karen Burr, David Story, David J.A. Wyllie, Giles E. Hardingham, Siddharthan Chandran   +9 more
doaj   +1 more source

Excitation-contraction coupling in hypothermic ischemic myocardium

, 1981
The excitation-contraction coupling system of the global ischemic hypothermic myocardium was studied by evaluating the functional integrity of the isolated sarcoplasmic reticulum (SR) and myofibrils and determining glycogen decay 30 and 60 min after the
S. M. Krause, A. D. Robbins, L. J. Greenfield, M. L. Hess   +3 more
core   +1 more source

Preservation of myocyte contractile function after hypothermic, hyperkalemic cardioplegic arrest with 2,3-butanedione monoxime [PDF]

, 1996
One proposed contributory mechanism for depressed ventricular performance after hypothermic, hyperkalemic cardioplegic arrest is a reduction in myocyte contractile function caused by alterations in intracellular calcium homeostasis.
Roy, Raymond C., Dorman, B.Hugh, Spinale, Francis G., Hinton, Robert B., Cavallo, Martyn J.   +4 more
core   +1 more source

Current conduct of deep hypothermic circulatory arrest in China.

, 2013
IntroductionDeep hypothermic circulatory arrest for adult aortic arch repair is still associated with significant mortality and morbidity. Furthermore, there is still significant variation in the conduct of this complex perioperative technique.
Choi, J, Yue, Y, Augoustides, JGT, Silvay, G, Patel, P, Ghadimi, K   +5 more
core   +1 more source

Analysis of Perioperative Factors for Neurological Dysfunction in Patients with Thoracic Aortic Surgery

Archives of Clinical and Experimental Surgery, 2013
Objectives: Surgical procedures for various aortic arch pathologies still result in high mortality and morbidity. Success in these aortic procedures is directly related to cerebral protection techniques during circulatory arrest. Herein, we analyzed risk
Manabu Shiraishi, Shin-ichi Ohki, Arata Muraoka, Kei Aizawa, Yasuhito Sakano, Yuichiro Kaminishi, Yoshio Misawa   +6 more
doaj   +1 more source

Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

Journal of Inflammation, 2020
Background Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes.
Ludmila Khailova, Justin Robison, James Jaggers, Richard Ing, Scott Lawson, Amy Treece, Danielle Soranno, Suzanne Osorio Lujan, Jesse A. Davidson   +8 more
doaj   +1 more source

Role of hypothermic machine perfusion in liver transplantation.

, 2015
Machine liver perfusion has significantly evolved during the last ten years to optimize extended criteria liver grafts and to address the worldwide organ shortage. This review gives an overview on available ex vivo and in vivo data on hypothermic machine
Schlegel A, Dutkowski P
core   +1 more source

Differential Effectiveness of Hypothermic Targeted Temperature Management According to the Severity of Post-Cardiac Arrest Syndrome

, 2021
International guidelines recommend targeted temperature management (TTM) to improve the neurological outcomes in adult patients with post-cardiac arrest syndrome (PCAS). However, it still remains unclear if the lower temperature setting (hypothermic TTM)
Mitsuaki Nishikimi, Nobuaki Shime, Michihito Kyo, Kazuya Kikutani, Shinichiro Ohshimo, Tatsutoshi Shimatani   +5 more
core   +1 more source

Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model

Brazilian Journal of Veterinary Pathology, 2017
The aim of the present study was to investigate the effects of intraportal administration of hypothermic hydrogen-rich saline solution (HRSS) on hepatic ischemia/reperfusion (I/R) injury.
Hannaneh Golshahi, Abbas Tavasoly, Seyed Hossein Mardjanmehr, Khosrou M. Abdi, Mohammad Mehdi Dehghan, Saeed Farzad Mohajeri   +5 more
doaj   +1 more source

Global SUMOylation is a Molecular Mechanism Underlying Hypothermia-induced Ischemic Tolerance

Frontiers in Cellular Neuroscience, 2014
The molecular mechanisms underlying hypothermic neuroprotection have yet to be fully elucidated. Herein we demonstrate that global SUMOylation, a form of post-translational modification with the Small Ubiquitin-like MOdifer, participates in the ...
Yang-ja eLee, Yongshan eMou, Dace eKlimanis, Joshua D Bernstock, John M. Hallenbeck   +4 more
doaj   +1 more source